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. 1995 Sep;63(9):3715–3717. doi: 10.1128/iai.63.9.3715-3717.1995

Tumor necrosis factor alpha acts as an autocrine second signal with gamma interferon to induce nitric oxide in group B streptococcus-treated macrophages.

K J Goodrum 1, J Dierksheide 1, B J Yoder 1
PMCID: PMC173516  PMID: 7642312

Abstract

Nitric oxide production by mouse macrophages treated with group B streptococci and gamma interferon was inhibited by cytochalasin B or by antibody neutralization of macrophage-derived tumor necrosis factor alpha. Phagocytosis-induced tumor necrosis factor alpha is responsible for group B streptococcus-induced nitric oxide production in interferon-treated macrophages.

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Selected References

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