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. 1995 Sep;63(9):3718–3721. doi: 10.1128/iai.63.9.3718-3721.1995

Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae.

J V Solnick 1, C Josenhans 1, S Suerbaum 1, L S Tompkins 1, A Labigne 1
PMCID: PMC173517  PMID: 7642313

Abstract

Helicobacter mustelae infects the ferret stomach and provides an opportunity to study pathogenic determinants of a Helicobacter species in its natural host. We constructed an isogenic urease-negative mutant of H. mustelae which produced no detectable urease and showed a reduced acid tolerance. This mutant provides an opportunity to further evaluate the role of urease in the pathogenesis of Helicobacter infection.

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Selected References

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