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. 1995 Oct;63(10):4178–4180. doi: 10.1128/iai.63.10.4178-4180.1995

Production of tumor necrosis factor alpha, interleukin-1 alpha, and interleukin-6 during murine coccidioidomycosis.

R A Cox 1, D M Magee 1
PMCID: PMC173589  PMID: 7558338

Abstract

The proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha), interleukin-1 alpha (IL-1 alpha), and interleukin-6 (IL-6) were induced in mice infected with Coccidioides immitis. Analyses of the cytokine profiles of two inbred mouse strains which differ in their susceptibility to pulmonary challenge with C. immitis revealed higher levels of IL-6 in lungs from DBA/2 mice (resistant strain) than in those from BALB/c mice (susceptible strain) beginning at day 6 and continuing through day 15 postinfection. Spleen cells from both mouse strains secreted TNF-alpha, IL-1 alpha, and IL-6 in vitro in response to stimulation with killed spherules but differed in that spleen cells from the resistant strain produced increased levels of these cytokines earlier after pulmonary challenge and at increased levels throughout the course of the disease.

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Selected References

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  1. Ampel N. M., Bejarano G. C., Galgiani J. N. Killing of Coccidioides immitis by human peripheral blood mononuclear cells. Infect Immun. 1992 Oct;60(10):4200–4204. doi: 10.1128/iai.60.10.4200-4204.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ampel N. M. In vitro production of tumor necrosis factor-alpha by adherent human peripheral blood mononuclear cells incubated with killed coccidioidal arthroconidia and spherules. Cell Immunol. 1994 Jan;153(1):248–255. doi: 10.1006/cimm.1994.1022. [DOI] [PubMed] [Google Scholar]
  3. Bayer A. S., Yoshikawa T. T., Galpin J. E., Guze L. B. Unusual syndromes of coccidioidomycosis: diagnostic and therapeutic considerations; a report of 10 cases and review of the English literature. Medicine (Baltimore) 1976 Mar;55(2):131–152. doi: 10.1097/00005792-197603000-00003. [DOI] [PubMed] [Google Scholar]
  4. Beaman L. Effects of recombinant gamma interferon and tumor necrosis factor on in vitro interactions of human mononuclear phagocytes with Coccidioides immitis. Infect Immun. 1991 Nov;59(11):4227–4229. doi: 10.1128/iai.59.11.4227-4229.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Beaman L. Fungicidal activation of murine macrophages by recombinant gamma interferon. Infect Immun. 1987 Dec;55(12):2951–2955. doi: 10.1128/iai.55.12.2951-2955.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Beutler B., Cerami A. Cachectin (tumor necrosis factor): a macrophage hormone governing cellular metabolism and inflammatory response. Endocr Rev. 1988 Feb;9(1):57–66. doi: 10.1210/edrv-9-1-57. [DOI] [PubMed] [Google Scholar]
  7. Cerami A. Inflammatory cytokines. Clin Immunol Immunopathol. 1992 Jan;62(1 Pt 2):S3–10. doi: 10.1016/0090-1229(92)90035-m. [DOI] [PubMed] [Google Scholar]
  8. Cox R. A., Kennell W., Boncyk L., Murphy J. W. Induction and expression of cell-mediated immune responses in inbred mice infected with Coccidioides immitis. Infect Immun. 1988 Jan;56(1):13–17. doi: 10.1128/iai.56.1.13-17.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Dooley D. P., Cox R. A., Hestilow K. L., Dolan M. J., Magee D. M. Cytokine induction in human coccidioidomycosis. Infect Immun. 1994 Sep;62(9):3980–3983. doi: 10.1128/iai.62.9.3980-3983.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Drutz D. J., Catanzaro A. Coccidioidomycosis. Part II. Am Rev Respir Dis. 1978 Apr;117(4):727–771. doi: 10.1164/arrd.1978.117.4.727. [DOI] [PubMed] [Google Scholar]
  11. Drutz D. J., Huppert M. Coccidioidomycosis: factors affecting the host-parasite interaction. J Infect Dis. 1983 Mar;147(3):372–390. doi: 10.1093/infdis/147.3.372. [DOI] [PubMed] [Google Scholar]
  12. Kirkland T. N., Fierer J. Genetic control of resistance to Coccidioides immitis: a single gene that is expressed in spleen cells determines resistance. J Immunol. 1985 Jul;135(1):548–552. [PubMed] [Google Scholar]
  13. Lopez A. M., Williams P. L., Ampel N. M. Acute pulmonary coccidioidomycosis mimicking bacterial pneumonia and septic shock: a report of two cases. Am J Med. 1993 Aug;95(2):236–239. doi: 10.1016/0002-9343(93)90267-s. [DOI] [PubMed] [Google Scholar]
  14. Molloy R. G., Mannick J. A., Rodrick M. L. Cytokines, sepsis and immunomodulation. Br J Surg. 1993 Mar;80(3):289–297. doi: 10.1002/bjs.1800800308. [DOI] [PubMed] [Google Scholar]
  15. Montgomery R. A., Dallman M. J. Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J Immunol. 1991 Jul 15;147(2):554–560. [PubMed] [Google Scholar]
  16. Murphy E., Hieny S., Sher A., O'Garra A. Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice. J Immunol Methods. 1993 Jun 18;162(2):211–223. doi: 10.1016/0022-1759(93)90386-l. [DOI] [PubMed] [Google Scholar]
  17. O'Garra A., Vieira P. Polymerase chain reaction for detection of cytokine gene expression. Curr Opin Immunol. 1992 Apr;4(2):211–215. doi: 10.1016/0952-7915(92)90016-8. [DOI] [PubMed] [Google Scholar]
  18. Petkus A. F., Baum L. L. Natural killer cell inhibition of young spherules and endospores of Coccidioides immitis. J Immunol. 1987 Nov 1;139(9):3107–3111. [PubMed] [Google Scholar]
  19. Slagle D. C., Cox R. A., Kuruganti U. Induction of tumor necrosis factor alpha by spherules of Coccidioides immitis. Infect Immun. 1989 Jul;57(7):1916–1921. doi: 10.1128/iai.57.7.1916-1921.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]

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