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. 1999 Jan;66(1):57–63. doi: 10.1136/jnnp.66.1.57

Effects of stimulant medication on the lateralisation of line bisection judgements of children with attention deficit hyperactivity disorder

D Sheppard 1, J Bradshaw 1, J Mattingley 1, P Lee 1
PMCID: PMC1736185  PMID: 9886453

Abstract

OBJECTIVES—Deficits in the maintenance of attention may underlie problems in attention deficit hyperactivity disorder (ADHD). Children with ADHD also show asymmetric attention deficits in traditional lateralisation and visuospatial orienting tasks, suggesting right hemispheric (and left hemispace) attentional disturbance. This study aimed to examine the lateralisation of selective attention in ADHD; specifically, the effect of a moving, random dot background, and stimulant medication in the line bisection task.
METHODS—The performance of children with ADHD, on and off methylphenidate, was examined using a computerised horizontal line bisection task with moving and blank backgrounds. Twenty children with a DSM-IV diagnosis of ADHD participated with 20 controls, individually matched for age, sex, grade at school, and IQ. Twelve of the 20children with ADHD were on stimulant medication at the time of testing. Horizontal lines of varying length were presented in the centre of a computer screen, with either a blank background, or a moving, random dot field. The random dots moved either leftward or rightward across the screen at either 40 mm/s or 80 mm/s.
RESULTS—The children with ADHD off medication bisected lines significantly further to the right compared with controls, who showed a small leftward error. Methylphenidate normalised the performance of the children with ADHD for the task with the moving dots.
CONCLUSIONS—These results support previous evidence for a right hemispheric hypoarousal theory of attentional dysfunction, and are consistent with the emerging picture of a lateralised dysfunction of frontostriatal circuitry in ADHD.



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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barkley R. A. Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull. 1997 Jan;121(1):65–94. doi: 10.1037/0033-2909.121.1.65. [DOI] [PubMed] [Google Scholar]
  2. Bradshaw J. L., Bradshaw J. A., Nathan G., Nettleton N. C., Wilson L. E. Leftwards error in bisecting the gap between two points: stimulus quality and hand effects. Neuropsychologia. 1986;24(6):849–855. doi: 10.1016/0028-3932(86)90084-9. [DOI] [PubMed] [Google Scholar]
  3. Bradshaw J. L., Bradshaw J. A., Nettleton N. C. Direction and location of movement in kinesthetic judgements of extent. Neuropsychologia. 1989;27(9):1139–1151. doi: 10.1016/0028-3932(89)90097-3. [DOI] [PubMed] [Google Scholar]
  4. Bradshaw J. L., Nettleton N. C., Nathan G., Wilson L. Tactual-kinesthetic matching of horizontal extents by the long-term blind: absence or reversal of normal left-side underestimation. Neuropsychologia. 1986;24(2):261–264. doi: 10.1016/0028-3932(86)90058-8. [DOI] [PubMed] [Google Scholar]
  5. Butter C. M., Mark V. W., Heilman K. M. An experimental analysis of factors underlying neglect in line bisection. J Neurol Neurosurg Psychiatry. 1988 Dec;51(12):1581–1583. doi: 10.1136/jnnp.51.12.1581. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Carter C. S., Krener P., Chaderjian M., Northcutt C., Wolfe V. Asymmetrical visual-spatial attentional performance in ADHD: evidence for a right hemispheric deficit. Biol Psychiatry. 1995 Jun 1;37(11):789–797. doi: 10.1016/0006-3223(94)00217-Q. [DOI] [PubMed] [Google Scholar]
  7. Castellanos F. X., Giedd J. N., Marsh W. L., Hamburger S. D., Vaituzis A. C., Dickstein D. P., Sarfatti S. E., Vauss Y. C., Snell J. W., Lange N. Quantitative brain magnetic resonance imaging in attention-deficit hyperactivity disorder. Arch Gen Psychiatry. 1996 Jul;53(7):607–616. doi: 10.1001/archpsyc.1996.01830070053009. [DOI] [PubMed] [Google Scholar]
  8. Di Pellegrino G., De Renzi E. An experimental investigation on the nature of extinction. Neuropsychologia. 1995 Feb;33(2):153–170. doi: 10.1016/0028-3932(94)00111-2. [DOI] [PubMed] [Google Scholar]
  9. Driver J., Baylis G. C., Rafal R. D. Preserved figure-ground segregation and symmetry perception in visual neglect. Nature. 1992 Nov 5;360(6399):73–75. doi: 10.1038/360073a0. [DOI] [PubMed] [Google Scholar]
  10. Epstein J. N., Conners C. K., Erhardt D., March J. S., Swanson J. M. Asymmetrical hemispheric control of visual-spatial attention in adults with attention deficit hyperactivity disorder. Neuropsychology. 1997 Oct;11(4):467–473. doi: 10.1037/0894-4105.11.4.467. [DOI] [PubMed] [Google Scholar]
  11. Halligan P. W., Marshall J. C. Figural modulation of visuo-spatial neglect: a case study. Neuropsychologia. 1991;29(7):619–628. doi: 10.1016/0028-3932(91)90097-r. [DOI] [PubMed] [Google Scholar]
  12. Heilman K. M., Van Den Abell T. Right hemispheric dominance for mediating cerebral activation. Neuropsychologia. 1979;17(3-4):315–321. doi: 10.1016/0028-3932(79)90077-0. [DOI] [PubMed] [Google Scholar]
  13. Heilman K. M., Voeller K. K., Nadeau S. E. A possible pathophysiologic substrate of attention deficit hyperactivity disorder. J Child Neurol. 1991;6 (Suppl):S76–S81. doi: 10.1177/0883073891006001s09. [DOI] [PubMed] [Google Scholar]
  14. Hynd G. W., Hern K. L., Novey E. S., Eliopulos D., Marshall R., Gonzalez J. J., Voeller K. K. Attention deficit-hyperactivity disorder and asymmetry of the caudate nucleus. J Child Neurol. 1993 Oct;8(4):339–347. doi: 10.1177/088307389300800409. [DOI] [PubMed] [Google Scholar]
  15. Lou H. C., Henriksen L., Bruhn P., Børner H., Nielsen J. B. Striatal dysfunction in attention deficit and hyperkinetic disorder. Arch Neurol. 1989 Jan;46(1):48–52. doi: 10.1001/archneur.1989.00520370050018. [DOI] [PubMed] [Google Scholar]
  16. Mataró M., Garcia-Sánchez C., Junqué C., Estévez-González A., Pujol J. Magnetic resonance imaging measurement of the caudate nucleus in adolescents with attention-deficit hyperactivity disorder and its relationship with neuropsychological and behavioral measures. Arch Neurol. 1997 Aug;54(8):963–968. doi: 10.1001/archneur.1997.00550200027006. [DOI] [PubMed] [Google Scholar]
  17. Mattingley J. B., Bradshaw J. L., Bradshaw J. A. Horizontal visual motion modulates focal attention in left unilateral spatial neglect. J Neurol Neurosurg Psychiatry. 1994 Oct;57(10):1228–1235. doi: 10.1136/jnnp.57.10.1228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Mendez M. F., Adams N. L., Lewandowski K. S. Neurobehavioral changes associated with caudate lesions. Neurology. 1989 Mar;39(3):349–354. doi: 10.1212/wnl.39.3.349. [DOI] [PubMed] [Google Scholar]
  19. Nigg J. T., Swanson J. M., Hinshaw S. P. Covert visual spatial attention in boys with attention deficit hyperactivity disorder: lateral effects, methylphenidate response and results for parents. Neuropsychologia. 1997 Feb;35(2):165–176. doi: 10.1016/s0028-3932(96)00070-x. [DOI] [PubMed] [Google Scholar]
  20. Pardo J. V., Fox P. T., Raichle M. E. Localization of a human system for sustained attention by positron emission tomography. Nature. 1991 Jan 3;349(6304):61–64. doi: 10.1038/349061a0. [DOI] [PubMed] [Google Scholar]
  21. Posner M. I., Walker J. A., Friedrich F. J., Rafal R. D. Effects of parietal injury on covert orienting of attention. J Neurosci. 1984 Jul;4(7):1863–1874. doi: 10.1523/JNEUROSCI.04-07-01863.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Robertson I. H., Mattingley J. B., Rorden C., Driver J. Phasic alerting of neglect patients overcomes their spatial deficit in visual awareness. Nature. 1998 Sep 10;395(6698):169–172. doi: 10.1038/25993. [DOI] [PubMed] [Google Scholar]
  23. Robertson I. H., Tegnér R., Tham K., Lo A., Nimmo-Smith I. Sustained attention training for unilateral neglect: theoretical and rehabilitation implications. J Clin Exp Neuropsychol. 1995 May;17(3):416–430. doi: 10.1080/01688639508405133. [DOI] [PubMed] [Google Scholar]
  24. Rueckert L., Grafman J. Sustained attention deficits in patients with right frontal lesions. Neuropsychologia. 1996 Oct;34(10):953–963. doi: 10.1016/0028-3932(96)00016-4. [DOI] [PubMed] [Google Scholar]
  25. Schenkenberg T., Bradford D. C., Ajax E. T. Line bisection and unilateral visual neglect in patients with neurologic impairment. Neurology. 1980 May;30(5):509–517. doi: 10.1212/wnl.30.5.509. [DOI] [PubMed] [Google Scholar]
  26. Voeller K. K., Heilman K. M. Attention deficit disorder in children: a neglect syndrome? Neurology. 1988 May;38(5):806–808. doi: 10.1212/wnl.38.5.806. [DOI] [PubMed] [Google Scholar]
  27. Wilkins A. J., Shallice T., McCarthy R. Frontal lesions and sustained attention. Neuropsychologia. 1987;25(2):359–365. doi: 10.1016/0028-3932(87)90024-8. [DOI] [PubMed] [Google Scholar]
  28. Zametkin A. J., Nordahl T. E., Gross M., King A. C., Semple W. E., Rumsey J., Hamburger S., Cohen R. M. Cerebral glucose metabolism in adults with hyperactivity of childhood onset. N Engl J Med. 1990 Nov 15;323(20):1361–1366. doi: 10.1056/NEJM199011153232001. [DOI] [PubMed] [Google Scholar]

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