Abstract
To assess the clinical, topographical, and aetiological features of multiple cerebellar infarcts,18 patients (16.5% of patients with cerebellar infarction) were collected from a prospective acute stroke registry, using a standard investigation protocol including MRI and magnetic resonance angiography. Infarcts in the posterior inferior cerebellar artery (PICA)+superior cerebellar artery (SCA) territory were most common (9/18; 50%), followed by PICA+anterior inferior cerebellar artery (AICA)+SCA territory infarcts (6/18; 33%). One patient had bilateral AICA infarcts. No infarct involved the PICA+AICA combined territory. Other infarcts in the posterior circulation were present in half of the patients and the clinical presentation largely depended on them. Large artery disease was the main aetiology. Our findings emphasised the common occurrence of very small multiple cerebellar infarcts (<2 cm diameter).These very small multiple cerebellar infarcts may occur with (13 patients/18; 72%) or without (3/18; 22%) territorial cerebellar infarcts. Unlike previous series, they could not all be considered junctional infarcts (between two main cerebellar artery territories: 51/91), but also small territorial infarcts (40/91). It is suggested that these very small territorial infarcts may be endzone infarcts, due to the involvement of small distal arterial branches. It is possible that some very small territorial infarcts may be due to a microembolic process, but this hypothesis needs pathological confirmation.
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- Amarenco P., Hauw J. J. Anatomie des arteres cerebelleuses. Rev Neurol (Paris) 1989;145(4):267–276. [PubMed] [Google Scholar]
- Amarenco P., Hauw J. J. Cerebellar infarction in the territory of the superior cerebellar artery: a clinicopathologic study of 33 cases. Neurology. 1990 Sep;40(9):1383–1390. doi: 10.1212/wnl.40.9.1383. [DOI] [PubMed] [Google Scholar]
- Amarenco P., Kase C. S., Rosengart A., Pessin M. S., Bousser M. G., Caplan L. R. Very small (border zone) cerebellar infarcts. Distribution, causes, mechanisms and clinical features. Brain. 1993 Feb;116(Pt 1):161–186. doi: 10.1093/brain/116.1.161. [DOI] [PubMed] [Google Scholar]
- Amarenco P., Lévy C., Cohen A., Touboul P. J., Roullet E., Bousser M. G. Causes and mechanisms of territorial and nonterritorial cerebellar infarcts in 115 consecutive patients. Stroke. 1994 Jan;25(1):105–112. doi: 10.1161/01.str.25.1.105. [DOI] [PubMed] [Google Scholar]
- Amarenco P., Roullet E., Hommel M., Chaine P., Marteau R. Infarction in the territory of the medial branch of the posterior inferior cerebellar artery. J Neurol Neurosurg Psychiatry. 1990 Sep;53(9):731–735. doi: 10.1136/jnnp.53.9.731. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Amarenco P. The spectrum of cerebellar infarctions. Neurology. 1991 Jul;41(7):973–979. doi: 10.1212/wnl.41.7.973. [DOI] [PubMed] [Google Scholar]
- Barth A., Bogousslavsky J., Regli F. Infarcts in the territory of the lateral branch of the posterior inferior cerebellar artery. J Neurol Neurosurg Psychiatry. 1994 Sep;57(9):1073–1076. doi: 10.1136/jnnp.57.9.1073. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barth A., Bogousslavsky J., Regli F. The clinical and topographic spectrum of cerebellar infarcts: a clinical-magnetic resonance imaging correlation study. Ann Neurol. 1993 May;33(5):451–456. doi: 10.1002/ana.410330507. [DOI] [PubMed] [Google Scholar]
- Bogousslavsky J., Cachin C., Regli F., Despland P. A., Van Melle G., Kappenberger L. Cardiac sources of embolism and cerebral infarction--clinical consequences and vascular concomitants: the Lausanne Stroke Registry. Neurology. 1991 Jun;41(6):855–859. doi: 10.1212/wnl.41.6.855. [DOI] [PubMed] [Google Scholar]
- Bogousslavsky J., Regli F. Latéro-pulsion axiale isolée lors d'un infarctus cérébelleux flocculo-nodulaire. Rev Neurol (Paris) 1984;140(2):140–143. [PubMed] [Google Scholar]
- Bogousslavsky J., Regli F., Maeder P., Meuli R., Nader J. The etiology of posterior circulation infarcts: a prospective study using magnetic resonance imaging and magnetic resonance angiography. Neurology. 1993 Aug;43(8):1528–1533. doi: 10.1212/wnl.43.8.1528. [DOI] [PubMed] [Google Scholar]
- Bogousslavsky J., Van Melle G., Regli F. The Lausanne Stroke Registry: analysis of 1,000 consecutive patients with first stroke. Stroke. 1988 Sep;19(9):1083–1092. doi: 10.1161/01.str.19.9.1083. [DOI] [PubMed] [Google Scholar]
- Caplan L. R. "Top of the basilar" syndrome. Neurology. 1980 Jan;30(1):72–79. doi: 10.1212/wnl.30.1.72. [DOI] [PubMed] [Google Scholar]
- Caplan L. R., Amarenco P., Rosengart A., Lafranchise E. F., Teal P. A., Belkin M., DeWitt L. D., Pessin M. S. Embolism from vertebral artery origin occlusive disease. Neurology. 1992 Aug;42(8):1505–1512. doi: 10.1212/wnl.42.8.1505. [DOI] [PubMed] [Google Scholar]
- Kase C. S., Norrving B., Levine S. R., Babikian V. L., Chodosh E. H., Wolf P. A., Welch K. M. Cerebellar infarction. Clinical and anatomic observations in 66 cases. Stroke. 1993 Jan;24(1):76–83. doi: 10.1161/01.str.24.1.76. [DOI] [PubMed] [Google Scholar]
- Kase C. S., White J. L., Joslyn J. N., Williams J. P., Mohr J. P. Cerebellar infarction in the superior cerebellar artery distribution. Neurology. 1985 May;35(5):705–711. doi: 10.1212/wnl.35.5.705. [DOI] [PubMed] [Google Scholar]
- Marinković S., Kovacević M., Gibo H., Milisavljević M., Bumbasirević L. The anatomical basis for the cerebellar infarcts. Surg Neurol. 1995 Nov;44(5):450–461. doi: 10.1016/0090-3019(95)00195-6. [DOI] [PubMed] [Google Scholar]
- Röther J., Wentz K. U., Rautenberg W., Schwartz A., Hennerici M. Magnetic resonance angiography in vertebrobasilar ischemia. Stroke. 1993 Sep;24(9):1310–1315. doi: 10.1161/01.str.24.9.1310. [DOI] [PubMed] [Google Scholar]
- Savoiardo M., Bracchi M., Passerini A., Visciani A. The vascular territories in the cerebellum and brainstem: CT and MR study. AJNR Am J Neuroradiol. 1987 Mar-Apr;8(2):199–209. [PMC free article] [PubMed] [Google Scholar]
- Tatu L., Moulin T., Bogousslavsky J., Duvernoy H. Arterial territories of human brain: brainstem and cerebellum. Neurology. 1996 Nov;47(5):1125–1135. doi: 10.1212/wnl.47.5.1125. [DOI] [PubMed] [Google Scholar]
- Tohgi H., Takahashi S., Chiba K., Hirata Y. Cerebellar infarction. Clinical and neuroimaging analysis in 293 patients. The Tohoku Cerebellar Infarction Study Group. Stroke. 1993 Nov;24(11):1697–1701. doi: 10.1161/01.str.24.11.1697. [DOI] [PubMed] [Google Scholar]
- Trouillas P., Nighoghossian N., Philippon B. Nuclear hemodynamic vertebrobasilar insufficiency. A new approach with the xenon Xe 133 method. Arch Neurol. 1991 Sep;48(9):921–929. doi: 10.1001/archneur.1991.00530210047023. [DOI] [PubMed] [Google Scholar]