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. 1995 Nov;63(11):4543–4545. doi: 10.1128/iai.63.11.4543-4545.1995

Serum response of Escherichia coli strains causing dyspepsia and urinary tract infection: relation to alpha-hemolysin production and O type.

L Siegfried 1, M Kmetová 1, V Janigová 1, M Sasinka 1, V Takácová 1
PMCID: PMC173650  PMID: 7591101

Abstract

A total of 109 alpha-hemolytic and 104 nonhemolytic Escherichia coli isolates from children with dyspepsia and urinary tract infections were investigated for resistance to the bactericidal activity of human serum. A significantly higher proportion of serum resistance was found in alpha-hemolytic E. coli isolates than in nonhemolytic isolates (P < 0.01). An association between the titer of alpha-hemolysin produced and serum resistance was found.

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Selected References

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  1. Aguero M. E., de la Fuente G., Vivaldi E., Cabello F. ColV increases the virulence of Escherichia coli K1 strains in animal models of neonatal meningitis and urinary infection. Med Microbiol Immunol. 1989;178(4):211–216. doi: 10.1007/BF00202554. [DOI] [PubMed] [Google Scholar]
  2. Benge G. R. Bactericidal activity of human serum against strains of Klebsiella from different sources. J Med Microbiol. 1988 Sep;27(1):11–15. doi: 10.1099/00222615-27-1-11. [DOI] [PubMed] [Google Scholar]
  3. Caprioli A., Falbo V., Ruggeri F. M., Baldassarri L., Bisicchia R., Ippolito G., Romoli E., Donelli G. Cytotoxic necrotizing factor production by hemolytic strains of Escherichia coli causing extraintestinal infections. J Clin Microbiol. 1987 Jan;25(1):146–149. doi: 10.1128/jcm.25.1.146-149.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cavalieri S. J., Bohach G. A., Snyder I. S. Escherichia coli alpha-hemolysin: characteristics and probable role in pathogenicity. Microbiol Rev. 1984 Dec;48(4):326–343. doi: 10.1128/mr.48.4.326-343.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cross A. S., Kim K. S., Wright D. C., Sadoff J. C., Gemski P. Role of lipopolysaccharide and capsule in the serum resistance of bacteremic strains of Escherichia coli. J Infect Dis. 1986 Sep;154(3):497–503. doi: 10.1093/infdis/154.3.497. [DOI] [PubMed] [Google Scholar]
  6. De Man P., Jodal U., Van Kooten C., Svanborg C. Bacterial adherence as a virulence factor in urinary tract infection. APMIS. 1990 Dec;98(12):1053–1060. doi: 10.1111/j.1699-0463.1990.tb05034.x. [DOI] [PubMed] [Google Scholar]
  7. Falkenhagen U., Zingler G., Naumann G. Serum resistance in different serotypes of Escherichia coli. Zentralbl Bakteriol. 1991 Jun;275(2):216–222. doi: 10.1016/s0934-8840(11)80068-x. [DOI] [PubMed] [Google Scholar]
  8. Hughes C., Phillips R., Roberts A. P. Serum resistance among Escherichia coli strains causing urinary tract infection in relation to O type and the carriage of hemolysin, colicin, and antibiotic resistance determinants. Infect Immun. 1982 Jan;35(1):270–275. doi: 10.1128/iai.35.1.270-275.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jacobson S. H., Ostenson C. G., Tullus K., Brauner A. Serum resistance in Escherichia coli strains causing acute pyelonephritis and bacteraemia. APMIS. 1992 Feb;100(2):147–153. [PubMed] [Google Scholar]
  10. Johnson J. R. Virulence factors in Escherichia coli urinary tract infection. Clin Microbiol Rev. 1991 Jan;4(1):80–128. doi: 10.1128/cmr.4.1.80. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Karmali M. A. Infection by verocytotoxin-producing Escherichia coli. Clin Microbiol Rev. 1989 Jan;2(1):15–38. doi: 10.1128/cmr.2.1.15. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kubens B. S., Nikolai S., Opferkuch W. A third mechanism of serum resistance in Escherichia coli. Zentralbl Bakteriol. 1989 Jul;271(2):222–230. doi: 10.1016/s0934-8840(89)80076-3. [DOI] [PubMed] [Google Scholar]
  13. Kubens B. S., Opferkuch W. Studies on serum resistance in Escherichia coli. Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Nov;270(1-2):52–65. doi: 10.1016/s0176-6724(88)80141-x. [DOI] [PubMed] [Google Scholar]
  14. Kubens B. S., Wettstein M., Opferkuch W. Two different mechanisms of serum resistance in Escherichia coli. Microb Pathog. 1988 Nov;5(5):371–379. doi: 10.1016/0882-4010(88)90037-x. [DOI] [PubMed] [Google Scholar]
  15. Leying H., Suerbaum S., Kroll H. P., Stahl D., Opferkuch W. The capsular polysaccharide is a major determinant of serum resistance in K-1-positive blood culture isolates of Escherichia coli. Infect Immun. 1990 Jan;58(1):222–227. doi: 10.1128/iai.58.1.222-227.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McCabe W. R., Kaijser B., Olling S., Uwaydah M., Hanson L. A. Escherichia coli in bacteremia: K and O antigens and serum sensitivity of strains from adults and neonates. J Infect Dis. 1978 Jul;138(1):33–41. doi: 10.1093/infdis/138.1.33. [DOI] [PubMed] [Google Scholar]
  17. Miler I., Vondrácek J., Hromádková L. The bactericidal activity of sera of healthy neonates and of newborns with hyperbilirubinaemia to Escherichia coli. Folia Microbiol (Praha) 1979;24(2):143–152. doi: 10.1007/BF02927298. [DOI] [PubMed] [Google Scholar]
  18. Moll A., Manning P. A., Timmis K. N. Plasmid-determined resistance to serum bactericidal activity: a major outer membrane protein, the traT gene product, is responsible for plasmid-specified serum resistance in Escherichia coli. Infect Immun. 1980 May;28(2):359–367. doi: 10.1128/iai.28.2.359-367.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Ofek I., Sharon N. Lectinophagocytosis: a molecular mechanism of recognition between cell surface sugars and lectins in the phagocytosis of bacteria. Infect Immun. 1988 Mar;56(3):539–547. doi: 10.1128/iai.56.3.539-547.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Olling S., Hanson L. A., Holmgren J., Jodal U., Lincoln K., Lindberg U. The bactericidal effect of normal human serum on E. coli strains from normals and from patients with urinary tract infections. Infection. 1973;1(1):24–28. doi: 10.1007/BF01638251. [DOI] [PubMed] [Google Scholar]
  21. Orskov I., Orskov F. Escherichia coli in extra-intestinal infections. J Hyg (Lond) 1985 Dec;95(3):551–575. doi: 10.1017/s0022172400060678. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Roantree R. J., Rantz L. A. A STUDY OF THE RELATIONSHIP OF THE NORMAL BACTERICIDAL ACTIVITY OF HUMAN SERUM TO BACTERIAL INFECTION. J Clin Invest. 1960 Jan;39(1):72–81. doi: 10.1172/JCI104029. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Roberts I. S., Saunders F. K., Boulnois G. J. Bacterial capsules and interactions with complement and phagocytes. Biochem Soc Trans. 1989 Jun;17(3):462–464. doi: 10.1042/bst0170462. [DOI] [PubMed] [Google Scholar]
  24. Stawski G., Nielsen L., Orskov F., Orskov I. Serum sensitivity of a diversity of Escherichia coli antigenic reference strains. Correlation with an LPS variation phenomenon. APMIS. 1990 Sep;98(9):828–838. [PubMed] [Google Scholar]
  25. Tabouret M., De Rycke J., Audurier A., Poutrel B. Pathogenicity of Listeria monocytogenes isolates in immunocompromised mice in relation to listeriolysin production. J Med Microbiol. 1991 Jan;34(1):13–18. doi: 10.1099/00222615-34-1-13. [DOI] [PubMed] [Google Scholar]
  26. Taylor P. W. Bactericidal and bacteriolytic activity of serum against gram-negative bacteria. Microbiol Rev. 1983 Mar;47(1):46–83. doi: 10.1128/mr.47.1.46-83.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Vosti K. L., Randall E. Sensitivity of serologically classified strains of escherichia coli of human origin to the serum bactericidal system. Am J Med Sci. 1970 Feb;259(2):114–119. doi: 10.1097/00000441-197002000-00005. [DOI] [PubMed] [Google Scholar]

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