Abstract
Pseudomonas aeruginosa pneumonia causes a vasculitis of small pulmonary arteries. While the fully developed lesion demonstrates vessel wall necrosis, the early lesion is remarkable for preservation of viable endothelium despite vessel wall invasion by bacteria. Pyocyanin, an exoproduct of P. aeruginosa, markedly inhibited prostacyclin production by pulmonary artery endothelial cells without causing cell lysis. Pyocyanin might after vascular homeostasis in the absence of cytolysis.
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- Britigan B. E., Roeder T. L., Rasmussen G. T., Shasby D. M., McCormick M. L., Cox C. D. Interaction of the Pseudomonas aeruginosa secretory products pyocyanin and pyochelin generates hydroxyl radical and causes synergistic damage to endothelial cells. Implications for Pseudomonas-associated tissue injury. J Clin Invest. 1992 Dec;90(6):2187–2196. doi: 10.1172/JCI116104. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cox C. D. Role of pyocyanin in the acquisition of iron from transferrin. Infect Immun. 1986 Apr;52(1):263–270. doi: 10.1128/iai.52.1.263-270.1986. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Erlansson M., Bergqvist D., Persson N. H., Svensjo E. Modification of postischemic increase of leukocyte adhesion and vascular permeability in the hamster by Iloprost. Prostaglandins. 1991 Feb;41(2):157–168. doi: 10.1016/0090-6980(91)90028-e. [DOI] [PubMed] [Google Scholar]
- Fetzer A. E., Werner A. S., Hagstrom J. W. Pathologic features of pseudomonal pneumonia. Am Rev Respir Dis. 1967 Dec;96(6):1121–1130. doi: 10.1164/arrd.1967.96.6.1121. [DOI] [PubMed] [Google Scholar]
- Hempel S. L., Haycraft D. L., Hoak J. C., Spector A. A. Reduced prostacyclin formation after reoxygenation of anoxic endothelium. Am J Physiol. 1990 Nov;259(5 Pt 1):C738–C745. doi: 10.1152/ajpcell.1990.259.5.C738. [DOI] [PubMed] [Google Scholar]
- Kanthakumar K., Taylor G., Tsang K. W., Cundell D. R., Rutman A., Smith S., Jeffery P. K., Cole P. J., Wilson R. Mechanisms of action of Pseudomonas aeruginosa pyocyanin on human ciliary beat in vitro. Infect Immun. 1993 Jul;61(7):2848–2853. doi: 10.1128/iai.61.7.2848-2853.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kubes P., Suzuki M., Granger D. N. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci U S A. 1991 Jun 1;88(11):4651–4655. doi: 10.1073/pnas.88.11.4651. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McIntyre T. M., Zimmerman G. A., Satoh K., Prescott S. M. Cultured endothelial cells synthesize both platelet-activating factor and prostacyclin in response to histamine, bradykinin, and adenosine triphosphate. J Clin Invest. 1985 Jul;76(1):271–280. doi: 10.1172/JCI111957. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Muller M., Sorrell T. C. Leukotriene B4 omega-oxidation by human polymorphonuclear leukocytes is inhibited by pyocyanin, a phenazine derivative produced by Pseudomonas aeruginosa. Infect Immun. 1992 Jun;60(6):2536–2540. doi: 10.1128/iai.60.6.2536-2540.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Muller M., Sztelma K., Sorrell T. C. Inhibition of platelet eicosanoid metabolism by the bacterial phenazine derivative pyocyanin. Ann N Y Acad Sci. 1994 Nov 15;744:320–322. doi: 10.1111/j.1749-6632.1994.tb52752.x. [DOI] [PubMed] [Google Scholar]
- Sheldon R., Moy A., Lindsley K., Shasby S., Shasby D. M. Role of myosin light-chain phosphorylation in endothelial cell retraction. Am J Physiol. 1993 Dec;265(6 Pt 1):L606–L612. doi: 10.1152/ajplung.1993.265.6.L606. [DOI] [PubMed] [Google Scholar]
- TEPLITZ C. PATHOGENESIS OF PSEUDOMONAS VASCULITIS AND SEPTIC LEGIONS. Arch Pathol. 1965 Sep;80:297–307. [PubMed] [Google Scholar]
- Warren J. B., Loi R. K., Wilson A. J. PGD2 is an intermediate in agonist-stimulated nitric oxide release in rabbit skin microcirculation. Am J Physiol. 1994 May;266(5 Pt 2):H1846–H1853. doi: 10.1152/ajpheart.1994.266.5.H1846. [DOI] [PubMed] [Google Scholar]
- Warren J. B., Loi R., Rendell N. B., Taylor G. W. Nitric oxide is inactivated by the bacterial pigment pyocyanin. Biochem J. 1990 Mar 15;266(3):921–923. [PMC free article] [PubMed] [Google Scholar]