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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 2000 Oct;69(4):464–471. doi: 10.1136/jnnp.69.4.464

Incidence of brain tumours in two English counties: a population based study

L Pobereskin 1, J Chadduck 1
PMCID: PMC1737141  PMID: 10990505

Abstract

OBJECTIVE—To define the incidence of brain tumours in Devon and Cornwall and to discover which case finding methods are the most fruitful. To examine what happens to patients after the diagnosis of a brain tumour.
METHODS—The primary method of case ascertainment was a review of all CT with contrast and MRI of the head performed on the population of Devon and Cornwall between 1 April 1992 and 31 March 1997.Secondary sources included registrations with the South and West Cancer Intelligence Unit and a search for all patients either admitted to hospital with a brain tumour or operated on for a brain tumour during the same period.
RESULTS—16 923 scans were reviewed of which 8774 (52%) were normal. The scan review found 2483 incident intracranial tumours, of which 861 were metastases. Secondary sources of case ascertainment disclosed 46 further cases. Cases were missed by the scan review mainly for technical reasons and only three patients were found who were diagnosed by non-imaging methods. The incidence of primary intracranial tumours standardised to the population of England and Wales was higher than any previously reported (21.04 (17.18-25.62)/100 000person-years). Overall, 21% of cases were not admitted to hospital. The categories least likely to be admitted were those with sellar and cranial nerve tumours. Those not admitted to hospital were significantly older than those who were.
CONCLUSION—One fifth of patients are not admitted to hospital after the diagnosis of a brain tumour and incidence studies must use case finding methods which will capture these cases. An audit of imaging results provides almost complete case ascertainment. This study shows that the incidence of primary brain tumours is considerably higher than previously thought. Official figures from the cancer intelligence units significantly underestimate brain tumour incidence, especially for benign tumours.



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Selected References

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  1. Barker D. J., Weller R. O., Garfield J. S. Epidemiology of primary tumours of the brain and spinal cord: a regional survey in southern England. J Neurol Neurosurg Psychiatry. 1976 Mar;39(3):290–296. doi: 10.1136/jnnp.39.3.290. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cole G. C., Wilkins P. R., West R. R. An epidemiological survey of primary tumours of the brain and spinal cord in South East Wales. Br J Neurosurg. 1989;3(4):487–493. doi: 10.3109/02688698909002835. [DOI] [PubMed] [Google Scholar]
  3. Counsell C. E., Collie D. A., Grant R. Incidence of intracranial tumours in the Lothian region of Scotland, 1989-90. J Neurol Neurosurg Psychiatry. 1996 Aug;61(2):143–150. doi: 10.1136/jnnp.61.2.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Counsell C. E., Grant R. Incidence studies of primary and secondary intracranial tumors: a systematic review of their methodology and results. J Neurooncol. 1998 May;37(3):241–250. doi: 10.1023/a:1005861024679. [DOI] [PubMed] [Google Scholar]
  5. Davis D. L., Ahlbom A., Hoel D., Percy C. Is brain cancer mortality increasing in industrial countries? Am J Ind Med. 1991;19(4):421–431. doi: 10.1002/ajim.4700190402. [DOI] [PubMed] [Google Scholar]
  6. Davis F. G., Malinski N., Haenszel W., Chang J., Flannery J., Gershman S., Dibble R., Bigner D. D. Primary brain tumor incidence rates in four United States regions, 1985-1989: a pilot study. Neuroepidemiology. 1996;15(2):103–112. doi: 10.1159/000109895. [DOI] [PubMed] [Google Scholar]
  7. Gill L., Goldacre M., Simmons H., Bettley G., Griffith M. Computerised linking of medical records: methodological guidelines. J Epidemiol Community Health. 1993 Aug;47(4):316–319. doi: 10.1136/jech.47.4.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Helseth A. The incidence of primary central nervous system neoplasms before and after computerized tomography availability. J Neurosurg. 1995 Dec;83(6):999–1003. doi: 10.3171/jns.1995.83.6.0999. [DOI] [PubMed] [Google Scholar]
  9. Kendall B. E., Jakubowski J., Pullicino P., Symon L. Difficulties in diagnosis of supratentorial gliomas by CAT scan. J Neurol Neurosurg Psychiatry. 1979 Jun;42(6):485–492. doi: 10.1136/jnnp.42.6.485. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kurland L. T., Schoenberg B. S., Annegers J. F., Okazaki H., Molgaard C. A. The incidence of primary intracranial neoplasms in Rochester, Minnesota, 1935-1977. Ann N Y Acad Sci. 1982;381:6–16. doi: 10.1111/j.1749-6632.1982.tb50361.x. [DOI] [PubMed] [Google Scholar]
  11. Todd N. V., McDonagh T., Miller J. D. What follows diagnosis by computed tomography of solitary brain tumour? Audit of one year's experience in South East Scotland. Lancet. 1987 Mar 14;1(8533):611–612. doi: 10.1016/s0140-6736(87)90244-3. [DOI] [PubMed] [Google Scholar]
  12. Tola M. R., Casetta I., Granieri E., Pinna L., Veronesi V., Tamarozzi R., Trapella G., Monetti V. C., Paolino E., Govoni V. Intracranial gliomas in Ferrara, Italy, 1976 to 1991. Acta Neurol Scand. 1994 Nov;90(5):312–317. doi: 10.1111/j.1600-0404.1994.tb02730.x. [DOI] [PubMed] [Google Scholar]

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