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. 2000 Oct;69(4):507–511. doi: 10.1136/jnnp.69.4.507

Long term decline of P100 amplitude in migraine with aura

N Khalil 1, N Legg 1, D Anderson 1
PMCID: PMC1737153  PMID: 10990512

Abstract

OBJECTIVES—To investigate visual function in migraine using visual evoked potentials.
METHODS—Electroretinograms (ERGs) and visual evoked potentials (VEPs) to single flash (SF) and pattern reversal (PR) stimuli were studied in 92 migraine subjects and 62controls.
RESULTS—In subjects with migraine, ERGs to single flash were normal. Mean latencies of the P1 and P2 waves in the SFVEP were increased at the occiput by 6% and 4% respectively, but normal at the vertex. Mean latency of the P100 wave in the PRVEP was increased by 5%. These increases were not related to the presence or absence of an aura or to the duration of migraine. P100 amplitude showed a more complex abnormality. It was increased in migraine without aura by 23% compared with controls, regardless of duration of migraine. In migraine with aura it was similarly increased, by 23%, in cases of short duration, but in addition it showed a sharp decline with duration. In cases with a duration of 30 or more years it was 36% less than in cases of short duration, and 21% less than in controls.
CONCLUSIONS—Subjects with migraine have constitutionally prolonged VEP latencies and increased P100 amplitude, but the latter declines to below normal in cases with a long history of migraine with aura. This decline may reflect subtle neuronal damage within the visual system from repeated transient ischaemia experienced during the aura. Future electrophysiological and other studies will need to be controlled for duration of migraine history.



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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Afra J., Cecchini A. P., De Pasqua V., Albert A., Schoenen J. Visual evoked potentials during long periods of pattern-reversal stimulation in migraine. Brain. 1998 Feb;121(Pt 2):233–241. doi: 10.1093/brain/121.2.233. [DOI] [PubMed] [Google Scholar]
  2. Afra J., Mascia A., Gérard P., Maertens de Noordhout A., Schoenen J. Interictal cortical excitability in migraine: a study using transcranial magnetic stimulation of motor and visual cortices. Ann Neurol. 1998 Aug;44(2):209–215. doi: 10.1002/ana.410440211. [DOI] [PubMed] [Google Scholar]
  3. Aurora S. K., Ahmad B. K., Welch K. M., Bhardhwaj P., Ramadan N. M. Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine. Neurology. 1998 Apr;50(4):1111–1114. doi: 10.1212/wnl.50.4.1111. [DOI] [PubMed] [Google Scholar]
  4. Aurora S. K., Cao Y., Bowyer S. M., Welch K. M. The occipital cortex is hyperexcitable in migraine: experimental evidence. Headache. 1999 Jul-Aug;39(7):469–476. doi: 10.1046/j.1526-4610.1999.3907469.x. [DOI] [PubMed] [Google Scholar]
  5. Benna P., Bianco C., Costa P., Piazza D., Bergamasco B. Visual evoked potentials and brainstem auditory evoked potentials in migraine and transient ischemic attacks. Cephalalgia. 1985 May;5 (Suppl 2):53–58. doi: 10.1177/03331024850050S209. [DOI] [PubMed] [Google Scholar]
  6. Chronicle E., Mulleners W. Might migraine damage the brain? Cephalalgia. 1994 Dec;14(6):415–418. doi: 10.1046/j.1468-2982.1994.1406415.x. [DOI] [PubMed] [Google Scholar]
  7. Drake M. E., Pakalnis A., Hietter S. A., Padamadan H. Visual and auditory evoked potentials in migraine. Electromyogr Clin Neurophysiol. 1990 Feb-Mar;30(2):77–81. [PubMed] [Google Scholar]
  8. GOLLA F. L., WINTER A. L. Analysis of cerebral responses to flicker in patients complaining of episodic headache. Electroencephalogr Clin Neurophysiol. 1959 Aug;11(3):539–549. doi: 10.1016/0013-4694(59)90052-5. [DOI] [PubMed] [Google Scholar]
  9. Heider W., Berninger T., Brunk G. Elektroophthalmologische und klinische Beobachtungen bei chronischem Ergotaminabusus. Fortschr Ophthalmol. 1986;83(5):539–541. [PubMed] [Google Scholar]
  10. Jones S. J., Turano G., Kriss A., Shawkat F., Kendall B., Thompson A. J. Visual evoked potentials in phenylketonuria: association with brain MRI, dietary state, and IQ. J Neurol Neurosurg Psychiatry. 1995 Sep;59(3):260–265. doi: 10.1136/jnnp.59.3.260. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jonkman E. J., Lelieveld M. H. EEG computer analysis in patients with migraine. Electroencephalogr Clin Neurophysiol. 1981 Dec;52(6):652–655. doi: 10.1016/0013-4694(81)91440-1. [DOI] [PubMed] [Google Scholar]
  12. Kennard C., Gawel M., Rudolph N. de M., Rose F. C. Visual evoked potentials in migraine subjects. Res Clin Stud Headache. 1978;6:73–80. [PubMed] [Google Scholar]
  13. Lauritzen M., Skyhøj Olsen T., Lassen N. A., Paulson O. B. Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol. 1983 Jun;13(6):633–641. doi: 10.1002/ana.410130609. [DOI] [PubMed] [Google Scholar]
  14. Lehtonen J. B. Visual evoked cortical potentials for single flashes and flickering light in migraine. Headache. 1974 Apr;14(1):1–12. doi: 10.1111/j.1526-4610.1974.hed1401001.x. [DOI] [PubMed] [Google Scholar]
  15. Maertens de Noordhout A., Pepin J. L., Schoenen J., Delwaide P. J. Percutaneous magnetic stimulation of the motor cortex in migraine. Electroencephalogr Clin Neurophysiol. 1992 Apr;85(2):110–115. doi: 10.1016/0168-5597(92)90076-n. [DOI] [PubMed] [Google Scholar]
  16. Olesen J., Larsen B., Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol. 1981 Apr;9(4):344–352. doi: 10.1002/ana.410090406. [DOI] [PubMed] [Google Scholar]
  17. Ongkosuwito J. V., Kortbeek L. M., Van der Lelij A., Molicka E., Kijlstra A., de Smet M. D., Suttorp-Schulten M. S. Aetiological study of the presumed ocular histoplasmosis syndrome in the Netherlands. Br J Ophthalmol. 1999 May;83(5):535–539. doi: 10.1136/bjo.83.5.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Polich J., Ehlers C. L., Dalessio D. J. Pattern-shift visual evoked responses and EEG in migraine. Headache. 1986 Oct;26(9):451–456. doi: 10.1111/j.1526-4610.1986.hed2609451.x. [DOI] [PubMed] [Google Scholar]
  19. Richey E. T., Kooi K. A., Waggoner R. W. Visually evoked responses in migraine. Electroencephalogr Clin Neurophysiol. 1966 Jul;21(1):23–27. doi: 10.1016/0013-4694(66)90055-1. [DOI] [PubMed] [Google Scholar]
  20. Rossi L. N., Pastorino G. C., Bellettini G., Chiodi A., Mariani E., Cortinovis I. Pattern reversal visual evoked potentials in children with migraine or tension-type headache. Cephalalgia. 1996 Apr;16(2):104–106. doi: 10.1046/j.1468-2982.1996.1602104.x. [DOI] [PubMed] [Google Scholar]
  21. Schafer E. W., McKean C. M. Evidence that monoamines influence human evoked potentials. Brain Res. 1975 Nov 28;99(1):49–58. doi: 10.1016/0006-8993(75)90607-1. [DOI] [PubMed] [Google Scholar]
  22. Sener H. O., Haktanir I., Demirci S. Pattern-reversal visual evoked potentials in migraineurs with or without visual aura. Headache. 1997 Jul-Aug;37(7):449–451. doi: 10.1046/j.1526-4610.1997.3707449.x. [DOI] [PubMed] [Google Scholar]
  23. Shibata K., Osawa M., Iwata M. Simultaneous recording of pattern reversal electroretinograms and visual evoked potentials in migraine. Cephalalgia. 1997 Nov;17(7):742–747. doi: 10.1046/j.1468-2982.1997.1707742.x. [DOI] [PubMed] [Google Scholar]
  24. Skyhøj Olsen T., Friberg L., Lassen N. A. Ischemia may be the primary cause of the neurologic deficits in classic migraine. Arch Neurol. 1987 Feb;44(2):156–161. doi: 10.1001/archneur.1987.00520140028013. [DOI] [PubMed] [Google Scholar]
  25. Wang W., Timsit-Berthier M., Schoenen J. Intensity dependence of auditory evoked potentials is pronounced in migraine: an indication of cortical potentiation and low serotonergic neurotransmission? Neurology. 1996 May;46(5):1404–1409. doi: 10.1212/wnl.46.5.1404. [DOI] [PubMed] [Google Scholar]
  26. Welch K. M., Barkley G. L., Ramadan N. M., D'Andrea G. NMR spectroscopic and magnetoencephalographic studies in migraine with aura: support for the spreading depression hypothesis. Pathol Biol (Paris) 1992 Apr;40(4):349–354. [PubMed] [Google Scholar]
  27. van der Kamp W., Maassen VanDenBrink A., Ferrari M. D., van Dijk J. G. Interictal cortical hyperexcitability in migraine patients demonstrated with transcranial magnetic stimulation. J Neurol Sci. 1996 Jul;139(1):106–110. doi: 10.1016/s0022-510x(96)00044-5. [DOI] [PubMed] [Google Scholar]

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