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. 1996 Feb;64(2):611–615. doi: 10.1128/iai.64.2.611-615.1996

Rapid cyclic changes in density and accessibility of endometrial ligands for Escherichia coli Dr fimbriae.

A K Kaul 1, D Kumar 1, M Nagamani 1, P Goluszko 1, S Nowicki 1, B J Nowicki 1
PMCID: PMC173809  PMID: 8550215

Abstract

The mechanisms of developing infection in young, noncompromised individuals are well understood. Colonization is prerequisite for the development of infection. In human, ligands serving bacterial colonization belong to common antigens. Consequently, a majority of individuals should be sensitive to infection at all times. We hypothesize that the temporal patterns of some infections and sensitivity to them are associated with sudden changes in the density and accessibility of common receptors. Endometrial samples from women having normal menstrual cycles were examined for histological location, receptor density, and in situ hybridization of Dr (decaying-accelerating factor) ligands for Escherichia coli Dr fimbriae. Significant up-regulation and luminal expression of Dr ligands occurred during the secretory phase, whereas receptors were expressed in the basement membrane and in smaller quantities during the proliferative phase. This observation agrees with our hypotheses that some ligands recognized by bacterial adhesins change their compartmentalization and, most importantly, that they up-regulate expression at specific times.

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Selected References

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  1. Beachey E. H. Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surface. J Infect Dis. 1981 Mar;143(3):325–345. doi: 10.1093/infdis/143.3.325. [DOI] [PubMed] [Google Scholar]
  2. Franklin W. A., Bibbo M., Doria M. I., Dytch H. E., Toth J., DeSombre E., Wied G. L. Quantitation of estrogen receptor content and Ki-67 staining in breast carcinoma by the microTICAS image analysis system. Anal Quant Cytol Histol. 1987 Aug;9(4):279–286. [PubMed] [Google Scholar]
  3. Gibbs R. S. Pelvic inflammatory disease in adolescents. Tex Med. 1987 Feb;83(2):5–6. [PubMed] [Google Scholar]
  4. Johnson D. W., Holmes K. K., Kvale P. A., Halverson C. W., Hirsch W. P. An evaluation of gonorrhea case findings in the chronically infected female. Am J Epidemiol. 1969 Nov;90(5):438–448. doi: 10.1093/oxfordjournals.aje.a121090. [DOI] [PubMed] [Google Scholar]
  5. Karr J. F., Nowicki B. J., Truong L. D., Hull R. A., Moulds J. J., Hull S. I. pap-2-encoded fimbriae adhere to the P blood group-related glycosphingolipid stage-specific embryonic antigen 4 in the human kidney. Infect Immun. 1990 Dec;58(12):4055–4062. doi: 10.1128/iai.58.12.4055-4062.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kaul A., Nagamani M., Nowicki B. Decreased expression of endometrial decay accelerating factor (DAF), a complement regulatory protein, in patients with luteal phase defect. Am J Reprod Immunol. 1995 Oct;34(4):236–240. doi: 10.1111/j.1600-0897.1995.tb00947.x. [DOI] [PubMed] [Google Scholar]
  7. Kaul A., Nowicki B. J., Martens M. G., Goluszko P., Hart A., Nagamani M., Kumar D., Pham T. Q., Nowicki S. Decay-accelerating factor is expressed in the human endometrium and may serve as the attachment ligand for Dr pili of Escherichia coli. Am J Reprod Immunol. 1994 Oct;32(3):194–199. doi: 10.1111/j.1600-0897.1994.tb01114.x. [DOI] [PubMed] [Google Scholar]
  8. Lublin D. M., Atkinson J. P. Decay-accelerating factor: biochemistry, molecular biology, and function. Annu Rev Immunol. 1989;7:35–58. doi: 10.1146/annurev.iy.07.040189.000343. [DOI] [PubMed] [Google Scholar]
  9. Lund B., Marklund B. I., Strömberg N., Lindberg F., Karlsson K. A., Normark S. Uropathogenic Escherichia coli can express serologically identical pili of different receptor binding specificities. Mol Microbiol. 1988 Mar;2(2):255–263. doi: 10.1111/j.1365-2958.1988.tb00027.x. [DOI] [PubMed] [Google Scholar]
  10. McCormack W. M., Reynolds G. H. Effect of menstrual cycle and method of contraception on recovery of Neisseria gonorrhoeae. JAMA. 1982 Mar 5;247(9):1292–1294. [PubMed] [Google Scholar]
  11. Nicholson-Weller A., Burge J., Fearon D. T., Weller P. F., Austen K. F. Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system. J Immunol. 1982 Jul;129(1):184–189. [PubMed] [Google Scholar]
  12. Nowicki B., Hart A., Coyne K. E., Lublin D. M., Nowicki S. Short consensus repeat-3 domain of recombinant decay-accelerating factor is recognized by Escherichia coli recombinant Dr adhesin in a model of a cell-cell interaction. J Exp Med. 1993 Dec 1;178(6):2115–2121. doi: 10.1084/jem.178.6.2115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nowicki B., Hull R., Moulds J. Use of the Dr hemagglutinin of uropathogenic Escherichia coli to differentiate normal from abnormal red cells in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1988 Nov 10;319(19):1289–1290. doi: 10.1056/NEJM198811103191916. [DOI] [PubMed] [Google Scholar]
  14. Nowicki B., Martens M., Hart A., Nowicki S. Gestational age-dependent distribution of Escherichia coli fimbriae in pregnant patients with pyelonephritis. Ann N Y Acad Sci. 1994 Aug 15;730:290–291. doi: 10.1111/j.1749-6632.1994.tb44268.x. [DOI] [PubMed] [Google Scholar]
  15. Nowicki B., Moulds J., Hull R., Hull S. A hemagglutinin of uropathogenic Escherichia coli recognizes the Dr blood group antigen. Infect Immun. 1988 May;56(5):1057–1060. doi: 10.1128/iai.56.5.1057-1060.1988. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Rutter J. M., Burrows M. R., Sellwood R., Gibbons R. A. A genetic basis for resistance to enteric disease caused by E. coli. Nature. 1975 Sep 11;257(5522):135–136. doi: 10.1038/257135a0. [DOI] [PubMed] [Google Scholar]
  17. Spring F. A., Judson P. A., Daniels G. L., Parsons S. F., Mallinson G., Anstee D. J. A human cell-surface glycoprotein that carries Cromer-related blood group antigens on erythrocytes and is also expressed on leucocytes and platelets. Immunology. 1987 Oct;62(2):307–313. [PMC free article] [PubMed] [Google Scholar]
  18. Sweet R. L., Blankfort-Doyle M., Robbie M. O., Schacter J. The occurrence of chlamydial and gonococcal salpingitis during the menstrual cycle. JAMA. 1986 Apr 18;255(15):2062–2064. [PubMed] [Google Scholar]
  19. Sweet R. L., Draper D. L., Schachter J., James J., Hadley W. K., Brooks G. F. Microbiology and pathogenesis of acute salpingitis as determined by laparoscopy: what is the appropriate site to sample? Am J Obstet Gynecol. 1980 Dec 1;138(7 Pt 2):985–989. doi: 10.1016/0002-9378(80)91093-5. [DOI] [PubMed] [Google Scholar]
  20. Telen M. J., Hall S. E., Green A. M., Moulds J. J., Rosse W. F. Identification of human erythrocyte blood group antigens on decay-accelerating factor (DAF) and an erythrocyte phenotype negative for DAF. J Exp Med. 1988 Jun 1;167(6):1993–1998. doi: 10.1084/jem.167.6.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Westerlund B., Kuusela P., Risteli J., Risteli L., Vartio T., Rauvala H., Virkola R., Korhonen T. K. The O75X adhesin of uropathogenic Escherichia coli is a type IV collagen-binding protein. Mol Microbiol. 1989 Mar;3(3):329–337. doi: 10.1111/j.1365-2958.1989.tb00178.x. [DOI] [PubMed] [Google Scholar]

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