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. 1996 Feb;64(2):665–667. doi: 10.1128/iai.64.2.665-667.1996

Persistence of serum and salivary antibody responses after oral immunization with a bacterial protein antigen genetically linked to the A2/B subunits of cholera toxin.

G Hajishengallis 1, S M Michalek 1, M W Russell 1
PMCID: PMC173818  PMID: 8550224

Abstract

Primary oral immunization of mice with a bacterial protein antigen genetically coupled to the A2 and B subunits of cholera toxin induced specific secretory immunoglobulin A and serum immunoglobulin G antibodies that persisted at substantial levels for at least 11 months. A subsequent single booster immunization did not further enhance the antibody responses. Long-term antibody persistence may be especially important in infections caused by common pathogens for which continuous immunity would be advantageous.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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