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. 1996 Mar;64(3):829–835. doi: 10.1128/iai.64.3.829-835.1996

Invasin of Yersinia pseudotuberculosis activates human peripheral B cells.

E Lundgren 1, N Carballeira 1, R Vazquez 1, E Dubinina 1, H Bränden 1, H Persson 1, H Wolf-Watz 1
PMCID: PMC173844  PMID: 8641788

Abstract

The Yersinia pseudotuberculosis cell surface-located protein invasin was found to promote binding between the pathogen and resting peripheral B cells via beta 1 integrin receptors (CD29). B cells responded by expressing several activation markers and by growing, In contrast, T cells did not react, although these cells express CD29. An isogenic invA mutant failed to activate B cells. The mutation could be complemented by providing the invA+ gene in trans. Purified invasin alone did not activate B cells, although it was able to block the binding of bacteria to the cells.

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Selected References

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