Abstract
Primitive reflexes are typically present in childhood, suppressed during normal development, and may reappear with diseases of the brain, particularly those affecting the frontal lobes. In this review we discuss some historical aspects surrounding these reflexes, how they might be elicited and interpreted, and their potential clinical utility in modern neurological practice.
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- Brown D. L., Smith T. L., Knepper L. E. Evaluation of five primitive reflexes in 240 young adults. Neurology. 1998 Jul;51(1):322–322. doi: 10.1212/wnl.51.1.322. [DOI] [PubMed] [Google Scholar]
- DENNY-BROWN D. The nature of apraxia. J Nerv Ment Dis. 1958 Jan;126(1):9–32. doi: 10.1097/00005053-195801000-00003. [DOI] [PubMed] [Google Scholar]
- De Renzi E., Barbieri C. The incidence of the grasp reflex following hemispheric lesion and its relation to frontal damage. Brain. 1992 Feb;115(Pt 1):293–313. doi: 10.1093/brain/115.1.293. [DOI] [PubMed] [Google Scholar]
- EKBOM K. A., JERNELIUS B., KUGELBERG E. Perioral reflexes. Neurology. 1952 Mar-Apr;2(2):103–111. doi: 10.1212/wnl.2.5-6.103. [DOI] [PubMed] [Google Scholar]
- Eslinger Paul J. The anatomic basis of utilisation behaviour: a shift from frontal-parietal to intra-frontal mechanisms. Cortex. 2002 Jun;38(3):273–276. doi: 10.1016/s0010-9452(08)70658-0. [DOI] [PubMed] [Google Scholar]
- FISHER C. M. Reflex blepharospasm. Neurology. 1963 Jan;13:77–78. doi: 10.1212/wnl.13.1.77. [DOI] [PubMed] [Google Scholar]
- GARLAND H. G. Parkinsonism. Br Med J. 1952 Jan 19;1(4750):153–156. doi: 10.1136/bmj.1.4750.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Guberman A. Clinical significance of the corneomandibular reflex. Arch Neurol. 1982 Sep;39(9):578–580. doi: 10.1001/archneur.1982.00510210048011. [DOI] [PubMed] [Google Scholar]
- Hashimoto R., Tanaka Y. Contribution of the supplementary motor area and anterior cingulate gyrus to pathological grasping phenomena. Eur Neurol. 1998 Oct;40(3):151–158. doi: 10.1159/000007972. [DOI] [PubMed] [Google Scholar]
- Isakov E., Sazbon L., Costeff H., Luz Y., Najenson T. The diagnostic value of three common primitive reflexes. Eur Neurol. 1984;23(1):17–21. doi: 10.1159/000115672. [DOI] [PubMed] [Google Scholar]
- Jenkyn L. R., Reeves A. G., Warren T., Whiting R. K., Clayton R. J., Moore W. W., Rizzo A., Tuzun I. M., Bonnett J. C., Culpepper B. W. Neurologic signs in senescence. Arch Neurol. 1985 Dec;42(12):1154–1157. doi: 10.1001/archneur.1985.04060110036012. [DOI] [PubMed] [Google Scholar]
- Jenkyn L. R., Walsh D. B., Walsh B. T., Culver C. M., Reeves A. G. The nuchocephalic reflex. J Neurol Neurosurg Psychiatry. 1975 Jun;38(6):561–566. doi: 10.1136/jnnp.38.6.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jensen J. P., Grøn U., Pakkenberg H. Comparison of three primitive reflexes in neurological patients and in normal individuals. J Neurol Neurosurg Psychiatry. 1983 Feb;46(2):162–167. doi: 10.1136/jnnp.46.2.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kobayashi S., Yamaguchi S., Okada K., Yamashita K. Primitive reflexes and MRI findings, cerebral blood flow in normal elderly. Gerontology. 1990;36(4):199–205. doi: 10.1159/000213200. [DOI] [PubMed] [Google Scholar]
- Leibowitz U., Sharon D., Alter M. Geographical considerations in multiple sclerosis. Brain. 1968 Mar;91(1):37–52. doi: 10.1093/brain/91.1.37. [DOI] [PubMed] [Google Scholar]
- Lhermitte F. 'Utilization behaviour' and its relation to lesions of the frontal lobes. Brain. 1983 Jun;106(Pt 2):237–255. doi: 10.1093/brain/106.2.237. [DOI] [PubMed] [Google Scholar]
- Okuda B., Kodama N., Kawabata K., Tachibana H., Sugita M. Corneomandibular reflex in ALS. Neurology. 1999 May 12;52(8):1699–1701. doi: 10.1212/wnl.52.8.1699. [DOI] [PubMed] [Google Scholar]
- Owen G., Mulley G. P. The palmomental reflex: a useful clinical sign? J Neurol Neurosurg Psychiatry. 2002 Aug;73(2):113–115. doi: 10.1136/jnnp.73.2.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Paulson G. W. The neurological examination in dementia. Contemp Neurol Ser. 1977;15:169–188. [PubMed] [Google Scholar]
- Pearce J., Aziz H., Gallagher J. C. Primitive reflex activity in primary and symptomatic Parkinsonism. J Neurol Neurosurg Psychiatry. 1968 Oct;31(5):501–508. doi: 10.1136/jnnp.31.5.501. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shallice T., Burgess P. W., Schon F., Baxter D. M. The origins of utilization behaviour. Brain. 1989 Dec;112(Pt 6):1587–1598. doi: 10.1093/brain/112.6.1587. [DOI] [PubMed] [Google Scholar]
- Thomas R. J. Blinking and the release reflexes: are they clinically useful? J Am Geriatr Soc. 1994 Jun;42(6):609–613. doi: 10.1111/j.1532-5415.1994.tb06858.x. [DOI] [PubMed] [Google Scholar]