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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 2003 Jun;74(6):720–724. doi: 10.1136/jnnp.74.6.720

Dementia with Lewy bodies according to the consensus criteria in a general population aged 75 years or older

T Rahkonen 1, U Eloniemi-Sulkava 1, S Rissanen 1, A Vatanen 1, P Viramo 1, R Sulkava 1
PMCID: PMC1738491  PMID: 12754338

Abstract

Objective: To estimate the prevalence of dementia with Lewy bodies (DLB) according to the consensus criteria in a general population aged 75 years or older.

Methods: The "Kuopio 75+ study" is a population based health survey focused on the clinical epidemiology of dementia and functional capacity among elderly subjects aged 75 years or older. On 1 January 1998, a random sample of 700 subjects was drawn from a total population born before 1 January 1923, living in the city of Kuopio, northeast Finland (n = 4518). The study subjects underwent a structured interview and clinical examination.

Results: 601 elderly subjects (86% of the random sample) were examined. A dementia disorder was diagnosed in 137—a prevalence of 22.8% (95% confidence interval 19.4% to 26.2%). The prevalence of DLB was 5.0% (3.2% to 6.7%), comprising 22% of all demented subjects. Probable DLB was diagnosed in 20 subjects (3.3% (1.9% to 4.8%)), and possible DLB in 10 (1.7% (0.6% to 2.7%)). The prevalence of Alzheimer's disease was 10.6% (47% of all demented subjects), of vascular dementia, 5.3% (23%), and of other types of dementing disorders, 1.8% (8%).

Conclusions: In a general population aged 75 years and older, the prevalence of a disorder fulfilling the diagnostic criteria of DLB is half that of Alzheimer's disease and the same as for vascular dementia.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Copeland J. R., Davidson I. A., Dewey M. E., Gilmore C., Larkin B. A., McWilliam C., Saunders P. A., Scott A., Sharma V., Sullivan C. Alzheimer's disease, other dementias, depression and pseudodementia: prevalence, incidence and three-year outcome in Liverpool. Br J Psychiatry. 1992 Aug;161:230–239. doi: 10.1192/bjp.161.2.230. [DOI] [PubMed] [Google Scholar]
  2. Erkinjuntti T., Ostbye T., Steenhuis R., Hachinski V. The effect of different diagnostic criteria on the prevalence of dementia. N Engl J Med. 1997 Dec 4;337(23):1667–1674. doi: 10.1056/NEJM199712043372306. [DOI] [PubMed] [Google Scholar]
  3. Fillenbaum G. G., Heyman A., Huber M. S., Woodbury M. A., Leiss J., Schmader K. E., Bohannon A., Trapp-Moen B. The prevalence and 3-year incidence of dementia in older Black and White community residents. J Clin Epidemiol. 1998 Jul;51(7):587–595. doi: 10.1016/s0895-4356(98)00024-9. [DOI] [PubMed] [Google Scholar]
  4. Folstein M. F., Folstein S. E., McHugh P. R. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975 Nov;12(3):189–198. doi: 10.1016/0022-3956(75)90026-6. [DOI] [PubMed] [Google Scholar]
  5. Fratiglioni L., Grut M., Forsell Y., Viitanen M., Grafström M., Holmén K., Ericsson K., Bäckman L., Ahlbom A., Winblad B. Prevalence of Alzheimer's disease and other dementias in an elderly urban population: relationship with age, sex, and education. Neurology. 1991 Dec;41(12):1886–1892. doi: 10.1212/wnl.41.12.1886. [DOI] [PubMed] [Google Scholar]
  6. Hohl U., Tiraboschi P., Hansen L. A., Thal L. J., Corey-Bloom J. Diagnostic accuracy of dementia with Lewy bodies. Arch Neurol. 2000 Mar;57(3):347–351. doi: 10.1001/archneur.57.3.347. [DOI] [PubMed] [Google Scholar]
  7. Holmes C., Cairns N., Lantos P., Mann A. Validity of current clinical criteria for Alzheimer's disease, vascular dementia and dementia with Lewy bodies. Br J Psychiatry. 1999 Jan;174:45–50. doi: 10.1192/bjp.174.1.45. [DOI] [PubMed] [Google Scholar]
  8. Juva K., Sulkava R., Erkinjuntti T., Valvanne J., Tilvis R. Prevalence of dementia in the city of Helsinki. Acta Neurol Scand. 1993 Feb;87(2):106–110. doi: 10.1111/j.1600-0404.1993.tb04086.x. [DOI] [PubMed] [Google Scholar]
  9. Lawton M. P., Brody E. M. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969 Autumn;9(3):179–186. [PubMed] [Google Scholar]
  10. Lippa C. F., Smith T. W., Swearer J. M. Alzheimer's disease and Lewy body disease: a comparative clinicopathological study. Ann Neurol. 1994 Jan;35(1):81–88. doi: 10.1002/ana.410350113. [DOI] [PubMed] [Google Scholar]
  11. Litvan I., MacIntyre A., Goetz C. G., Wenning G. K., Jellinger K., Verny M., Bartko J. J., Jankovic J., McKee A., Brandel J. P. Accuracy of the clinical diagnoses of Lewy body disease, Parkinson disease, and dementia with Lewy bodies: a clinicopathologic study. Arch Neurol. 1998 Jul;55(7):969–978. doi: 10.1001/archneur.55.7.969. [DOI] [PubMed] [Google Scholar]
  12. Lobo A., Saz P., Marcos G., Día J. L., De-la-Cámara C. The prevalence of dementia and depression in the elderly community in a southern European population. The Zaragoza study. Arch Gen Psychiatry. 1995 Jun;52(6):497–506. doi: 10.1001/archpsyc.1995.03950180083011. [DOI] [PubMed] [Google Scholar]
  13. Lopez O. L., Litvan I., Catt K. E., Stowe R., Klunk W., Kaufer D. I., Becker J. T., DeKosky S. T. Accuracy of four clinical diagnostic criteria for the diagnosis of neurodegenerative dementias. Neurology. 1999 Oct 12;53(6):1292–1299. doi: 10.1212/wnl.53.6.1292. [DOI] [PubMed] [Google Scholar]
  14. MAHONEY F. I., BARTHEL D. W. FUNCTIONAL EVALUATION: THE BARTHEL INDEX. Md State Med J. 1965 Feb;14:61–65. [PubMed] [Google Scholar]
  15. McKeith I. G., Ballard C. G., Perry R. H., Ince P. G., O'Brien J. T., Neill D., Lowery K., Jaros E., Barber R., Thompson P. Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology. 2000 Mar 14;54(5):1050–1058. doi: 10.1212/wnl.54.5.1050. [DOI] [PubMed] [Google Scholar]
  16. McKeith I. G., Galasko D., Kosaka K., Perry E. K., Dickson D. W., Hansen L. A., Salmon D. P., Lowe J., Mirra S. S., Byrne E. J. Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshop. Neurology. 1996 Nov;47(5):1113–1124. doi: 10.1212/wnl.47.5.1113. [DOI] [PubMed] [Google Scholar]
  17. McKeith I. G., O'Brien J. T., Ballard C. Diagnosing dementia with Lewy bodies. Lancet. 1999 Oct 9;354(9186):1227–1228. doi: 10.1016/S0140-6736(99)90214-3. [DOI] [PubMed] [Google Scholar]
  18. Mega M. S., Masterman D. L., Benson D. F., Vinters H. V., Tomiyasu U., Craig A. H., Foti D. J., Kaufer D., Scharre D. W., Fairbanks L. Dementia with Lewy bodies: reliability and validity of clinical and pathologic criteria. Neurology. 1996 Dec;47(6):1403–1409. doi: 10.1212/wnl.47.6.1403. [DOI] [PubMed] [Google Scholar]
  19. Perry R. H., Irving D., Blessed G., Fairbairn A., Perry E. K. Senile dementia of Lewy body type. A clinically and neuropathologically distinct form of Lewy body dementia in the elderly. J Neurol Sci. 1990 Feb;95(2):119–139. doi: 10.1016/0022-510x(90)90236-g. [DOI] [PubMed] [Google Scholar]
  20. Rocca W. A., Bonaiuto S., Lippi A., Luciani P., Turtù F., Cavarzeran F., Amaducci L. Prevalence of clinically diagnosed Alzheimer's disease and other dementing disorders: a door-to-door survey in Appignano, Macerata Province, Italy. Neurology. 1990 Apr;40(4):626–631. doi: 10.1212/wnl.40.4.626. [DOI] [PubMed] [Google Scholar]
  21. Stevens Tim, Livingston Gill, Kitchen Ginnette, Manela Monica, Walker Zuzana, Katona Cornelius. Islington study of dementia subtypes in the community. Br J Psychiatry. 2002 Mar;180:270–276. doi: 10.1192/bjp.180.3.270. [DOI] [PubMed] [Google Scholar]
  22. Sulkava R., Wikström J., Aromaa A., Raitasalo R., Lehtinen V., Lahtela K., Palo J. Prevalence of severe dementia in Finland. Neurology. 1985 Jul;35(7):1025–1029. doi: 10.1212/wnl.35.7.1025. [DOI] [PubMed] [Google Scholar]
  23. Sulkava Raimo. Differential diagnosis between early Parkinson's disease and dementia with Lewy bodies. Adv Neurol. 2003;91:411–413. [PubMed] [Google Scholar]
  24. Verghese J., Crystal H. A., Dickson D. W., Lipton R. B. Validity of clinical criteria for the diagnosis of dementia with Lewy bodies. Neurology. 1999 Dec 10;53(9):1974–1982. doi: 10.1212/wnl.53.9.1974. [DOI] [PubMed] [Google Scholar]
  25. Yamada T., Hattori H., Miura A., Tanabe M., Yamori Y. Prevalence of Alzheimer's disease, vascular dementia and dementia with Lewy bodies in a Japanese population. Psychiatry Clin Neurosci. 2001 Feb;55(1):21–25. doi: 10.1046/j.1440-1819.2001.00779.x. [DOI] [PubMed] [Google Scholar]
  26. Yamada Tatsuo, Kadekaru Hatsuko, Matsumoto Shoiku, Inada Hiromichi, Tanabe Mitunori, Moriguchi Emilio H., Moriguchi Yukio, Ishikawa Paulo, Ishikawa Alvina Goncalves, Taira Kazuhiko. Prevalence of dementia in the older Japanese-Brazilian population. Psychiatry Clin Neurosci. 2002 Feb;56(1):71–75. doi: 10.1046/j.1440-1819.2002.00931.x. [DOI] [PubMed] [Google Scholar]

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