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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 2003 Aug;74(8):1145–1147. doi: 10.1136/jnnp.74.8.1145

Spatial vision in visually asymptomatic subjects at high risk for multiple sclerosis

L Frisen
PMCID: PMC1738614  PMID: 12876258

Abstract

Methods: Fifteen subjects suffering a first neurological episode suggestive of multiple sclerosis in clinical presentation, immunological profile, and magnetic resonance imaging, were examined with a new, sensitive test of spatial vision, rarebit perimetry. None had symptoms or signs of optic neuropathy.

Results: Results of rarebit perimetry were significantly worse than those of 15 age matched normal controls (p=0.01); seven patients (47%) were outside normal limits. One patient only obtained abnormal results in high pass resolution perimetry.

Conclusions: Rarebit perimetry may help to close the sensitivity gap between clinical examinations and neuroimaging.

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