Abstract
This study demonstrates that CD8+ cytotoxic lymphocytes (CTL) are found in both primary and secondary syphilis lesions. CD8+ T cells were detected by immunohistology, and mRNAs for granzyme B and perforin were detected by reverse transcription and PCR, suggesting that CD8+ cytotoxic lymphocytes are activated.
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- Baker-Zander S. A., Lukehart S. A. Macrophage-mediated killing of opsonized Treponema pallidum. J Infect Dis. 1992 Jan;165(1):69–74. doi: 10.1093/infdis/165.1.69. [DOI] [PubMed] [Google Scholar]
- D'Andrea A., Rengaraju M., Valiante N. M., Chehimi J., Kubin M., Aste M., Chan S. H., Kobayashi M., Young D., Nickbarg E. Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med. 1992 Nov 1;176(5):1387–1398. doi: 10.1084/jem.176.5.1387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Engelkens H. J., ten Kate F. J., Judanarso J., Vuzevski V. D., van Lier J. B., Godschalk J. C., van der Sluis J. J., Stolz E. The localisation of treponemes and characterisation of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws. Genitourin Med. 1993 Apr;69(2):102–107. doi: 10.1136/sti.69.2.102. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harding C. V., Song R. Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules. J Immunol. 1994 Dec 1;153(11):4925–4933. [PubMed] [Google Scholar]
- Jenne D. E., Tschopp J. Granzymes, a family of serine proteases released from granules of cytolytic T lymphocytes upon T cell receptor stimulation. Immunol Rev. 1988 Mar;103:53–71. doi: 10.1111/j.1600-065x.1988.tb00749.x. [DOI] [PubMed] [Google Scholar]
- Kovacsovics-Bankowski M., Rock K. L. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science. 1995 Jan 13;267(5195):243–246. doi: 10.1126/science.7809629. [DOI] [PubMed] [Google Scholar]
- Lipman M. L., Stevens A. C., Strom T. B. Heightened intragraft CTL gene expression in acutely rejecting renal allografts. J Immunol. 1994 May 15;152(10):5120–5127. [PubMed] [Google Scholar]
- Liu C. C., Walsh C. M., Young J. D. Perforin: structure and function. Immunol Today. 1995 Apr;16(4):194–201. doi: 10.1016/0167-5699(95)80121-9. [DOI] [PubMed] [Google Scholar]
- Lukehart S. A., Baker-Zander S. A., Lloyd R. M., Sell S. Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions. J Immunol. 1980 Jan;124(1):461–467. [PubMed] [Google Scholar]
- Lukehart S. A., Baker-Zander S. A., Lloyd R. M., Sell S. Effect of cortisone administration on host-parasite relationships in early experimental syphilis. J Immunol. 1981 Oct;127(4):1361–1368. [PubMed] [Google Scholar]
- Sykes J. A., Miller J. N. Intracellular location of Treponema pallidum (Nichols strain) in the rabbit testis. Infect Immun. 1971 Sep;4(3):307–314. doi: 10.1128/iai.4.3.307-314.1971. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tosca A., Lehou J., Hatjivasiliou M., Varelzidis A., Stratigos J. D. Infiltrate of syphilitic lesions before and after treatment. Genitourin Med. 1988 Oct;64(5):289–293. doi: 10.1136/sti.64.5.289. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Van Voorhis W. C., Barrett L. K., Koelle D. M., Nasio J. M., Plummer F. A., Lukehart S. A. Primary and secondary syphilis lesions contain mRNA for Th1 cytokines. J Infect Dis. 1996 Feb;173(2):491–495. doi: 10.1093/infdis/173.2.491. [DOI] [PubMed] [Google Scholar]