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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 2004 Nov;75(11):1532–1540. doi: 10.1136/jnnp.2003.024968

The dynamic time course of memory recovery in transient global amnesia

B Guillery-Girard 1, B Desgranges 1, C Urban 1, P Piolino 1, V de la Sayette 1, F Eustache 1
PMCID: PMC1738827  PMID: 15489382

Abstract

Aims: To investigate the dynamic time course of transient global amnesia (TGA)—that is, the process of recovery and the interindividual variability—by testing four patients during the day of TGA itself (on three occasions) and at follow up (on two occasions).

Methods: A specially designed protocol focusing on semantic (both conceptual and autobiographical knowledge) and episodic (both anterograde and retrograde components) memory.

Results: Every patient showed marked impairment of both anterograde and retrograde episodic memory during the acute phase, with a relative preservation of personal and conceptual semantic knowledge. During the following phase, the authors observed similarities and differences among the patients' patterns of recovery. In general, retrograde amnesia recovered before the anterograde amnesia and anterograde episodic memory was recovered gradually in every case. In contrast, shrinkage of retrograde amnesia was more heterogeneous. In two of the patients, this shrinkage followed a chronological gradient and the most remote events were recovered first. In the two other patients, it depended more on the strength of the trace, and there was no temporal gradient. For the latter, an executive deficit could account for difficulties in accessing both conceptual knowledge and autobiographical memories.

Conclusions: This profile of recovery suggests a "neocortical to medial temporal" process in every case, and the possibility of an additional frontal dysfunction in some cases. Hence, the acute phase seems to be characterised by a common episodic impairment. This variability between subjects appears in the recovery phase with two different patterns of impairment.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baddeley A., Vargha-Khadem F., Mishkin M. Preserved recognition in a case of developmental amnesia: implications for the acquisition of semantic memory? J Cogn Neurosci. 2001 Apr 1;13(3):357–369. doi: 10.1162/08989290151137403. [DOI] [PubMed] [Google Scholar]
  2. Baron J. C., Petit-Taboué M. C., Le Doze F., Desgranges B., Ravenel N., Marchal G. Right frontal cortex hypometabolism in transient global amnesia. A PET study. Brain. 1994 Jun;117(Pt 3):545–552. doi: 10.1093/brain/117.3.545. [DOI] [PubMed] [Google Scholar]
  3. Cardebat D., Doyon B., Puel M., Goulet P., Joanette Y. Evocation lexicale formelle et sémantique chez des sujets normaux. Performances et dynamiques de production en fonction du sexe, de l'âge et du niveau d'étude. Acta Neurol Belg. 1990;90(4):207–217. [PubMed] [Google Scholar]
  4. Cermak L. S., O'Connor M. The anterograde and retrograde retrieval ability of a patient with amnesia due to encephalitis. Neuropsychologia. 1983;21(3):213–234. doi: 10.1016/0028-3932(83)90039-8. [DOI] [PubMed] [Google Scholar]
  5. Davidson Patrick S. R., Glisky Elizabeth L. Is flashbulb memory a special instance of source memory? Evidence from older adults. Memory. 2002 Mar;10(2):99–111. doi: 10.1080/09658210143000227. [DOI] [PubMed] [Google Scholar]
  6. Dritschel B. H., Williams J. M., Baddeley A. D., Nimmo-Smith I. Autobiographical fluency: a method for the study of personal memory. Mem Cognit. 1992 Mar;20(2):133–140. doi: 10.3758/bf03197162. [DOI] [PubMed] [Google Scholar]
  7. Duncan R., Patterson J., Roberts R., Hadley D. M., Bone I. Ictal/postictal SPECT in the pre-surgical localisation of complex partial seizures. J Neurol Neurosurg Psychiatry. 1993 Feb;56(2):141–148. doi: 10.1136/jnnp.56.2.141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Eustache F., Desgranges B., Laville P., Guillery B., Lalevée C., Schaeffer S., de la Sayette V., Iglesias S., Baron J. C., Viader F. Episodic memory in transient global amnesia: encoding, storage, or retrieval deficit? J Neurol Neurosurg Psychiatry. 1999 Feb;66(2):148–154. doi: 10.1136/jnnp.66.2.148. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Eustache F., Desgranges B., Petit-Taboué M. C., de la Sayette V., Piot V., Sablé C., Marchal G., Baron J. C. Transient global amnesia: implicit/explicit memory dissociation and PET assessment of brain perfusion and oxygen metabolism in the acute stage. J Neurol Neurosurg Psychiatry. 1997 Sep;63(3):357–367. doi: 10.1136/jnnp.63.3.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Evans J., Wilson B., Wraight E. P., Hodges J. R. Neuropsychological and SPECT scan findings during and after transient global amnesia: evidence for the differential impairment of remote episodic memory. J Neurol Neurosurg Psychiatry. 1993 Nov;56(11):1227–1230. doi: 10.1136/jnnp.56.11.1227. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gardiner J. M., Ramponi C., Richardson-Klavehn A. Experiences of remembering, knowing, and guessing. Conscious Cogn. 1998 Mar;7(1):1–26. doi: 10.1006/ccog.1997.0321. [DOI] [PubMed] [Google Scholar]
  12. Greene J. D., Hodges J. R., Baddeley A. D. Autobiographical memory and executive function in early dementia of Alzheimer type. Neuropsychologia. 1995 Dec;33(12):1647–1670. doi: 10.1016/0028-3932(95)00046-1. [DOI] [PubMed] [Google Scholar]
  13. Guillery B., Desgranges B., Katis S., de la Sayette V., Viader F., Eustache F. Semantic acquisition without memories: evidence from transient global amnesia. Neuroreport. 2001 Dec 4;12(17):3865–3869. doi: 10.1097/00001756-200112040-00052. [DOI] [PubMed] [Google Scholar]
  14. Hodges J. R., McCarthy R. A. Loss of remote memory: a cognitive neuropsychological perspective. Curr Opin Neurobiol. 1995 Apr;5(2):178–183. doi: 10.1016/0959-4388(95)80024-7. [DOI] [PubMed] [Google Scholar]
  15. Hodges J. R. Semantic memory and frontal executive function during transient global amnesia. J Neurol Neurosurg Psychiatry. 1994 May;57(5):605–608. doi: 10.1136/jnnp.57.5.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Hodges J. R., Ward C. D. Observations during transient global amnesia. A behavioural and neuropsychological study of five cases. Brain. 1989 Jun;112(Pt 3):595–620. doi: 10.1093/brain/112.3.595. [DOI] [PubMed] [Google Scholar]
  17. Hodges J. R., Warlow C. P. Syndromes of transient amnesia: towards a classification. A study of 153 cases. J Neurol Neurosurg Psychiatry. 1990 Oct;53(10):834–843. doi: 10.1136/jnnp.53.10.834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kapur N., Abbott P., Footitt D., Millar J. Long-term perceptual priming in transient global amnesia. Brain Cogn. 1996 Jun;31(1):63–74. doi: 10.1006/brcg.1996.0025. [DOI] [PubMed] [Google Scholar]
  19. Kapur N., Millar J., Abbott P., Carter M. Recovery of function processes in human amnesia: evidence from transient global amnesia. Neuropsychologia. 1998 Jan;36(1):99–107. doi: 10.1016/s0028-3932(97)00096-1. [DOI] [PubMed] [Google Scholar]
  20. Kapur Narinder, Logie Robert. Unravelling the cognitive architecture of transient global amnesia. Brain. 2003 Sep;126(Pt 9):1915–1916. doi: 10.1093/brain/awg256. [DOI] [PubMed] [Google Scholar]
  21. Kopelman M. D., Kapur N. The loss of episodic memories in retrograde amnesia: single-case and group studies. Philos Trans R Soc Lond B Biol Sci. 2001 Sep 29;356(1413):1409–1421. doi: 10.1098/rstb.2001.0942. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Kopelman M. D., Stanhope N., Kingsley D. Temporal and spatial context memory in patients with focal frontal, temporal lobe, and diencephalic lesions. Neuropsychologia. 1997 Dec;35(12):1533–1545. doi: 10.1016/s0028-3932(97)00076-6. [DOI] [PubMed] [Google Scholar]
  23. Kritchevsky M., Squire L. R. Transient global amnesia: evidence for extensive, temporally graded retrograde amnesia. Neurology. 1989 Feb;39(2 Pt 1):213–218. doi: 10.1212/wnl.39.2.213. [DOI] [PubMed] [Google Scholar]
  24. Lin K. N., Liu R. S., Yeh T. P., Wang S. J., Liu H. C. Posterior ischemia during an attack of transient global amnesia. Stroke. 1993 Jul;24(7):1093–1095. doi: 10.1161/01.str.24.7.1093. [DOI] [PubMed] [Google Scholar]
  25. Maguire E. A., Vargha-Khadem F., Mishkin M. The effects of bilateral hippocampal damage on fMRI regional activations and interactions during memory retrieval. Brain. 2001 Jun;124(Pt 6):1156–1170. doi: 10.1093/brain/124.6.1156. [DOI] [PubMed] [Google Scholar]
  26. Marsh Richard L., Hicks Jason L., Hancock Thomas W., Munsayac Kirk. Investigating the output monitoring component of event-based prospective memory performance. Mem Cognit. 2002 Mar;30(2):302–311. doi: 10.3758/bf03195291. [DOI] [PubMed] [Google Scholar]
  27. Mayr Ulrich. On the dissociation between clustering and switching in verbal fluency: comment on Troyer, Moscovitch, Winocur, Alexander and Stuss. Neuropsychologia. 2002;40(5):562–566. doi: 10.1016/s0028-3932(01)00132-4. [DOI] [PubMed] [Google Scholar]
  28. Nadel L., Moscovitch M. Memory consolidation, retrograde amnesia and the hippocampal complex. Curr Opin Neurobiol. 1997 Apr;7(2):217–227. doi: 10.1016/s0959-4388(97)80010-4. [DOI] [PubMed] [Google Scholar]
  29. Piolino Pascale, Desgranges Béatrice, Belliard Serge, Matuszewski Vanessa, Lalevée Catherine, De la Sayette Vincent, Eustache Francis. Autobiographical memory and autonoetic consciousness: triple dissociation in neurodegenerative diseases. Brain. 2003 Jun 23;126(Pt 10):2203–2219. doi: 10.1093/brain/awg222. [DOI] [PubMed] [Google Scholar]
  30. Quinette Peggy, Guillery Bérengère, Desgranges Béatrice, de la Sayette Vincent, Viader Fausto, Eustache Francis. Working memory and executive functions in transient global amnesia. Brain. 2003 Jul 22;126(Pt 9):1917–1934. doi: 10.1093/brain/awg201. [DOI] [PubMed] [Google Scholar]
  31. Regard M., Landis T. Transient global amnesia: neuropsychological dysfunction during attack and recovery in two "pure" cases. J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):668–672. doi: 10.1136/jnnp.47.7.668. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Rosenbaum R. S., Winocur G., Moscovitch M. New views on old memories: re-evaluating the role of the hippocampal complex. Behav Brain Res. 2001 Dec 14;127(1-2):183–197. doi: 10.1016/s0166-4328(01)00363-1. [DOI] [PubMed] [Google Scholar]
  33. Stillhard G., Landis T., Schiess R., Regard M., Sialer G. Bitemporal hypoperfusion in transient global amnesia: 99m-Tc-HM-PAO SPECT and neuropsychological findings during and after an attack. J Neurol Neurosurg Psychiatry. 1990 Apr;53(4):339–342. doi: 10.1136/jnnp.53.4.339. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Takeuchi R., Yonekura Y., Matsuda H., Nishimura Y., Tanaka H., Ohta H., Sakahara H., Konishi J. Resting and acetazolamide-challenged technetium-99m-ECD SPECT in transient global amnesia. J Nucl Med. 1998 Aug;39(8):1360–1362. [PubMed] [Google Scholar]
  35. Troyer A. K., Moscovitch M., Winocur G., Alexander M. P., Stuss D. Clustering and switching on verbal fluency: the effects of focal frontal- and temporal-lobe lesions. Neuropsychologia. 1998 Jun;36(6):499–504. doi: 10.1016/s0028-3932(97)00152-8. [DOI] [PubMed] [Google Scholar]
  36. Tulving E. Episodic memory and common sense: how far apart? Philos Trans R Soc Lond B Biol Sci. 2001 Sep 29;356(1413):1505–1515. doi: 10.1098/rstb.2001.0937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Tulving E. Episodic memory and common sense: how far apart? Philos Trans R Soc Lond B Biol Sci. 2001 Sep 29;356(1413):1505–1515. doi: 10.1098/rstb.2001.0937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Tulving E., Schacter D. L., McLachlan D. R., Moscovitch M. Priming of semantic autobiographical knowledge: a case study of retrograde amnesia. Brain Cogn. 1988 Aug;8(1):3–20. doi: 10.1016/0278-2626(88)90035-8. [DOI] [PubMed] [Google Scholar]
  39. Warren J. D., Chatterton B., Thompson P. D. A SPECT study of the anatomy of transient global amnesia. J Clin Neurosci. 2000 Jan;7(1):57–59. doi: 10.1054/jocn.1998.0129. [DOI] [PubMed] [Google Scholar]

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