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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 2004 Jun;75(6):889–892. doi: 10.1136/jnnp.2003.012781

Correlation between clinical characteristics and proliferative activity in patients with craniopharyngioma

M Losa 1, A Vimercati 1, S Acerno 1, R Barzaghi 1, P Mortini 1, F Mangili 1, M Terreni 1, G Santambrogio 1, M Giovanelli 1
PMCID: PMC1739047  PMID: 15146007

Abstract

Objectives: The aim of the study was to correlate the Ki-67 and cyclin A labelling index (LI) with clinical characteristics and risk of recurrence of craniopharyngiomas.

Methods: 47 consecutive patients were studied, 21 female and 26 male, aged 34.3 (2.8) years. Immunohistochemical analysis was performed on paraffin wax embedded material using monoclonal antibodies directed against the proliferation associated nuclear antigen Ki-67 and cyclin A.

Results: The median Ki-67 LI was 8.6% (interquartile range, 4.4%–14.0%). Ki-67 LI was significantly higher in tumours with a heavy inflammatory reaction and diabetes insipidus at presentation, whereas other clinical and histological features were not associated with the proliferation index. There was a strong linear correlation between Ki-67 LI and cyclin A LI (r = 0.77; p<0.0001); therefore, cyclin A LI showed the same clinical and histological relations described for Ki-67 LI. Recurrence of craniopharyngioma occurred in 13 of 46 patients (28.3%). The median Ki-67 LI in the 13 recurrent craniopharyngiomas (9.0%) was not significantly different from that of non-recurring tumours (7.9%). Cyclin A LI was also not associated with the risk of relapse.

Conclusions: This study confirms the great variability of proliferative activity in craniopharyngiomas. Ki-67 and cyclin A LIs were associated with the presence of a heavy inflammatory reaction and diabetes insipidus, but did not correlate with the long term risk of tumour regrowth.

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Selected References

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  1. Adamson T. E., Wiestler O. D., Kleihues P., Yaşargil M. G. Correlation of clinical and pathological features in surgically treated craniopharyngiomas. J Neurosurg. 1990 Jul;73(1):12–17. doi: 10.3171/jns.1990.73.1.0012. [DOI] [PubMed] [Google Scholar]
  2. Bunin G. R., Surawicz T. S., Witman P. A., Preston-Martin S., Davis F., Bruner J. M. The descriptive epidemiology of craniopharyngioma. J Neurosurg. 1998 Oct;89(4):547–551. doi: 10.3171/jns.1998.89.4.0547. [DOI] [PubMed] [Google Scholar]
  3. Carmel P. W., Antunes J. L., Chang C. H. Craniopharyngiomas in children. Neurosurgery. 1982 Sep;11(3):382–389. doi: 10.1227/00006123-198209000-00008. [DOI] [PubMed] [Google Scholar]
  4. Crotty T. B., Scheithauer B. W., Young W. F., Jr, Davis D. H., Shaw E. G., Miller G. M., Burger P. C. Papillary craniopharyngioma: a clinicopathological study of 48 cases. J Neurosurg. 1995 Aug;83(2):206–214. doi: 10.3171/jns.1995.83.2.0206. [DOI] [PubMed] [Google Scholar]
  5. Desdouets C., Sobczak-Thépot J., Murphy M., Bréchot C. Cyclin A: function and expression during cell proliferation. Prog Cell Cycle Res. 1995;1:115–123. doi: 10.1007/978-1-4615-1809-9_9. [DOI] [PubMed] [Google Scholar]
  6. Duff J., Meyer F. B., Ilstrup D. M., Laws E. R., Jr, Schleck C. D., Scheithauer B. W. Long-term outcomes for surgically resected craniopharyngiomas. Neurosurgery. 2000 Feb;46(2):291–305. doi: 10.1097/00006123-200002000-00007. [DOI] [PubMed] [Google Scholar]
  7. Eldevik O. P., Blaivas M., Gabrielsen T. O., Hald J. K., Chandler W. F. Craniopharyngioma: radiologic and histologic findings and recurrence. AJNR Am J Neuroradiol. 1996 Sep;17(8):1427–1439. [PMC free article] [PubMed] [Google Scholar]
  8. Fahlbusch R., Honegger J., Paulus W., Huk W., Buchfelder M. Surgical treatment of craniopharyngiomas: experience with 168 patients. J Neurosurg. 1999 Feb;90(2):237–250. doi: 10.3171/jns.1999.90.2.0237. [DOI] [PubMed] [Google Scholar]
  9. Fischer E. G., Welch K., Shillito J., Jr, Winston K. R., Tarbell N. J. Craniopharyngiomas in children. Long-term effects of conservative surgical procedures combined with radiation therapy. J Neurosurg. 1990 Oct;73(4):534–540. doi: 10.3171/jns.1990.73.4.0534. [DOI] [PubMed] [Google Scholar]
  10. Hall P. A., Woods A. L. Immunohistochemical markers of cellular proliferation: achievements, problems and prospects. Cell Tissue Kinet. 1990 Nov;23(6):505–522. doi: 10.1111/j.1365-2184.1990.tb01343.x. [DOI] [PubMed] [Google Scholar]
  11. Kim S. K., Wang K. C., Shin S. H., Choe G., Chi J. G., Cho B. K. Radical excision of pediatric craniopharyngioma: recurrence pattern and prognostic factors. Childs Nerv Syst. 2001 Sep;17(9):531–537. doi: 10.1007/s003810100458. [DOI] [PubMed] [Google Scholar]
  12. Losa M., Barzaghi R. L., Mortini P., Franzin A., Mangili F., Terreni M. R., Giovanelli M. Determination of the proliferation and apoptotic index in adrenocorticotropin-secreting pituitary tumors : comparison between micro- and macroadenomas. Am J Pathol. 2000 Jan;156(1):245–251. doi: 10.1016/S0002-9440(10)64725-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Losa M., Ciccarelli E., Mortini P., Barzaghi R., Gaia D., Faccani G., Papotti M., Mangili F., Terreni M. R., Camanni F. Effects of octreotide treatment on the proliferation and apoptotic index of GH-secreting pituitary adenomas. J Clin Endocrinol Metab. 2001 Nov;86(11):5194–5200. doi: 10.1210/jcem.86.11.7986. [DOI] [PubMed] [Google Scholar]
  14. Losa M., Franzin A., Mangili F., Terreni M. R., Barzaghi R., Veglia F., Mortini P., Giovanelli M. Proliferation index of nonfunctioning pituitary adenomas: correlations with clinical characteristics and long-term follow-up results. Neurosurgery. 2000 Dec;47(6):1313–1319. [PubMed] [Google Scholar]
  15. Losa M., Franzin A., Mortini P., Terreni M. R., Mangili F., Giovanelli M. Usefulness of markers of cell proliferation in the management of pituitary adenomas. Clin Sci (Lond) 1998 Aug;95(2):129–135. [PubMed] [Google Scholar]
  16. MacCallum D. E., Hall P. A. The location of pKi67 in the outer dense fibrillary compartment of the nucleolus points to a role in ribosome biogenesis during the cell division cycle. J Pathol. 2000 Apr;190(5):537–544. doi: 10.1002/(SICI)1096-9896(200004)190:5<537::AID-PATH577>3.0.CO;2-W. [DOI] [PubMed] [Google Scholar]
  17. Nishi T., Kuratsu J., Takeshima H., Saito Y., Kochi M., Ushio Y. Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma. Int J Mol Med. 1999 Feb;3(2):157–161. [PubMed] [Google Scholar]
  18. Prosperi E., Stivala L. A., Scovassi A. I., Bianchi L. Cyclins: relevance of subcellular localization in cell cycle control. Eur J Histochem. 1997;41(3):161–168. [PubMed] [Google Scholar]
  19. Raghavan R., Dickey W. T., Jr, Margraf L. R., White C. L., 3rd, Coimbra C., Hynan L. S., Rushing E. J. Proliferative activity in craniopharyngiomas: clinicopathological correlations in adults and children. Surg Neurol. 2000 Sep;54(3):241–248. doi: 10.1016/s0090-3019(00)00298-6. [DOI] [PubMed] [Google Scholar]
  20. Scholzen T., Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol. 2000 Mar;182(3):311–322. doi: 10.1002/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9. [DOI] [PubMed] [Google Scholar]
  21. Slootweg P. J. p53 protein and Ki-67 reactivity in epithelial odontogenic lesions. An immunohistochemical study. J Oral Pathol Med. 1995 Oct;24(9):393–397. doi: 10.1111/j.1600-0714.1995.tb01207.x. [DOI] [PubMed] [Google Scholar]
  22. Stahnke N., Grubel G., Lagenstein I., Willig R. P. Long-term follow-up of children with craniopharyngioma. Eur J Pediatr. 1984 Aug;142(3):179–185. doi: 10.1007/BF00442445. [DOI] [PubMed] [Google Scholar]
  23. Szeifert G. T., Sipos L., Horváth M., Sarker M. H., Major O., Salomváry B., Czirják S., Bálint K., Slowik F., Kolonics L. Pathological characteristics of surgically removed craniopharyngiomas: analysis of 131 cases. Acta Neurochir (Wien) 1993;124(2-4):139–143. doi: 10.1007/BF01401137. [DOI] [PubMed] [Google Scholar]
  24. Villani R. M., Tomei G., Bello L., Sganzerla E., Ambrosi B., Re T., Giovanelli Barilari M. Long-term results of treatment for craniopharyngioma in children. Childs Nerv Syst. 1997 Jul;13(7):397–405. doi: 10.1007/s003810050108. [DOI] [PubMed] [Google Scholar]
  25. Weiner H. L., Wisoff J. H., Rosenberg M. E., Kupersmith M. J., Cohen H., Zagzag D., Shiminski-Maher T., Flamm E. S., Epstein F. J., Miller D. C. Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery. 1994 Dec;35(6):1001–1011. doi: 10.1227/00006123-199412000-00001. [DOI] [PubMed] [Google Scholar]
  26. Yaşargil M. G., Curcic M., Kis M., Siegenthaler G., Teddy P. J., Roth P. Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg. 1990 Jul;73(1):3–11. doi: 10.3171/jns.1990.73.1.0003. [DOI] [PubMed] [Google Scholar]

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