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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 2005 Nov;76(11):1501–1505. doi: 10.1136/jnnp.2004.051268

Planning and realisation of complex intentions in patients with Parkinson's disease

M Kliegel 1, L Phillips 1, U Lemke 1, U Kopp 1
PMCID: PMC1739411  PMID: 16227539

Abstract

Background: There is some evidence that patients with Parkinson's disease may impaired in prospective memory performance (planning and self initiated realisation of delayed intentions). Little is known about the effect of the disease on distinct phases of prospective memory and the potential mechanisms underlying these effects.

Objective: To investigate intention formation, intention retention, intention initiation, and intention execution of patients with Parkinson's disease and test for the mediating influence of working memory, inhibition, short term retrospective memory, and divided attention.

Methods: 16 patients with Parkinson's disease and 16 age and education matched normal controls were given a complex event based prospective memory task which differentiates four phases of prospective remembering. In addition, participants completed tasks assessing potential cognitive mediators.

Results: On the prospective remembering task, Parkinson patients were impaired in the intention formation phase and showed a trend towards impairment in the intention initiation. In contrast, there were no impairments of retrospective intention retention or the fidelity with which the patients executed their previously developed plan. The group effects were related to interindividual differences in working memory span.

Conclusions: The results suggest that the planning phase of prospective remembering is specifically impaired in Parkinson's disease, and that the impairment is related to working memory deficit. In contrast, even when complex intentions have to be remembered, the retrospective storage of intentions to be performed is not impaired.

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Selected References

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  1. Bradley V. A., Welch J. L., Dick D. J. Visuospatial working memory in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1989 Nov;52(11):1228–1235. doi: 10.1136/jnnp.52.11.1228. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Breen E. K. Recall and recognition memory in Parkinson's disease. Cortex. 1993 Mar;29(1):91–102. doi: 10.1016/s0010-9452(13)80214-6. [DOI] [PubMed] [Google Scholar]
  3. Brunfaut E., Vanoverberghe V., d'Ydewalle G. Prospective remembering of Korsakoffs and alcoholics as a function of the prospective-memory and on-going tasks. Neuropsychologia. 2000;38(7):975–984. doi: 10.1016/s0028-3932(00)00016-6. [DOI] [PubMed] [Google Scholar]
  4. Defer G. L., Widner H., Marié R. M., Rémy P., Levivier M. Core assessment program for surgical interventional therapies in Parkinson's disease (CAPSIT-PD). Mov Disord. 1999 Jul;14(4):572–584. doi: 10.1002/1531-8257(199907)14:4<572::aid-mds1005>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  5. Dubois B., Pillon B. Cognitive deficits in Parkinson's disease. J Neurol. 1997 Jan;244(1):2–8. doi: 10.1007/pl00007725. [DOI] [PubMed] [Google Scholar]
  6. Fern-Pollak Liory, Whone Alan L., Brooks David J., Mehta Mitul A. Cognitive and motor effects of dopaminergic medication withdrawal in Parkinson's disease. Neuropsychologia. 2004;42(14):1917–1926. doi: 10.1016/j.neuropsychologia.2004.05.004. [DOI] [PubMed] [Google Scholar]
  7. Houx P. J., Jolles J., Vreeling F. W. Stroop interference: aging effects assessed with the Stroop Color-Word Test. Exp Aging Res. 1993 Jul-Sep;19(3):209–224. doi: 10.1080/03610739308253934. [DOI] [PubMed] [Google Scholar]
  8. Huppert F. A., Beardsall L. Prospective memory impairment as an early indicator of dementia. J Clin Exp Neuropsychol. 1993 Sep;15(5):805–821. doi: 10.1080/01688639308402597. [DOI] [PubMed] [Google Scholar]
  9. Katai S., Maruyama T., Hashimoto T., Ikeda S. Event based and time based prospective memory in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2003 Jun;74(6):704–709. doi: 10.1136/jnnp.74.6.704. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Kliegel M., McDaniel M. A., Einstein G. O. Plan formation, retention, and execution in prospective memory: a new approach and age-related effects. Mem Cognit. 2000 Sep;28(6):1041–1049. doi: 10.3758/bf03209352. [DOI] [PubMed] [Google Scholar]
  11. Kliegel Matthias, Eschen Anne, Thöne-Otto Angelika I. T. Planning and realization of complex intentions in traumatic brain injury and normal aging. Brain Cogn. 2004 Oct;56(1):43–54. doi: 10.1016/j.bandc.2004.05.005. [DOI] [PubMed] [Google Scholar]
  12. Meissner F., Hacker W., Heilemann H. Gedächtnisleistungen und Instruktionseffekte bei Schizophrenie. Eine vergleichende Untersuchung an chronish Schizophrenen und Gesunden. Psychiatr Prax. 2001 May;28(4):180–188. doi: 10.1055/s-2001-13266. [DOI] [PubMed] [Google Scholar]
  13. Morris R. G., Downes J. J., Sahakian B. J., Evenden J. L., Heald A., Robbins T. W. Planning and spatial working memory in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):757–766. doi: 10.1136/jnnp.51.6.757. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Owen A. M., James M., Leigh P. N., Summers B. A., Marsden C. D., Quinn N. P., Lange K. W., Robbins T. W. Fronto-striatal cognitive deficits at different stages of Parkinson's disease. Brain. 1992 Dec;115(Pt 6):1727–1751. doi: 10.1093/brain/115.6.1727. [DOI] [PubMed] [Google Scholar]
  15. Pastor M. A., Artieda J., Jahanshahi M., Obeso J. A. Time estimation and reproduction is abnormal in Parkinson's disease. Brain. 1992 Feb;115(Pt 1):211–225. doi: 10.1093/brain/115.1.211. [DOI] [PubMed] [Google Scholar]
  16. Sgaramella T. M., Borgo F., Fenzo F., Garofalo P., Toso V. Memory for/and execution of future intentions: evidence from patients with Herpes Simplex Encephalitis. Brain Cogn. 2000 Jun-Aug;43(1-3):388–392. [PubMed] [Google Scholar]
  17. Shallice T., Burgess P. W. Deficits in strategy application following frontal lobe damage in man. Brain. 1991 Apr;114(Pt 2):727–741. doi: 10.1093/brain/114.2.727. [DOI] [PubMed] [Google Scholar]
  18. Smith E. E., Jonides J. Storage and executive processes in the frontal lobes. Science. 1999 Mar 12;283(5408):1657–1661. doi: 10.1126/science.283.5408.1657. [DOI] [PubMed] [Google Scholar]

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