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Journal of Neurology, Neurosurgery, and Psychiatry logoLink to Journal of Neurology, Neurosurgery, and Psychiatry
. 2005 Dec;76(12):1736–1738. doi: 10.1136/jnnp.2005.065359

Ambiguous value of Haemophilus influenzae isolation in Guillain-Barré and Fisher syndromes

M Koga 1, S Koike 1, K Hirata 1, N Yuki 1
PMCID: PMC1739435  PMID: 16291907

Abstract

Objective: To determine whether isolation of H influenzae indicates it is a causative agent in GBS and Fisher syndrome.

Results: Four (15%) of 27 patients with GBS and Fisher syndrome in whom H influenzae was isolated were also seropositive for Campylobacter jejuni. Antiganglioside IgG antibodies in these four patients did not cross react with their H influenzae lipo-oligosaccharides, whereas antiganglioside antibodies in the four patients with positive serology for H influenzae did.

Conclusions: The findings suggest that H influenzae isolation is not always indicative of the causative agent in these syndromes and that tests for other infections should be made, even in cases of positive culture.

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