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. 1996 Apr;64(4):1488–1490. doi: 10.1128/iai.64.4.1488-1490.1996

Reactivation of Chlamydia pneumoniae infection in mice by cortisone treatment.

K Laitinen 1, A L Laurila 1, M Leinonen 1, P Saikku 1
PMCID: PMC173951  PMID: 8606126

Abstract

Reactivation of Chlamydia pneumoniae infection was studied by inducing immunosuppression by cortisone acetate treatment given every other day for 14 days in intranasally infected NIH/s mice. The treatment started 2 or 4 weeks after primary infection, when no C. pneumoniae was detected. C. pneumoniae could be recovered from the lung cultures on days 7 and 9 in 10 and 60% of the mice, respectively, when cortisone treatment was begun 30 days after infection. These results confirm the persistent nature of C. pneumoniae infection.

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Selected References

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