Abstract
Objective: To report two cases of fatal toxin associated leukoencephalopathy, along with detailed imaging and neuropathological studies.
Results: MRI revealed diffuse white matter changes. Histologically there was widespread confluent vacuolar degeneration of the deep white matter. In both cases, there was sparing of the brain stem and cerebellar white matter. There was evidence of severe and extensive axonal injury.
Conclusions: This pattern of radiological involvement and histological findings has not previously been reported and may reflect the presence of a yet unidentified impurity.
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