Abstract
The adherence characteristics in vivo and virulence of two isogenic strains of Staphylococcus aureus differing in fibronectin binding were compared in a rat model of catheter-induced infective endocarditis. No differences were found between the two strains. The results strongly point to the multifactorial nature of bacterial adherence to damaged heart valves and suggest that other binding functions can compensate for the lack of fibronectin binding in S. aureus.
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- Bodén M. K., Flock J. I. Evidence for three different fibrinogen-binding proteins with unique properties from Staphylococcus aureus strain Newman. Microb Pathog. 1992 Apr;12(4):289–298. doi: 10.1016/0882-4010(92)90047-r. [DOI] [PubMed] [Google Scholar]
- Buxton T. B., Rissing J. P., Horner J. A., Plowman K. M., Scott D. F., Sprinkle T. J., Best G. K. Binding of a Staphylococcus aureus bone pathogen to type I collagen. Microb Pathog. 1990 Jun;8(6):441–448. doi: 10.1016/0882-4010(90)90031-k. [DOI] [PubMed] [Google Scholar]
- Chhatwal G. S., Preissner K. T., Müller-Berghaus G., Blobel H. Specific binding of the human S protein (vitronectin) to streptococci, Staphylococcus aureus, and Escherichia coli. Infect Immun. 1987 Aug;55(8):1878–1883. doi: 10.1128/iai.55.8.1878-1883.1987. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Durack D. T., Beeson P. B. Experimental bacterial endocarditis. I. Colonization of a sterile vegetation. Br J Exp Pathol. 1972 Feb;53(1):44–49. [PMC free article] [PubMed] [Google Scholar]
- Flock J. I., Fröman G., Jönsson K., Guss B., Signäs C., Nilsson B., Raucci G., Hök M., Wadström T., Lindberg M. Cloning and expression of the gene for a fibronectin-binding protein from Staphylococcus aureus. EMBO J. 1987 Aug;6(8):2351–2357. doi: 10.1002/j.1460-2075.1987.tb02511.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greene C., McDevitt D., Francois P., Vaudaux P. E., Lew D. P., Foster T. J. Adhesion properties of mutants of Staphylococcus aureus defective in fibronectin-binding proteins and studies on the expression of fnb genes. Mol Microbiol. 1995 Sep;17(6):1143–1152. doi: 10.1111/j.1365-2958.1995.mmi_17061143.x. [DOI] [PubMed] [Google Scholar]
- Herrmann M., Suchard S. J., Boxer L. A., Waldvogel F. A., Lew P. D. Thrombospondin binds to Staphylococcus aureus and promotes staphylococcal adherence to surfaces. Infect Immun. 1991 Jan;59(1):279–288. doi: 10.1128/iai.59.1.279-288.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Héraïef E., Glauser M. P., Freedman L. R. Natural history of aortic valve endocarditis in rats. Infect Immun. 1982 Jul;37(1):127–131. doi: 10.1128/iai.37.1.127-131.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jönsson K., Signäs C., Müller H. P., Lindberg M. Two different genes encode fibronectin binding proteins in Staphylococcus aureus. The complete nucleotide sequence and characterization of the second gene. Eur J Biochem. 1991 Dec 18;202(3):1041–1048. doi: 10.1111/j.1432-1033.1991.tb16468.x. [DOI] [PubMed] [Google Scholar]
- Kuusela P. Fibronectin binds to Staphylococcus aureus. Nature. 1978 Dec 14;276(5689):718–720. doi: 10.1038/276718a0. [DOI] [PubMed] [Google Scholar]
- Kuypers J. M., Proctor R. A. Reduced adherence to traumatized rat heart valves by a low-fibronectin-binding mutant of Staphylococcus aureus. Infect Immun. 1989 Aug;57(8):2306–2312. doi: 10.1128/iai.57.8.2306-2312.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Liang O. D., Flock J. I., Wadström T. Evidence that the heparin-binding consensus sequence of vitronectin is recognized by Staphylococcus aureus. J Biochem. 1994 Aug;116(2):457–463. doi: 10.1093/oxfordjournals.jbchem.a124546. [DOI] [PubMed] [Google Scholar]
- McDevitt D., Vaudaux P., Foster T. J. Genetic evidence that bound coagulase of Staphylococcus aureus is not clumping factor. Infect Immun. 1992 Apr;60(4):1514–1523. doi: 10.1128/iai.60.4.1514-1523.1992. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moreillon P., Entenza J. M., Francioli P., McDevitt D., Foster T. J., François P., Vaudaux P. Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditis. Infect Immun. 1995 Dec;63(12):4738–4743. doi: 10.1128/iai.63.12.4738-4743.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Park P. W., Roberts D. D., Grosso L. E., Parks W. C., Rosenbloom J., Abrams W. R., Mecham R. P. Binding of elastin to Staphylococcus aureus. J Biol Chem. 1991 Dec 5;266(34):23399–23406. [PubMed] [Google Scholar]
- Patti J. M., Boles J. O., Hök M. Identification and biochemical characterization of the ligand binding domain of the collagen adhesin from Staphylococcus aureus. Biochemistry. 1993 Oct 26;32(42):11428–11435. doi: 10.1021/bi00093a021. [DOI] [PubMed] [Google Scholar]
- Scheld W. M., Strunk R. W., Balian G., Calderone R. A. Microbial adhesion to fibronectin in vitro correlates with production of endocarditis in rabbits. Proc Soc Exp Biol Med. 1985 Dec;180(3):474–482. doi: 10.3181/00379727-180-42205. [DOI] [PubMed] [Google Scholar]
- Schennings T., Heimdahl A., Coster K., Flock J. I. Immunization with fibronectin binding protein from Staphylococcus aureus protects against experimental endocarditis in rats. Microb Pathog. 1993 Sep;15(3):227–236. doi: 10.1006/mpat.1993.1073. [DOI] [PubMed] [Google Scholar]
- Signäs C., Raucci G., Jönsson K., Lindgren P. E., Anantharamaiah G. M., Hök M., Lindberg M. Nucleotide sequence of the gene for a fibronectin-binding protein from Staphylococcus aureus: use of this peptide sequence in the synthesis of biologically active peptides. Proc Natl Acad Sci U S A. 1989 Jan;86(2):699–703. doi: 10.1073/pnas.86.2.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vaudaux P. E., François P., Proctor R. A., McDevitt D., Foster T. J., Albrecht R. M., Lew D. P., Wabers H., Cooper S. L. Use of adhesion-defective mutants of Staphylococcus aureus to define the role of specific plasma proteins in promoting bacterial adhesion to canine arteriovenous shunts. Infect Immun. 1995 Feb;63(2):585–590. doi: 10.1128/iai.63.2.585-590.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vercellotti G. M., McCarthy J. B., Lindholm P., Peterson P. K., Jacob H. S., Furcht L. T. Extracellular matrix proteins (fibronectin, laminin, and type IV collagen) bind and aggregate bacteria. Am J Pathol. 1985 Jul;120(1):13–21. [PMC free article] [PubMed] [Google Scholar]
- Vlodavsky I., Eldor A., HyAm E., Atzom R., Fuks Z. Platelet interaction with the extracellular matrix produced by cultured endothelial cells: a model to study the thrombogenicity of isolated subendothelial basal lamina. Thromb Res. 1982 Oct 15;28(2):179–191. doi: 10.1016/0049-3848(82)90260-2. [DOI] [PubMed] [Google Scholar]