Stimulation of IL-8 release from epithelial cells by gas cooker PM₁₀: a pilot study

Abstract

OBJECTIVE—To measure the effect of matter collected by a method that has a 50% efficiency for particles with an aerodynamic diameter of 10 µm (PM₁₀), generated by gas and electric cooking, on A549 epithelial cells with and without nitrogen dioxide (NO₂).
METHOD—Multiple indoor PM₁₀ samples were collected on Teflon filters during the use of gas or electric cookers. Interleukin-8 (IL-8) concentrations were measured with a sandwich enzyme linked immunosorbent assay (ELISA) system.
RESULTS—Treatment of A549 cells with PM₁₀ generated from gas cooking resulted in increased concentrations of IL-8 compared with untreated cells; particles from the electric cooker had no effect. NO₂ did not alter the concentration of IL-8.
CONCLUSION—PM₁₀ generated by gas cooking has the potential to cause proinflammatory effects in lung cells. This may have implications for susceptible people.


Keywords: indoor air pollution; PM₁₀; interleukin-8

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