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. 2002 Oct;59(10):655–663. doi: 10.1136/oem.59.10.655

Risk of bladder cancer in foundry workers: a meta-analysis

R Gaertner 1, G Theriault 1
PMCID: PMC1740225  PMID: 12356924

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Selected References

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  1. Andersen A., Barlow L., Engeland A., Kjaerheim K., Lynge E., Pukkala E. Work-related cancer in the Nordic countries. Scand J Work Environ Health. 1999;25 (Suppl 2):1–116. [PubMed] [Google Scholar]
  2. Andjelkovich D. A., Mathew R. M., Richardson R. B., Levine R. J. Mortality of iron foundry workers: I. Overall findings. J Occup Med. 1990 Jun;32(6):529–540. doi: 10.1097/00043764-199006000-00010. [DOI] [PubMed] [Google Scholar]
  3. Anton-Culver H., Lee-Feldstein A., Taylor T. H. Occupation and bladder cancer risk. Am J Epidemiol. 1992 Jul 1;136(1):89–94. doi: 10.1093/oxfordjournals.aje.a116424. [DOI] [PubMed] [Google Scholar]
  4. Armstrong B. G., Tremblay C. G., Cyr D., Thériault G. P. Estimating the relationship between exposure to tar volatiles and the incidence of bladder cancer in aluminum smelter workers. Scand J Work Environ Health. 1986 Oct;12(5):486–493. doi: 10.5271/sjweh.2109. [DOI] [PubMed] [Google Scholar]
  5. Armstrong B., Tremblay C., Theriault G. Compensating bladder cancer victims employed in aluminum reduction plants. J Occup Med. 1988 Oct;30(10):771–775. doi: 10.1097/00043764-198810000-00004. [DOI] [PubMed] [Google Scholar]
  6. Barbone F., Franceschi S., Talamini R., Bidoli E., La Vecchia C. Occupation and bladder cancer in Pordenone (north-east Italy): a case-control study. Int J Epidemiol. 1994 Feb;23(1):58–65. doi: 10.1093/ije/23.1.58. [DOI] [PubMed] [Google Scholar]
  7. Boffetta P., Jourenkova N., Gustavsson P. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control. 1997 May;8(3):444–472. doi: 10.1023/a:1018465507029. [DOI] [PubMed] [Google Scholar]
  8. Bonassi S., Merlo F., Pearce N., Puntoni R. Bladder cancer and occupational exposure to polycyclic aromatic hydrocarbons. Int J Cancer. 1989 Oct 15;44(4):648–651. doi: 10.1002/ijc.2910440415. [DOI] [PubMed] [Google Scholar]
  9. Burnett C. A., Silverman D. T., Lalich N. R. A comparison of analyses of occupational bladder cancer: death certificate vs. population-based case-control interview data. Am J Ind Med. 1994 May;25(5):677–688. doi: 10.1002/ajim.4700250507. [DOI] [PubMed] [Google Scholar]
  10. Burns P. B., Swanson G. M. Risk of urinary bladder cancer among blacks and whites: the role of cigarette use and occupation. Cancer Causes Control. 1991 Nov;2(6):371–379. doi: 10.1007/BF00054297. [DOI] [PubMed] [Google Scholar]
  11. Clavel J., Mandereau L., Limasset J. C., Hémon D., Cordier S. Occupational exposure to polycyclic aromatic hydrocarbons and the risk of bladder cancer: a French case-control study. Int J Epidemiol. 1994 Dec;23(6):1145–1153. doi: 10.1093/ije/23.6.1145. [DOI] [PubMed] [Google Scholar]
  12. Coggon D., Pannett B., Osmond C., Acheson E. D. A survey of cancer and occupation in young and middle aged men. II. Non-respiratory cancers. Br J Ind Med. 1986 Jun;43(6):381–386. doi: 10.1136/oem.43.6.381. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Dolin P. J., Cook-Mozaffari P. Occupation and bladder cancer: a death-certificate study. Br J Cancer. 1992 Sep;66(3):568–578. doi: 10.1038/bjc.1992.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Dubrow R., Wegman D. H. Cancer and occupation in Massachusetts: a death certificate study. Am J Ind Med. 1984;6(3):207–230. doi: 10.1002/ajim.4700060305. [DOI] [PubMed] [Google Scholar]
  15. Egan-Baum E., Miller B. A., Waxweiler R. J. Lung cancer and other mortality patterns among foundrymen. Scand J Work Environ Health. 1981;7 (Suppl 4):147–155. [PubMed] [Google Scholar]
  16. Egger M., Davey Smith G., Schneider M., Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997 Sep 13;315(7109):629–634. doi: 10.1136/bmj.315.7109.629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Firth H. M., Elwood J. M., Cox B., Herbison G. P. Historical cohort study of a New Zealand foundry and heavy engineering plant. Occup Environ Med. 1999 Feb;56(2):134–138. doi: 10.1136/oem.56.2.134. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Golka K., Bandel T., Schlaefke S., Reich S. E., Reckwitz T., Urfer W., Bremicker K. D., Neugebauer W., Soekeland J., Bolt H. M. Urothelial cancer of the bladder in an area of former coal, iron, and steel industries in Germany: a case-control study. Int J Occup Environ Health. 1998 Apr-Jun;4(2):79–84. doi: 10.1179/oeh.1998.4.2.79. [DOI] [PubMed] [Google Scholar]
  19. González C. A., López-Abente G., Errezola M., Escolar A., Riboli E., Izarzugaza I., Nebot M. Occupation and bladder cancer in Spain: a multi-centre case-control study. Int J Epidemiol. 1989 Sep;18(3):569–577. doi: 10.1093/ije/18.3.569. [DOI] [PubMed] [Google Scholar]
  20. Greenland S. Quantitative methods in the review of epidemiologic literature. Epidemiol Rev. 1987;9:1–30. doi: 10.1093/oxfordjournals.epirev.a036298. [DOI] [PubMed] [Google Scholar]
  21. Grimsrud T. K., Langseth H., Engeland A., Andersen A. Lung and bladder cancer in a Norwegian municipality with iron and steel producing industry: population based case-control studies. Occup Environ Med. 1998 Jun;55(6):387–392. doi: 10.1136/oem.55.6.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hall N. E., Rosenman K. D. Cancer by industry: analysis of a population-based cancer registry with an emphasis on blue-collar workers. Am J Ind Med. 1991;19(2):145–159. doi: 10.1002/ajim.4700190203. [DOI] [PubMed] [Google Scholar]
  23. Hansen A. M., Omland O., Poulsen O. M., Sherson D., Sigsgaard T., Christensen J. M., Overgaard E. Correlation between work process-related exposure to polycyclic aromatic hydrocarbons and urinary levels of alpha-naphthol, beta-naphthylamine and 1-hydroxypyrene in iron foundry workers. Int Arch Occup Environ Health. 1994;65(6):385–394. doi: 10.1007/BF00383249. [DOI] [PubMed] [Google Scholar]
  24. Hansen E. S. A cohort mortality study of foundry workers. Am J Ind Med. 1997 Sep;32(3):223–233. doi: 10.1002/(sici)1097-0274(199709)32:3<223::aid-ajim7>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  25. Hansen E. S. Cancer mortality among Danish molders. Am J Ind Med. 1991;20(3):401–409. doi: 10.1002/ajim.4700200312. [DOI] [PubMed] [Google Scholar]
  26. Hemminki K., Dickey C., Karlsson S., Bell D., Hsu Y., Tsai W. Y., Mooney L. A., Savela K., Perera F. P. Aromatic DNA adducts in foundry workers in relation to exposure, life style and CYP1A1 and glutathione transferase M1 genotype. Carcinogenesis. 1997 Feb;18(2):345–350. doi: 10.1093/carcin/18.2.345. [DOI] [PubMed] [Google Scholar]
  27. Iscovich J., Castelletto R., Estève J., Muñoz N., Colanzi R., Coronel A., Deamezola I., Tassi V., Arslan A. Tobacco smoking, occupational exposure and bladder cancer in Argentina. Int J Cancer. 1987 Dec 15;40(6):734–740. doi: 10.1002/ijc.2910400604. [DOI] [PubMed] [Google Scholar]
  28. Jensen O. M., Wahrendorf J., Knudsen J. B., Sørensen B. L. The Copenhagen case-referent study on bladder cancer. Risks among drivers, painters and certain other occupations. Scand J Work Environ Health. 1987 Apr;13(2):129–134. doi: 10.5271/sjweh.2070. [DOI] [PubMed] [Google Scholar]
  29. Knecht U., Elliehausen H. J., Woitowitz H. J. Gaseous and adsorbed PAH in an iron foundry. Br J Ind Med. 1986 Dec;43(12):834–838. doi: 10.1136/oem.43.12.834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Koskela R. S. Mortality, morbidity and health selection among metal workers. Scand J Work Environ Health. 1997;23 (Suppl 2):1–80. [PubMed] [Google Scholar]
  31. Kubiak R., Belowski J., Szczeklik J., Smolik E., Mielzynska D., Baj M., Szczesna A. Biomarkers of carcinogenesis in humans exposed to polycyclic aromatic hydrocarbons. Mutat Res. 1999 Sep 30;445(2):175–180. doi: 10.1016/s1383-5718(99)00124-2. [DOI] [PubMed] [Google Scholar]
  32. Kunze E., Chang-Claude J., Frentzel-Beyme R. Life style and occupational risk factors for bladder cancer in Germany. A case-control study. Cancer. 1992 Apr 1;69(7):1776–1790. doi: 10.1002/1097-0142(19920401)69:7<1776::aid-cncr2820690721>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  33. Lindstedt G., Sollenberg J. Polycyclic aromatic hydrocarbons in the occupational environment: with special reference to benzo[a]pyrene measurements in Swedish industry. Scand J Work Environ Health. 1982 Mar;8(1):1–19. doi: 10.5271/sjweh.2503. [DOI] [PubMed] [Google Scholar]
  34. Malker H. S., McLaughlin J. K., Silverman D. T., Ericsson J. L., Stone B. J., Weiner J. A., Malker B. K., Blot W. J. Occupational risks for bladder cancer among men in Sweden. Cancer Res. 1987 Dec 15;47(24 Pt 1):6763–6766. [PubMed] [Google Scholar]
  35. Mallin K. A nested case-control study of bladder cancer incidence in a steel manufacturing plant. Am J Ind Med. 1998 Oct;34(4):393–398. doi: 10.1002/(sici)1097-0274(199810)34:4<393::aid-ajim14>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  36. Mallin K., Rubin M., Joo E. Occupational cancer mortality in Illinois white and black males, 1979-1984, for seven cancer sites. Am J Ind Med. 1989;15(6):699–717. doi: 10.1002/ajim.4700150609. [DOI] [PubMed] [Google Scholar]
  37. Notani P. N., Shah P., Jayant K., Balakrishnan V. Occupation and cancers of the lung and bladder: a case-control study in Bombay. Int J Epidemiol. 1993 Apr;22(2):185–191. doi: 10.1093/ije/22.2.185. [DOI] [PubMed] [Google Scholar]
  38. Omland O., Sherson D., Hansen A. M., Sigsgaard T., Autrup H., Overgaard E. Urinary 1-hydroxypyrene, a PAH biomarker in foundry workers. Cancer Detect Prev. 1996;20(1):57–62. [PubMed] [Google Scholar]
  39. Park R. M. Mortality at an automotive engine foundry and machining complex. J Occup Environ Med. 2001 May;43(5):483–493. doi: 10.1097/00043764-200105000-00009. [DOI] [PubMed] [Google Scholar]
  40. Perera F. P., Hemminki K., Young T. L., Brenner D., Kelly G., Santella R. M. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Cancer Res. 1988 Apr 15;48(8):2288–2291. [PubMed] [Google Scholar]
  41. Pesch B., Haerting J., Ranft U., Klimpel A., Oelschlägel B., Schill W. Occupational risk factors for urothelial carcinoma: agent-specific results from a case-control study in Germany. MURC Study Group. Multicenter Urothelial and Renal Cancer. Int J Epidemiol. 2000 Apr;29(2):238–247. doi: 10.1093/ije/29.2.238. [DOI] [PubMed] [Google Scholar]
  42. Pirastu R., Iavarone I., Comba P. Bladder cancer: a selected review of the epidemiological literature. Ann Ist Super Sanita. 1996;32(1):3–20. [PubMed] [Google Scholar]
  43. Porru S., Aulenti V., Donato F., Boffetta P., Fazioli R., Cosciani Cunico S., Alessio L. Bladder cancer and occupation: a case-control study in northern Italy. Occup Environ Med. 1996 Jan;53(1):6–10. doi: 10.1136/oem.53.1.6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  44. Risch H. A., Burch J. D., Miller A. B., Hill G. B., Steele R., Howe G. R. Occupational factors and the incidence of cancer of the bladder in Canada. Br J Ind Med. 1988 Jun;45(6):361–367. doi: 10.1136/oem.45.6.361. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Rotimi C., Austin H., Delzell E., Day C., Macaluso M., Honda Y. Retrospective follow-up study of foundry and engine plant workers. Am J Ind Med. 1993 Oct;24(4):485–498. doi: 10.1002/ajim.4700240412. [DOI] [PubMed] [Google Scholar]
  46. Santella R. M., Hemminki K., Tang D. L., Paik M., Ottman R., Young T. L., Savela K., Vodickova L., Dickey C., Whyatt R. Polycyclic aromatic hydrocarbon-DNA adducts in white blood cells and urinary 1-hydroxypyrene in foundry workers. Cancer Epidemiol Biomarkers Prev. 1993 Jan-Feb;2(1):59–62. [PubMed] [Google Scholar]
  47. Schifflers E., Jamart J., Renard V. Tobacco and occupation as risk factors in bladder cancer: a case-control study in southern Belgium. Int J Cancer. 1987 Mar 15;39(3):287–292. doi: 10.1002/ijc.2910390304. [DOI] [PubMed] [Google Scholar]
  48. Schoenberg J. B., Stemhagen A., Mogielnicki A. P., Altman R., Abe T., Mason T. J. Case-control study of bladder cancer in New Jersey. I. Occupational exposures in white males. J Natl Cancer Inst. 1984 May;72(5):973–981. [PubMed] [Google Scholar]
  49. Seldén A. I., Westberg H. B., Axelson O. Cancer morbidity in workers at aluminum foundries and secondary aluminum smelters. Am J Ind Med. 1997 Nov;32(5):467–477. doi: 10.1002/(sici)1097-0274(199711)32:5<467::aid-ajim6>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  50. Sherson D., Sabro P., Sigsgaard T., Johansen F., Autrup H. Biological monitoring of foundry workers exposed to polycyclic aromatic hydrocarbons. Br J Ind Med. 1990 Jul;47(7):448–453. doi: 10.1136/oem.47.7.448. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Sherson D., Sigsgaard T., Overgaard E., Loft S., Poulsen H. E., Jongeneelen F. J. Interaction of smoking, uptake of polycyclic aromatic hydrocarbons, and cytochrome P450IA2 activity among foundry workers. Br J Ind Med. 1992 Mar;49(3):197–202. doi: 10.1136/oem.49.3.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Sherson D., Svane O., Lynge E. Cancer incidence among foundry workers in Denmark. Arch Environ Health. 1991 Mar-Apr;46(2):75–81. doi: 10.1080/00039896.1991.9937432. [DOI] [PubMed] [Google Scholar]
  53. Shore R. E., Gardner M. J., Pannett B. Ethylene oxide: an assessment of the epidemiological evidence on carcinogenicity. Br J Ind Med. 1993 Nov;50(11):971–997. doi: 10.1136/oem.50.11.971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  54. Siemiatycki J., Dewar R., Nadon L., Gérin M. Occupational risk factors for bladder cancer: results from a case-control study in Montreal, Quebec, Canada. Am J Epidemiol. 1994 Dec 15;140(12):1061–1080. doi: 10.1093/oxfordjournals.aje.a117207. [DOI] [PubMed] [Google Scholar]
  55. Silverman D. T., Hoover R. N., Albert S., Graff K. M. Occupation and cancer of the lower urinary tract in Detroit. J Natl Cancer Inst. 1983 Feb;70(2):237–245. [PubMed] [Google Scholar]
  56. Silverman D. T., Levin L. I., Hoover R. N., Hartge P. Occupational risks of bladder cancer in the United States: I. White men. J Natl Cancer Inst. 1989 Oct 4;81(19):1472–1480. doi: 10.1093/jnci/81.19.1472. [DOI] [PubMed] [Google Scholar]
  57. Silverman D. T., Levin L. I., Hoover R. N. Occupational risks of bladder cancer in the United States: II Nonwhite men. J Natl Cancer Inst. 1989 Oct 4;81(19):1480–1483. doi: 10.1093/jnci/81.19.1480. [DOI] [PubMed] [Google Scholar]
  58. Silverstein M., Maizlish N., Park R., Silverstein B., Brodsky L., Mirer F. Mortality among ferrous foundry workers. Am J Ind Med. 1986;10(1):27–43. doi: 10.1002/ajim.4700100105. [DOI] [PubMed] [Google Scholar]
  59. Sitas F., Douglas A. J., Webster E. C. Respiratory disease mortality patterns among South African iron moulders. Br J Ind Med. 1989 May;46(5):310–315. doi: 10.1136/oem.46.5.310. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Sorahan T., Faux A. M., Cooke M. A. Mortality among a cohort of United Kingdom steel foundry workers with special reference to cancers of the stomach and lung, 1946-90. Occup Environ Med. 1994 May;51(5):316–322. doi: 10.1136/oem.51.5.316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  61. Sorahan T., Hamilton L., Wallace D. M., Bathers S., Gardiner K., Harrington J. M. Occupational urothelial tumours: a regional case-control study. Br J Urol. 1998 Jul;82(1):25–32. doi: 10.1046/j.1464-410x.1998.00690.x. [DOI] [PubMed] [Google Scholar]
  62. Spinelli J. J., Gallagher R. P., Band P. R., Threlfall W. J., Raynor D., Schellekens H. Occupational associations among British Columbia male cancer patients. Can J Public Health. 1990 Jul-Aug;81(4):254–258. [PubMed] [Google Scholar]
  63. Starzyński Z., Marek K., Kujawska A., Szymczak W. Mortality among different occupational groups of workers with pneumoconiosis: results from a register-based cohort study. Am J Ind Med. 1996 Dec;30(6):718–725. doi: 10.1002/(SICI)1097-0274(199612)30:6<718::AID-AJIM8>3.0.CO;2-M. [DOI] [PubMed] [Google Scholar]
  64. Steenland K., Burnett C., Osorio A. M. A case-control study of bladder cancer using city directories as a source of occupational data. Am J Epidemiol. 1987 Aug;126(2):247–257. doi: 10.1093/aje/126.2.247. [DOI] [PubMed] [Google Scholar]
  65. Steineck G., Plato N., Alfredsson L., Norell S. E. Industry-related urothelial carcinogens: application of a job-exposure matrix to census data. Am J Ind Med. 1989;16(2):209–224. doi: 10.1002/ajim.4700160212. [DOI] [PubMed] [Google Scholar]
  66. Steineck G., Plato N., Norell S. E., Hogstedt C. Urothelial cancer and some industry-related chemicals: an evaluation of the epidemiologic literature. Am J Ind Med. 1990;17(3):371–391. doi: 10.1002/ajim.4700170310. [DOI] [PubMed] [Google Scholar]
  67. Steinmaus C. M., Nuñez S., Smith A. H. Diet and bladder cancer: a meta-analysis of six dietary variables. Am J Epidemiol. 2000 Apr 1;151(7):693–702. doi: 10.1093/oxfordjournals.aje.a010264. [DOI] [PubMed] [Google Scholar]
  68. Sterne J. A., Egger M. Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol. 2001 Oct;54(10):1046–1055. doi: 10.1016/s0895-4356(01)00377-8. [DOI] [PubMed] [Google Scholar]
  69. Sutton A. J., Duval S. J., Tweedie R. L., Abrams K. R., Jones D. R. Empirical assessment of effect of publication bias on meta-analyses. BMJ. 2000 Jun 10;320(7249):1574–1577. doi: 10.1136/bmj.320.7249.1574. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Swanson G. M., Burns P. B. Cancer incidence among women in the workplace: a study of the association between occupation and industry and 11 cancer sites. J Occup Environ Med. 1995 Mar;37(3):282–287. doi: 10.1097/00043764-199503000-00002. [DOI] [PubMed] [Google Scholar]
  71. Tola S., Tenho M., Korkala M. L., Järvinen E. Cancer of the urinary bladder in Finland: association with occupation. Int Arch Occup Environ Health. 1980;46(1):43–51. doi: 10.1007/BF00377458. [DOI] [PubMed] [Google Scholar]
  72. Verma D. K., Muir D. C., Cunliffe S., Julian J. A., Vogt J. H., Rosenfeld J., Chovil A. Polycyclic aromatic hydrocarbons in Ontario foundry environments. Ann Occup Hyg. 1982;25(1):17–25. doi: 10.1093/annhyg/25.1.17. [DOI] [PubMed] [Google Scholar]
  73. Vineis P., Magnani C. Occupation and bladder cancer in males: a case-control study. Int J Cancer. 1985 May 15;35(5):599–606. doi: 10.1002/ijc.2910350506. [DOI] [PubMed] [Google Scholar]
  74. Xu Z., Pan G. W., Liu L. M., Brown L. M., Guan D. X., Xiu Q., Sheng J. H., Stone B. J., Dosemeci M., Fraumeni J. F., Jr Cancer risks among iron and steel workers in Anshan, China, Part I: Proportional mortality ratio analysis. Am J Ind Med. 1996 Jul;30(1):1–6. doi: 10.1002/(SICI)1097-0274(199607)30:1<1::AID-AJIM1>3.0.CO;2-5. [DOI] [PubMed] [Google Scholar]
  75. Zheng W., McLaughlin J. K., Gao Y. T., Silverman D. T., Gao R. N., Blot W. J. Bladder cancer and occupation in Shanghai, 1980-1984. Am J Ind Med. 1992;21(6):877–885. doi: 10.1002/ajim.4700210611. [DOI] [PubMed] [Google Scholar]

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