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. 2002 Sep;59(9):620–624. doi: 10.1136/oem.59.9.620

Validity of empirical models of exposure in asphalt paving

I Burstyn 1, P Boffetta 1, G Burr 1, A Cenni 1, U Knecht 1, G Sciarra 1, H Kromhout 1
PMCID: PMC1740368  PMID: 12205236

Abstract

Aims: To investigate the validity of empirical models of exposure to bitumen fume and benzo(a)pyrene, developed for a historical cohort study of asphalt paving in Western Europe.

Methods: Validity was evaluated using data from the USA, Italy, and Germany not used to develop the original models. Correlation between observed and predicted exposures was examined. Bias and precision were estimated.

Results: Models were imprecise. Furthermore, predicted bitumen fume exposures tended to be lower (-70%) than concentrations found during paving in the USA. This apparent bias might be attributed to differences between Western European and USA paving practices. Evaluation of the validity of the benzo(a)pyrene exposure model revealed a similar to expected effect of re-paving and a larger than expected effect of tar use. Overall, benzo(a)pyrene models underestimated exposures by 51%.

Conclusions: Possible bias as a result of underestimation of the impact of coal tar on benzo(a)pyrene exposure levels must be explored in sensitivity analysis of the exposure–response relation. Validation of the models, albeit limited, increased our confidence in their applicability to exposure assessment in the historical cohort study of cancer risk among asphalt workers.

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Selected References

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  1. Armstrong T. W., Pearlman E. D., Schnatter A. R., Bowes S. M., 3rd, Murray N., Nicolich M. J. Retrospective benzene and total hydrocarbon exposure assessment for a petroleum marketing and distribution worker epidemiology study. Am Ind Hyg Assoc J. 1996 Apr;57(4):333–343. doi: 10.1080/15428119691014864. [DOI] [PubMed] [Google Scholar]
  2. Burstyn I., Kromhout H. Are the members of a paving crew uniformly exposed to bitumen fume, organic vapor, and benzo(a)pyrene? Risk Anal. 2000 Oct;20(5):653–663. doi: 10.1111/0272-4332.205059. [DOI] [PubMed] [Google Scholar]
  3. Burstyn I., Kromhout H., Boffetta P. Literature review of levels and determinants of exposure to potential carcinogens and other agents in the road construction industry. AIHAJ. 2000 Sep-Oct;61(5):715–726. doi: 10.1080/15298660008984582. [DOI] [PubMed] [Google Scholar]
  4. Burstyn I., Kromhout H., Cruise P. J., Brennan P. Designing an international industrial hygiene database of exposures among workers in the asphalt industry. Ann Occup Hyg. 2000 Jan;44(1):57–66. [PubMed] [Google Scholar]
  5. Burstyn I., Kromhout H., Kauppinen T., Heikkilä P., Boffetta P. Statistical modelling of the determinants of historical exposure to bitumen and polycyclic aromatic hydrocarbons among paving workers. Ann Occup Hyg. 2000 Jan;44(1):43–56. [PubMed] [Google Scholar]
  6. Burstyn I., Teschke K. Studying the determinants of exposure: a review of methods. Am Ind Hyg Assoc J. 1999 Jan-Feb;60(1):57–72. doi: 10.1080/00028899908984423. [DOI] [PubMed] [Google Scholar]
  7. Dosemeci M., Rothman N., Yin S. N., Li G. L., Linet M., Wacholder S., Chow W. H., Hayes R. B. Validation of benzene exposure assessment. Ann N Y Acad Sci. 1997 Dec 26;837:114–121. doi: 10.1111/j.1749-6632.1997.tb56868.x. [DOI] [PubMed] [Google Scholar]
  8. Heederik D., Attfield M. Characterization of dust exposure for the study of chronic occupational lung disease: a comparison of different exposure assessment strategies. Am J Epidemiol. 2000 May 15;151(10):982–990. doi: 10.1093/oxfordjournals.aje.a010142. [DOI] [PubMed] [Google Scholar]
  9. Hornung R. W., Greife A. L., Stayner L. T., Steenland N. K., Herrick R. F., Elliott L. J., Ringenburg V. L., Morawetz J. Statistical model for prediction of retrospective exposure to ethylene oxide in an occupational mortality study. Am J Ind Med. 1994 Jun;25(6):825–836. doi: 10.1002/ajim.4700250607. [DOI] [PubMed] [Google Scholar]
  10. Hornung R. W., Herrick R. F., Stewart P. A., Utterback D. F., Feigley C. E., Wall D. K., Douthit D. E., Hayes R. B. An experimental design approach to retrospective exposure assessment. Am Ind Hyg Assoc J. 1996 Mar;57(3):251–256. doi: 10.1080/15428119691014972. [DOI] [PubMed] [Google Scholar]
  11. Knecht U., Woitowitz H. J. Risk of cancer from the use of tar bitumen in road works. Br J Ind Med. 1989 Jan;46(1):24–30. doi: 10.1136/oem.46.1.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kromhout H., Loomis D. P., Kleckner R. C., Savitz D. A. Sensitivity of the relation between cumulative magnetic field exposure and brain cancer mortality to choice of monitoring data grouping scheme. Epidemiology. 1997 Jul;8(4):442–445. doi: 10.1097/00001648-199707000-00016. [DOI] [PubMed] [Google Scholar]
  13. Kromhout H., Loomis D. P., Kleckner R. C. Uncertainty in the relation between exposure to magnetic fields and brain cancer due to assessment and assignment of exposure and analytical methods in dose-response modeling. Ann N Y Acad Sci. 1999;895:141–155. doi: 10.1111/j.1749-6632.1999.tb08082.x. [DOI] [PubMed] [Google Scholar]
  14. Loomis A., Kromhout H., Kleckner R. C., Savitz D. A. Effects of the analytical treatment of exposure data on associations of cancer and occupational magnetic field exposure. Am J Ind Med. 1998 Jul;34(1):49–56. doi: 10.1002/(sici)1097-0274(199807)34:1<49::aid-ajim7>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  15. Partanen T., Boffetta P. Cancer risk in asphalt workers and roofers: review and meta-analysis of epidemiologic studies. Am J Ind Med. 1994 Dec;26(6):721–740. doi: 10.1002/ajim.4700260602. [DOI] [PubMed] [Google Scholar]
  16. Rybicki B. A., Peterson E. L., Johnson C. C., Kortsha G. X., Cleary W. M., Gorell J. M. Intra- and inter-rater agreement in the assessment of occupational exposure to metals. Int J Epidemiol. 1998 Apr;27(2):269–273. doi: 10.1093/ije/27.2.269. [DOI] [PubMed] [Google Scholar]
  17. Seixas N. S., Checkoway H. Exposure assessment in industry specific retrospective occupational epidemiology studies. Occup Environ Med. 1995 Oct;52(10):625–633. doi: 10.1136/oem.52.10.625. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Seixas N. S., Robins T. G., Becker M. A novel approach to the characterization of cumulative exposure for the study of chronic occupational disease. Am J Epidemiol. 1993 Feb 15;137(4):463–471. doi: 10.1093/oxfordjournals.aje.a116695. [DOI] [PubMed] [Google Scholar]
  19. Tielemans E., Heederik D., Burdorf A., Vermeulen R., Veulemans H., Kromhout H., Hartog K. Assessment of occupational exposures in a general population: comparison of different methods. Occup Environ Med. 1999 Mar;56(3):145–151. doi: 10.1136/oem.56.3.145. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. van Tongeren M. J., Kromhout H., Gardiner K., Calvert I. A., Harrington J. M. Assessment of the sensitivity of the relation between current exposure to carbon black and lung function parameters when using different grouping schemes. Am J Ind Med. 1999 Nov;36(5):548–556. doi: 10.1002/(sici)1097-0274(199911)36:5<548::aid-ajim7>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]

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