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. 2003 May;60(5):348–351. doi: 10.1136/oem.60.5.348

Breast cancer and serum organochlorine residues

C Charlier 1, A Albert 1, P Herman 1, E Hamoir 1, U Gaspard 1, M Meurisse 1, G Plomteux 1
PMCID: PMC1740527  PMID: 12709520

Abstract

Background: Controversy still exists about the breast carcinogenic properties in humans of environmental xenoestrogens (organochlorines), justifying new investigations.

Aims: To compare the blood levels of total dichlorodiphenyltrichloroethane (DDT) and hexachlorobenzene (HCB) in samples collected at the time of breast cancer discovery, in order to avoid the potential consequences of body weight change (after chemotherapy or radiotherapy) on the pesticide residue levels.

Methods: Blood levels of HCB and total DDT (we calculated total DDT concentrations by adding all DDT and DDE isomers) were compared in 159 women with breast cancer and 250 presumably healthy controls. Risk of breast cancer associated with organochlorine concentration was evaluated.

Results: Mean levels of total DDT and HCB were significantly higher for breast cancer patients than for controls. No differences in serum levels of total DDT or HCB were found between oestrogen receptor positive and oestrogen receptor negative patients with breast cancer.

Conclusions: These results add to the growing evidence that certain persistent pollutants may occur in higher concentrations in blood samples from breast cancer patients than controls.

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Selected References

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  1. Adami H. O., Lipworth L., Titus-Ernstoff L., Hsieh C. C., Hanberg A., Ahlborg U., Baron J., Trichopoulos D. Organochlorine compounds and estrogen-related cancers in women. Cancer Causes Control. 1995 Nov;6(6):551–566. doi: 10.1007/BF00054165. [DOI] [PubMed] [Google Scholar]
  2. Blair A., Grauman D. J., Lubin J. H., Fraumeni J. F., Jr Lung cancer and other causes of death among licensed pesticide applicators. J Natl Cancer Inst. 1983 Jul;71(1):31–37. [PubMed] [Google Scholar]
  3. Bordet F., Mallet J., Maurice L., Borrel S., Venant A. Organochlorine pesticide and PCB congener content of French human milk. Bull Environ Contam Toxicol. 1993 Mar;50(3):425–432. doi: 10.1007/BF00197204. [DOI] [PubMed] [Google Scholar]
  4. Charlier Corinne J., Plomteux Guy J. Determination of organochlorine pesticide residues in the blood of healthy individuals. Clin Chem Lab Med. 2002 Apr;40(4):361–364. doi: 10.1515/CCLM.2002.058. [DOI] [PubMed] [Google Scholar]
  5. Davis D. L., Bradlow H. L., Wolff M., Woodruff T., Hoel D. G., Anton-Culver H. Medical hypothesis: xenoestrogens as preventable causes of breast cancer. Environ Health Perspect. 1993 Oct;101(5):372–377. doi: 10.1289/ehp.93101372. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Demers A., Ayotte P., Brisson J., Dodin S., Robert J., Dewailly E. Risk and aggressiveness of breast cancer in relation to plasma organochlorine concentrations. Cancer Epidemiol Biomarkers Prev. 2000 Feb;9(2):161–166. [PubMed] [Google Scholar]
  7. Dewailly E., Dodin S., Verreault R., Ayotte P., Sauvé L., Morin J., Brisson J. High organochlorine body burden in women with estrogen receptor-positive breast cancer. J Natl Cancer Inst. 1994 Feb 2;86(3):232–234. doi: 10.1093/jnci/86.3.232. [DOI] [PubMed] [Google Scholar]
  8. Dogheim S. M., Mohamed el-Z, Gad Alla S. A., el-Saied S., Emel S. Y., Mohsen A. M., Fahmy S. M. Monitoring of pesticide residues in human milk, soil, water, and food samples collected from Kafr El-Zayat Governorate. J AOAC Int. 1996 Jan-Feb;79(1):111–116. [PubMed] [Google Scholar]
  9. Dorgan J. F., Brock J. W., Rothman N., Needham L. L., Miller R., Stephenson H. E., Jr, Schussler N., Taylor P. R. Serum organochlorine pesticides and PCBs and breast cancer risk: results from a prospective analysis (USA). Cancer Causes Control. 1999 Feb;10(1):1–11. doi: 10.1023/a:1008824131727. [DOI] [PubMed] [Google Scholar]
  10. Falck F., Jr, Ricci A., Jr, Wolff M. S., Godbold J., Deckers P. Pesticides and polychlorinated biphenyl residues in human breast lipids and their relation to breast cancer. Arch Environ Health. 1992 Mar-Apr;47(2):143–146. [PubMed] [Google Scholar]
  11. Gellert R. J., Heinrichs W. L., Swerdloff R. S. DDT homologues: estrogen-like effects on the vagina, uterus and pituitary of the rat. Endocrinology. 1972 Oct;91(4):1095–1100. doi: 10.1210/endo-91-4-1095. [DOI] [PubMed] [Google Scholar]
  12. Güttes S., Failing K., Neumann K., Kleinstein J., Georgii S., Brunn H. Chlororganic pesticides and polychlorinated biphenyls in breast tissue of women with benign and malignant breast disease. Arch Environ Contam Toxicol. 1998 Jul;35(1):140–147. doi: 10.1007/s002449900361. [DOI] [PubMed] [Google Scholar]
  13. Hoffman W. Organochlorine compounds: Risk of non-Hodgkin's lymphoma and breast cancer? Arch Environ Health. 1996 May-Jun;51(3):189–192. doi: 10.1080/00039896.1996.9936015. [DOI] [PubMed] [Google Scholar]
  14. Hunter D. J., Hankinson S. E., Laden F., Colditz G. A., Manson J. E., Willett W. C., Speizer F. E., Wolff M. S. Plasma organochlorine levels and the risk of breast cancer. N Engl J Med. 1997 Oct 30;337(18):1253–1258. doi: 10.1056/NEJM199710303371801. [DOI] [PubMed] [Google Scholar]
  15. Høyer A. P., Grandjean P., Jørgensen T., Brock J. W., Hartvig H. B. Organochlorine exposure and risk of breast cancer. Lancet. 1998 Dec 5;352(9143):1816–1820. doi: 10.1016/S0140-6736(98)04504-8. [DOI] [PubMed] [Google Scholar]
  16. Kang K. S., Wilson M. R., Hayashi T., Chang C. C., Trosko J. E. Inhibition of gap junctional intercellular communication in normal human breast epithelial cells after treatment with pesticides, PCBs, and PBBs, alone or in mixtures. Environ Health Perspect. 1996 Feb;104(2):192–200. doi: 10.1289/ehp.96104192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Key T., Reeves G. Organochlorines in the environment and breast cancer. BMJ. 1994 Jun 11;308(6943):1520–1521. doi: 10.1136/bmj.308.6943.1520. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Krieger N., Wolff M. S., Hiatt R. A., Rivera M., Vogelman J., Orentreich N. Breast cancer and serum organochlorines: a prospective study among white, black, and Asian women. J Natl Cancer Inst. 1994 Apr 20;86(8):589–599. doi: 10.1093/jnci/86.8.589. [DOI] [PubMed] [Google Scholar]
  19. Larsen B. R., Turrio-Baldassarri L., Nilsson T., Iacovella N., Di Domenico A., Montagna M., Facchetti S. Toxic PCB congeners and organochlorine pesticides in Italian human milk. Ecotoxicol Environ Saf. 1994 Jun;28(1):1–13. doi: 10.1006/eesa.1994.1029. [DOI] [PubMed] [Google Scholar]
  20. Liljegren G., Hardell L., Lindström G., Dahl P., Magnuson A. Case-control study on breast cancer and adipose tissue concentrations of congener specific polychlorinated biphenyls, DDE and hexachlorobenzene. Eur J Cancer Prev. 1998 Apr;7(2):135–140. [PubMed] [Google Scholar]
  21. MacMahon B., Cole P., Brown J. Etiology of human breast cancer: a review. J Natl Cancer Inst. 1973 Jan;50(1):21–42. doi: 10.1093/jnci/50.1.21. [DOI] [PubMed] [Google Scholar]
  22. Mussalo-Rauhamaa H., Häsänen E., Pyysalo H., Antervo K., Kauppila R., Pantzar P. Occurrence of beta-hexachlorocyclohexane in breast cancer patients. Cancer. 1990 Nov 15;66(10):2124–2128. doi: 10.1002/1097-0142(19901115)66:10<2124::aid-cncr2820661014>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
  23. Nelson J. A. Effects of dichlorodiphenyltrichloroethane (DDT) analogs and polychlorinated biphenyl (PCB) mixtures on 17beta-(3H)estradiol binding to rat uterine receptor. Biochem Pharmacol. 1974 Jan 15;23(2):447–451. doi: 10.1016/0006-2952(74)90436-5. [DOI] [PubMed] [Google Scholar]
  24. Robison A. K., Sirbasku D. A., Stancel G. M. DDT supports the growth of an estrogen-responsive tumor. Toxicol Lett. 1985 Sep;27(1-3):109–113. doi: 10.1016/0378-4274(85)90127-4. [DOI] [PubMed] [Google Scholar]
  25. Romieu I., Hernandez-Avila M., Lazcano-Ponce E., Weber J. P., Dewailly E. Breast cancer, lactation history, and serum organochlorines. Am J Epidemiol. 2000 Aug 15;152(4):363–370. doi: 10.1093/aje/152.4.363. [DOI] [PubMed] [Google Scholar]
  26. Safe S. H. Environmental and dietary estrogens and human health: is there a problem? Environ Health Perspect. 1995 Apr;103(4):346–351. doi: 10.1289/ehp.95103346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Unger M., Kiaer H., Blichert-Toft M., Olsen J., Clausen J. Organochlorine compounds in human breast fat from deceased with and without breast cancer and in a biopsy material from newly diagnosed patients undergoing breast surgery. Environ Res. 1984 Jun;34(1):24–28. doi: 10.1016/0013-9351(84)90072-0. [DOI] [PubMed] [Google Scholar]
  28. Wolff M. S., Toniolo P. G. Environmental organochlorine exposure as a potential etiologic factor in breast cancer. Environ Health Perspect. 1995 Oct;103 (Suppl 7):141–145. doi: 10.1289/ehp.95103s7141. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Wolff M. S., Toniolo P. G., Lee E. W., Rivera M., Dubin N. Blood levels of organochlorine residues and risk of breast cancer. J Natl Cancer Inst. 1993 Apr 21;85(8):648–652. doi: 10.1093/jnci/85.8.648. [DOI] [PubMed] [Google Scholar]
  30. Wolff M. S., Zeleniuch-Jacquotte A., Dubin N., Toniolo P. Risk of breast cancer and organochlorine exposure. Cancer Epidemiol Biomarkers Prev. 2000 Mar;9(3):271–277. [PubMed] [Google Scholar]
  31. Zheng T., Holford T. R., Mayne S. T., Tessari J., Owens P. H., Zahm S. H., Zhang B., Dubrow R., Ward B., Carter D. Environmental exposure to hexachlorobenzene (HCB) and risk of female breast cancer in Connecticut. Cancer Epidemiol Biomarkers Prev. 1999 May;8(5):407–411. [PubMed] [Google Scholar]

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