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. 2003 Jun;60(6):451–457. doi: 10.1136/oem.60.6.451

Lung cancer mortality among chromate production workers

R Luippold 1, K Mundt 1, R Austin 1, E Liebig 1, J Panko 1, C Crump 1, K Crump 1, D Proctor 1
PMCID: PMC1740552  PMID: 12771398

Abstract

Aims: To assess mortality in 1997 among 493 former workers of a US chromate production plant employed for at least one year between 1940 and 1972.

Methods: Cohort members were followed for mortality to 31 December 1997. Standardised mortality ratios (SMRs) were calculated for selected cause specific categories of death including lung cancer. Lung cancer mortality was investigated further by calculation of SMRs stratified by year of hire, duration of employment, time since hire, and categories of cumulative exposure to Cr(VI).

Results: Including 51 deaths due to lung cancer, 303 deaths occurred. SMRs were significantly increased for all causes combined (SMR = 129), all cancers combined (SMR = 155), and lung cancer (SMR = 241). A trend test showed a strong relation between lung cancer mortality and cumulative hexavalent exposure. Lung cancer mortality was increased for the highest cumulative exposure categories (⩾1.05 to <2.70 mg/m3-years, SMR = 365; ⩾2.70 to 23 mg/m3-years, SMR = 463), but not for the first three exposure groups. Significantly increased SMRs were also found for year of hire before 1960, 20 or more years of exposed employment, and latency of 20 or more years.

Conclusions: The finding of an increased risk of lung cancer mortality associated with Cr(VI) exposure is consistent with previous reports. Stratified analysis of lung cancer mortality by cumulative exposure suggests a possible threshold effect, as risk is significantly increased only at exposure levels over 1.05 mg/m3-years. Though a threshold is consistent with published toxicological evidence, this finding must be interpreted cautiously because the data are also consistent with a linear dose response.

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Selected References

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  1. BOURNE H. G., Jr, YEE H. T. Occupational cancer in a chromate plant. An environmental appraisal. Ind Med Surg. 1950 Dec;19(12):563–567. [PubMed] [Google Scholar]
  2. Davies J. M., Easton D. F., Bidstrup P. L. Mortality from respiratory cancer and other causes in United Kingdom chromate production workers. Br J Ind Med. 1991 May;48(5):299–313. doi: 10.1136/oem.48.5.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. De Flora S. Threshold mechanisms and site specificity in chromium(VI) carcinogenesis. Carcinogenesis. 2000 Apr;21(4):533–541. doi: 10.1093/carcin/21.4.533. [DOI] [PubMed] [Google Scholar]
  4. Friede A., Reid J. A., Ory H. W. CDC WONDER: a comprehensive on-line public health information system of the Centers for Disease Control and Prevention. Am J Public Health. 1993 Sep;83(9):1289–1294. doi: 10.2105/ajph.83.9.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gibb H. J., Lees P. S., Pinsky P. F., Rooney B. C. Lung cancer among workers in chromium chemical production. Am J Ind Med. 2000 Aug;38(2):115–126. doi: 10.1002/1097-0274(200008)38:2<115::aid-ajim1>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  6. Hayes R. B., Sheffet A., Spirtas R. Cancer mortality among a cohort of chromium pigment workers. Am J Ind Med. 1989;16(2):127–133. doi: 10.1002/ajim.4700160204. [DOI] [PubMed] [Google Scholar]
  7. Jones R. E. Hexavalent chrome: threshold concept for carcinogenicity. Biomed Environ Sci. 1990 Mar;3(1):20–34. [PubMed] [Google Scholar]
  8. Korallus U., Ulm K., Steinmann-Steiner-Haldenstaett W. Bronchial carcinoma mortality in the German chromate-producing industry: the effects of process modification. Int Arch Occup Environ Health. 1993;65(3):171–178. doi: 10.1007/BF00381153. [DOI] [PubMed] [Google Scholar]
  9. Langård S. One hundred years of chromium and cancer: a review of epidemiological evidence and selected case reports. Am J Ind Med. 1990;17(2):189–215. doi: 10.1002/ajim.4700170205. [DOI] [PubMed] [Google Scholar]
  10. Levy L. S., Martin P. A., Bidstrup P. L. Investigation of the potential carcinogenicity of a range of chromium containing materials on rat lung. Br J Ind Med. 1986 Apr;43(4):243–256. doi: 10.1136/oem.43.4.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mancuso T. F. Chromium as an industrial carcinogen: Part I. Am J Ind Med. 1997 Feb;31(2):129–139. doi: 10.1002/(sici)1097-0274(199702)31:2<129::aid-ajim1>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  12. Moulin J. J., Portefaix P., Wild P., Mur J. M., Smagghe G., Mantout B. Mortality study among workers producing ferroalloys and stainless steel in France. Br J Ind Med. 1990 Aug;47(8):537–543. doi: 10.1136/oem.47.8.537. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Proctor D. M., Panko J. M., Finley B. L., Butler W. J., Barnhart R. J. Need for improved science in standard setting for hexavalent chromium. Regul Toxicol Pharmacol. 1999 Apr;29(2 Pt 1):99–101. doi: 10.1006/rtph.1998.1278. [DOI] [PubMed] [Google Scholar]
  14. Rosenman K. D., Stanbury M. Risk of lung cancer among former chromium smelter workers. Am J Ind Med. 1996 May;29(5):491–500. doi: 10.1002/(SICI)1097-0274(199605)29:5<491::AID-AJIM7>3.0.CO;2-P. [DOI] [PubMed] [Google Scholar]
  15. Sorahan T., Harrington J. M. Lung cancer in Yorkshire chrome platers, 1972-97. Occup Environ Med. 2000 Jun;57(6):385–389. doi: 10.1136/oem.57.6.385. [DOI] [PMC free article] [PubMed] [Google Scholar]

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