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. 2003 Jul;60(7):504–508. doi: 10.1136/oem.60.7.504

Geographical pattern of brain cancer incidence in the Navarre and Basque Country regions of Spain

G Lopez-Abente 1, M Pollan 1, E Ardanaz 1, M Errezola 1
PMCID: PMC1740573  PMID: 12819284

Abstract

Background: The study of the distribution of brain cancer mortality in Spain shows a grouping of highest risk provinces corresponding to the autonomous regions of Navarre and the Basque Country.

Aim: To explore the possible existence of geographical patterns in these areas.

Methods: Municipal maps of brain cancer incidence were drawn up and the influence of land use related variables on the distribution of the disease duly analysed. Autoregressive conditional models were used to plot smoothed municipal maps. The influence of explanatory land use variables, ascertained by remote sensing, was assessed.

Results: The maps revealed that certain towns situated in the "Media" and "Cantábrica-Baja Montaña" districts of Navarre were areas of highest risk. Among the towns in question, those in the "Media" district lie very close to the city of Pamplona. However, the pattern of brain cancer incidence in Navarre and the Basque Country could not be conclusively said to be determined by any specific type of land cover and/or crop.

Conclusions: Results suggest a possible increase of risk linked to areas devoted to a high percentage of non-irrigated arable land.

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Selected References

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  1. Barrett J. H., Parslow R. C., McKinney P. A., Law G. R., Forman D. Nitrate in drinking water and the incidence of gastric, esophageal, and brain cancer in Yorkshire, England. Cancer Causes Control. 1998 Mar;9(2):153–159. doi: 10.1023/a:1008878126535. [DOI] [PubMed] [Google Scholar]
  2. Bernardinelli L., Montomoli C. Empirical Bayes versus fully Bayesian analysis of geographical variation in disease risk. Stat Med. 1992 Jun 15;11(8):983–1007. doi: 10.1002/sim.4780110802. [DOI] [PubMed] [Google Scholar]
  3. Blair A., Malker H., Cantor K. P., Burmeister L., Wiklund K. Cancer among farmers. A review. Scand J Work Environ Health. 1985 Dec;11(6):397–407. doi: 10.5271/sjweh.2208. [DOI] [PubMed] [Google Scholar]
  4. Blot W. J., Henderson B. E., Boice J. D., Jr Childhood cancer in relation to cured meat intake: review of the epidemiological evidence. Nutr Cancer. 1999;34(1):111–118. doi: 10.1207/S15327914NC340115. [DOI] [PubMed] [Google Scholar]
  5. Bohnen N. I., Kurland L. T. Brain tumor and exposure to pesticides in humans: a review of the epidemiologic data. J Neurol Sci. 1995 Oct;132(2):110–121. doi: 10.1016/0022-510x(95)00151-q. [DOI] [PubMed] [Google Scholar]
  6. Cislaghi C., Biggeri A., Braga M., Lagazio C., Marchi M. Exploratory tools for disease mapping in geographical epidemiology. Stat Med. 1995 Nov 15;14(21-22):2363–2381. doi: 10.1002/sim.4780142108. [DOI] [PubMed] [Google Scholar]
  7. Clayton D. G., Bernardinelli L., Montomoli C. Spatial correlation in ecological analysis. Int J Epidemiol. 1993 Dec;22(6):1193–1202. doi: 10.1093/ije/22.6.1193. [DOI] [PubMed] [Google Scholar]
  8. Feychting M., Ahlbom A. Magnetic fields, leukemia, and central nervous system tumors in Swedish adults residing near high-voltage power lines. Epidemiology. 1994 Sep;5(5):501–509. [PubMed] [Google Scholar]
  9. Jarup Lars, Best Nicky, Toledano Mireille B., Wakefield Jon, Elliott Paul. Geographical epidemiology of prostate cancer in Great Britain. Int J Cancer. 2002 Feb 10;97(5):695–699. doi: 10.1002/ijc.10113. [DOI] [PubMed] [Google Scholar]
  10. Kaplan S., Novikov I., Modan B. Nutritional factors in the etiology of brain tumors: potential role of nitrosamines, fat, and cholesterol. Am J Epidemiol. 1997 Nov 15;146(10):832–841. doi: 10.1093/oxfordjournals.aje.a009201. [DOI] [PubMed] [Google Scholar]
  11. Kitron U., Kazmierczak J. J. Spatial analysis of the distribution of Lyme disease in Wisconsin. Am J Epidemiol. 1997 Mar 15;145(6):558–566. doi: 10.1093/oxfordjournals.aje.a009145. [DOI] [PubMed] [Google Scholar]
  12. Lagarde F., Pershagen G. Parallel analyses of individual and ecologic data on residential radon, cofactors, and lung cancer in Sweden. Am J Epidemiol. 1999 Feb 1;149(3):268–274. doi: 10.1093/oxfordjournals.aje.a009802. [DOI] [PubMed] [Google Scholar]
  13. McCredie M., Maisonneuve P., Boyle P. Antenatal risk factors for malignant brain tumours in New South Wales children. Int J Cancer. 1994 Jan 2;56(1):6–10. doi: 10.1002/ijc.2910560103. [DOI] [PubMed] [Google Scholar]
  14. Monson R. R., Fine L. J. Cancer mortality and morbidity among rubber workers. J Natl Cancer Inst. 1978 Oct;61(4):1047–1053. [PubMed] [Google Scholar]
  15. Morgenstern H. Ecologic studies in epidemiology: concepts, principles, and methods. Annu Rev Public Health. 1995;16:61–81. doi: 10.1146/annurev.pu.16.050195.000425. [DOI] [PubMed] [Google Scholar]
  16. Musicco M., Sant M., Molinari S., Filippini G., Gatta G., Berrino F. A case-control study of brain gliomas and occupational exposure to chemical carcinogens: the risk to farmers. Am J Epidemiol. 1988 Oct;128(4):778–785. doi: 10.1093/oxfordjournals.aje.a115031. [DOI] [PubMed] [Google Scholar]
  17. Pollán M., López-Abente G., Aragonés N., Ruiz M. Malignant brain tumour mortality among children and adolescents: geographical distribution in Spain. J Neurol Sci. 1999 Mar 1;163(2):127–136. doi: 10.1016/s0022-510x(99)00010-6. [DOI] [PubMed] [Google Scholar]
  18. Preston-Martin S. Epidemiology of primary CNS neoplasms. Neurol Clin. 1996 May;14(2):273–290. doi: 10.1016/s0733-8619(05)70256-5. [DOI] [PubMed] [Google Scholar]
  19. Preston-Martin S., Pogoda J. M., Mueller B. A., Holly E. A., Lijinsky W., Davis R. L. Maternal consumption of cured meats and vitamins in relation to pediatric brain tumors. Cancer Epidemiol Biomarkers Prev. 1996 Aug;5(8):599–605. [PubMed] [Google Scholar]
  20. Richardson S., Stücker I., Hémon D. Comparison of relative risks obtained in ecological and individual studies: some methodological considerations. Int J Epidemiol. 1987 Mar;16(1):111–120. doi: 10.1093/ije/16.1.111. [DOI] [PubMed] [Google Scholar]
  21. Steindorf K., Schlehofer B., Becher H., Hornig G., Wahrendorf J. Nitrate in drinking water. A case-control study on primary brain tumours with an embedded drinking water survey in Germany. Int J Epidemiol. 1994 Jun;23(3):451–457. doi: 10.1093/ije/23.3.451. [DOI] [PubMed] [Google Scholar]
  22. Viel J. F., Challier B., Pitard A., Pobel D. Brain cancer mortality among French farmers: the vineyard pesticide hypothesis. Arch Environ Health. 1998 Jan-Feb;53(1):65–70. doi: 10.1080/00039899809605690. [DOI] [PubMed] [Google Scholar]
  23. Waxweiler R. J., Alexander V., Leffingwell S. S., Haring M., Lloyd J. W. Mortality from brain tumor and other causes in a cohort of petrochemical workers. J Natl Cancer Inst. 1983 Jan;70(1):75–81. [PubMed] [Google Scholar]

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