Skip to main content
PMC home page
Occupational and Environmental Medicine logoLink to Occupational and Environmental Medicine
. 2003 Aug;60(8):612–616. doi: 10.1136/oem.60.8.612

Oxidative stress: its role in air pollution and adverse health effects

F Kelly 1
PMCID: PMC1740593  PMID: 12883027

Full Text

The Full Text of this article is available as a PDF (115.0 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown D. M., Stone V., Findlay P., MacNee W., Donaldson K. Increased inflammation and intracellular calcium caused by ultrafine carbon black is independent of transition metals or other soluble components. Occup Environ Med. 2000 Oct;57(10):685–691. doi: 10.1136/oem.57.10.685. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Brown R. K., Kelly F. J. Role of free radicals in the pathogenesis of cystic fibrosis. Thorax. 1994 Aug;49(8):738–742. doi: 10.1136/thx.49.8.738. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Costa D. L., Dreher K. L. Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. Environ Health Perspect. 1997 Sep;105 (Suppl 5):1053–1060. doi: 10.1289/ehp.97105s51053. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Forman Henry Jay, Torres Martine, Fukuto Jon. Redox signaling. Mol Cell Biochem. 2002 May-Jun;234-235(1-2):49–62. [PubMed] [Google Scholar]
  5. Frampton M. W., Pryor W. A., Cueto R., Cox C., Morrow P. E., Utell M. J. Ozone exposure increases aldehydes in epithelial lining fluid in human lung. Am J Respir Crit Care Med. 1999 Apr;159(4 Pt 1):1134–1137. doi: 10.1164/ajrccm.159.4.9807057. [DOI] [PubMed] [Google Scholar]
  6. Hatch G. E., Slade R., Harris L. P., McDonnell W. F., Devlin R. B., Koren H. S., Costa D. L., McKee J. Ozone dose and effect in humans and rats. A comparison using oxygen-18 labeling and bronchoalveolar lavage. Am J Respir Crit Care Med. 1994 Sep;150(3):676–683. doi: 10.1164/ajrccm.150.3.8087337. [DOI] [PubMed] [Google Scholar]
  7. Kadiiska M. B., Mason R. P., Dreher K. L., Costa D. L., Ghio A. J. In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle. Chem Res Toxicol. 1997 Oct;10(10):1104–1108. doi: 10.1021/tx970049r. [DOI] [PubMed] [Google Scholar]
  8. Kelly F. J., Mudway I., Blomberg A., Frew A., Sandström T. Altered lung antioxidant status in patients with mild asthma. Lancet. 1999 Aug 7;354(9177):482–483. doi: 10.1016/S0140-6736(99)01812-7. [DOI] [PubMed] [Google Scholar]
  9. Kelly F. J., Mudway I., Krishna M. T., Holgate S. T. The free radical basis of air pollution: focus on ozone. Respir Med. 1995 Nov;89(10):647–656. doi: 10.1016/0954-6111(95)90131-0. [DOI] [PubMed] [Google Scholar]
  10. Kelly F. J., Tetley T. D. Nitrogen dioxide depletes uric acid and ascorbic acid but not glutathione from lung lining fluid. Biochem J. 1997 Jul 1;325(Pt 1):95–99. doi: 10.1042/bj3250095. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Langford S. D., Bidani A., Postlethwait E. M. Ozone-reactive absorption by pulmonary epithelial lining fluid constituents. Toxicol Appl Pharmacol. 1995 May;132(1):122–130. doi: 10.1006/taap.1995.1093. [DOI] [PubMed] [Google Scholar]
  12. Li X. Y., Gilmour P. S., Donaldson K., MacNee W. Free radical activity and pro-inflammatory effects of particulate air pollution (PM10) in vivo and in vitro. Thorax. 1996 Dec;51(12):1216–1222. doi: 10.1136/thx.51.12.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Mudway I. S., Kelly F. J. Modeling the interactions of ozone with pulmonary epithelial lining fluid antioxidants. Toxicol Appl Pharmacol. 1998 Jan;148(1):91–100. doi: 10.1006/taap.1997.8318. [DOI] [PubMed] [Google Scholar]
  14. Mudway I. S., Kelly F. J. Ozone and the lung: a sensitive issue. Mol Aspects Med. 2000 Feb-Apr;21(1-2):1–48. doi: 10.1016/s0098-2997(00)00003-0. [DOI] [PubMed] [Google Scholar]
  15. Mudway I. S., Stenfors N., Blomberg A., Helleday R., Dunster C., Marklund S. L., Frew A. J., Sandström T., Kelly F. J. Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: a comparison of healthy and mild asthmatic subjects. Free Radic Biol Med. 2001 Oct 15;31(8):962–974. doi: 10.1016/s0891-5849(01)00671-2. [DOI] [PubMed] [Google Scholar]
  16. Oury T. D., Chang L. Y., Marklund S. L., Day B. J., Crapo J. D. Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab Invest. 1994 Jun;70(6):889–898. [PubMed] [Google Scholar]
  17. Samet J. M., Dominici F., Curriero F. C., Coursac I., Zeger S. L. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med. 2000 Dec 14;343(24):1742–1749. doi: 10.1056/NEJM200012143432401. [DOI] [PubMed] [Google Scholar]
  18. Sandström T., Stjernberg N., Eklund A., Ledin M. C., Bjermer L., Kolmodin-Hedman B., Lindström K., Rosenhall L., Angström T. Inflammatory cell response in bronchoalveolar lavage fluid after nitrogen dioxide exposure of healthy subjects: a dose-response study. Eur Respir J. 1991 Mar;4(3):332–339. [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

[Web-only References]
oenvmed_60_8_612__index.html (1KB, html)
oenvmed_60_8_612__1.pdf (96.5KB, pdf)

Articles from Occupational and Environmental Medicine are provided here courtesy of BMJ Publishing Group

RESOURCES