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. 2004 Apr;61(4):325–333. doi: 10.1136/oem.2002.005561

Temporal association between serum prolactin concentration and exposure to styrene

U Luderer 1, R Tornero-Velez 1, T Shay 1, S Rappaport 1, N Heyer 1, D Echeverria 1
PMCID: PMC1740755  PMID: 15031390

Abstract

Background: Previous studies have suggested that occupational exposure to styrene is associated with increased serum levels of the anterior pituitary hormone prolactin (PRL).

Aims: To test the hypotheses that: (1) the effect of styrene exposure on PRL secretion is an acute effect, not a subchronic or chronic effect; (2) blood styrene, as a measure of absorbed dose, is a stronger predictor of serum PRL level than personal breathing zone air styrene concentration.

Methods: Subjects were recruited from 17 workplaces in the reinforced plastics industry. Personal breathing zone air styrene, whole blood styrene, and serum PRL were measured during one to three sessions, approximately one year apart. Linear multiple regression was used to model the relations between acute (air styrene or blood styrene obtained at same time as PRL), subchronic (average air or blood styrene over two or three sessions), and chronic (years of work in industry or facility times average air styrene over all sessions) indices of styrene exposure and serum PRL.

Results: Acute blood styrene concentration was the strongest predictor of serum PRL concentration, with the model predicting a 2.06-fold increase in PRL (95% CI 1.11 to 3.84) for every 10-fold increase in blood styrene. Serum PRL tended to increase with increasing styrene exposure in both men and women; however, women tended to have higher PRL levels. For women, the change in blood styrene between sessions 1 and 2 was a significant predictor of the change in serum PRL between sessions.

Conclusions: Results confirm that styrene exposure enhances serum PRL concentrations and support an acute effect of styrene on PRL secretion.

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Selected References

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  1. Apostoli P., Alessandro G., Placidi D., Alessio L. Metabolic interferences in subjects occupationally exposed to binary styrene-acetone mixtures. Int Arch Occup Environ Health. 1998 Oct;71(7):445–452. doi: 10.1007/s004200050304. [DOI] [PubMed] [Google Scholar]
  2. Arfini G., Mutti A., Vescovi P., Ferroni C., Ferrari M., Giaroli C., Passeri M., Franchini I. Impaired dopaminergic modulation of pituitary secretion in workers occupationally exposed to styrene: further evidence from PRL response to TRH stimulation. J Occup Med. 1987 Oct;29(10):826–830. [PubMed] [Google Scholar]
  3. Ben-Jonathan N., Mershon J. L., Allen D. L., Steinmetz R. W. Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects. Endocr Rev. 1996 Dec;17(6):639–669. doi: 10.1210/edrv-17-6-639. [DOI] [PubMed] [Google Scholar]
  4. Bergamaschi E., Mutti A., Cavazzini S., Vettori M. V., Renzulli F. S., Franchini I. Peripheral markers of neurochemical effects among styrene-exposed workers. Neurotoxicology. 1996 Fall-Winter;17(3-4):753–759. [PubMed] [Google Scholar]
  5. Bergamaschi E., Smargiassi A., Mutti A., Cavazzini S., Vettori M. V., Alinovi R., Franchini I., Mergler D. Peripheral markers of catecholaminergic dysfunction and symptoms of neurotoxicity among styrene-exposed workers. Int Arch Occup Environ Health. 1997;69(3):209–214. doi: 10.1007/s004200050138. [DOI] [PubMed] [Google Scholar]
  6. Blackman M. R. Pituitary hormones and aging. Endocrinol Metab Clin North Am. 1987 Dec;16(4):981–994. [PubMed] [Google Scholar]
  7. Campagna D., Mergler D., Huel G., Bélanger S., Truchon G., Ostiguy C., Drolet D. Visual dysfunction among styrene-exposed workers. Scand J Work Environ Health. 1995 Oct;21(5):382–390. doi: 10.5271/sjweh.53. [DOI] [PubMed] [Google Scholar]
  8. Chakrabarti S. K. Altered regulation of dopaminergic activity and impairment in motor function in rats after subchronic exposure to styrene. Pharmacol Biochem Behav. 2000 Jul;66(3):523–532. doi: 10.1016/s0091-3057(00)00216-1. [DOI] [PubMed] [Google Scholar]
  9. Cherry N., Rodgers B., Venables H., Waldron H. A., Wells G. G. Acute behavioral effects of styrene exposure: a further analysis. Br J Ind Med. 1981 Nov;38(4):346–350. doi: 10.1136/oem.38.4.346. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Cherry N., Waldron H. A., Wells G. G., Wilkinson R. T., Wilson H. K., Jones S. An investigation of the acute behavioural effects of styrene on factory workers. Br J Ind Med. 1980 Aug;37(3):234–240. doi: 10.1136/oem.37.3.234. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fuxe K., Andersson K., Eneroth P., Härfstrand A., Agnati L. F. Neuroendocrine actions of nicotine and of exposure to cigarette smoke: medical implications. Psychoneuroendocrinology. 1989;14(1-2):19–41. doi: 10.1016/0306-4530(89)90054-1. [DOI] [PubMed] [Google Scholar]
  12. Gobba F., Galassi C., Imbriani M., Ghittori S., Candela S., Cavalleri A. Acquired dyschromatopsia among styrene-exposed workers. J Occup Med. 1991 Jul;33(7):761–765. [PubMed] [Google Scholar]
  13. Guillemin M. P., Berode M. Biological monitoring of styrene: a review. Am Ind Hyg Assoc J. 1988 Oct;49(10):497–505. doi: 10.1080/15298668891380123. [DOI] [PubMed] [Google Scholar]
  14. Jang J. Y., Droz P. O., Berode M. Ethnic differences in biological monitoring of several organic solvents. I. Human exposure experiment. Int Arch Occup Environ Health. 1997;69(5):343–349. doi: 10.1007/s004200050158. [DOI] [PubMed] [Google Scholar]
  15. Letz R., Mahoney F. C., Hershman D. L., Woskie S., Smith T. J. Neurobehavioral effects of acute styrene exposure in fiberglass boatbuilders. Neurotoxicol Teratol. 1990 Nov-Dec;12(6):665–668. doi: 10.1016/0892-0362(90)90083-o. [DOI] [PubMed] [Google Scholar]
  16. Maddox P. R., Jones D. L., Mansel R. E. Basal prolactin and total lactogenic hormone levels by microbioassay and immunoassay in normal human sera. Acta Endocrinol (Copenh) 1991 Dec;125(6):621–627. doi: 10.1530/acta.0.1250621. [DOI] [PubMed] [Google Scholar]
  17. Mutti A., Falzoi M., Romanelli A., Franchini I. Regional alterations of brain catecholamines by styrene exposure in rabbits. Arch Toxicol. 1984 Sep;55(3):173–177. doi: 10.1007/BF00316123. [DOI] [PubMed] [Google Scholar]
  18. Mutti A., Mazzucchi A., Rustichelli P., Frigeri G., Arfini G., Franchini I. Exposure-effect and exposure-response relationships between occupational exposure to styrene and neuropsychological functions. Am J Ind Med. 1984;5(4):275–286. doi: 10.1002/ajim.4700050404. [DOI] [PubMed] [Google Scholar]
  19. Mutti A., Romanelli A., Falzoi M., Lucertini S., Franchini I. Styrene metabolism and striatal dopamine depletion in rabbits. Arch Toxicol Suppl. 1985;8:447–450. doi: 10.1007/978-3-642-69928-3_101. [DOI] [PubMed] [Google Scholar]
  20. Mutti A., Vescovi P. P., Falzoi M., Arfini G., Valenti G., Franchini I. Neuroendocrine effects of styrene on occupationally exposed workers. Scand J Work Environ Health. 1984 Aug;10(4):225–228. doi: 10.5271/sjweh.2340. [DOI] [PubMed] [Google Scholar]
  21. Shimon I., Melmed S. Management of pituitary tumors. Ann Intern Med. 1998 Sep 15;129(6):472–483. doi: 10.7326/0003-4819-129-6-199809150-00009. [DOI] [PubMed] [Google Scholar]
  22. Stoker T. E., Robinette C. L., Cooper R. L. Maternal exposure to atrazine during lactation suppresses suckling-induced prolactin release and results in prostatitis in the adult offspring. Toxicol Sci. 1999 Nov;52(1):68–79. doi: 10.1093/toxsci/52.1.68. [DOI] [PubMed] [Google Scholar]
  23. Tangbanluekal L., Robinette C. L. Prolactin mediates estradiol-induced inflammation in the lateral prostate of Wistar rats. Endocrinology. 1993 Jun;132(6):2407–2416. doi: 10.1210/endo.132.6.8504745. [DOI] [PubMed] [Google Scholar]
  24. Tornero-Velez R., Waidyanatha S., Pérez H. L., Osterman-Golkar S., Echeverria D., Rappaport S. M. Determination of styrene and styrene-7,8-oxide in human blood by gas chromatography-mass spectrometry. J Chromatogr B Biomed Sci Appl. 2001 Jun 5;757(1):59–68. doi: 10.1016/s0378-4347(01)00063-9. [DOI] [PubMed] [Google Scholar]
  25. Triebig G., Lehrl S., Weltle D., Schaller K. H., Valentin H. Clinical and neurobehavioural study of the acute and chronic neurotoxicity of styrene. Br J Ind Med. 1989 Nov;46(11):799–804. doi: 10.1136/oem.46.11.799. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Triebig G., Stark T., Ihrig A., Dietz M. C. Intervention study on acquired color vision deficiencies in styrene-exposed workers. J Occup Environ Med. 2001 May;43(5):494–500. doi: 10.1097/00043764-200105000-00010. [DOI] [PubMed] [Google Scholar]
  27. Yokoyama K., Araki S., Murata K. Effects of low level styrene exposure on psychological performance in FRP boat laminating workers. Neurotoxicology. 1992 Fall;13(3):551–556. [PubMed] [Google Scholar]
  28. van Coevorden A., Mockel J., Laurent E., Kerkhofs M., L'Hermite-Balériaux M., Decoster C., Nève P., Van Cauter E. Neuroendocrine rhythms and sleep in aging men. Am J Physiol. 1991 Apr;260(4 Pt 1):E651–E661. doi: 10.1152/ajpendo.1991.260.4.E651. [DOI] [PubMed] [Google Scholar]

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