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. 1996 Jun;64(6):2362–2364. doi: 10.1128/iai.64.6.2362-2364.1996

New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae.

T M Silva 1, M A Schleupner 1, C O Tacket 1, T S Steiner 1, J B Kaper 1, R Edelman 1, R Guerrant 1
PMCID: PMC174082  PMID: 8675353

Abstract

Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and 0139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent 0139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved.

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Selected References

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