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. 2005 May;62(5):290–299. doi: 10.1136/oem.2004.016287

Evidence based guidelines for the prevention, identification, and management of occupational asthma

P Nicholson 1, P Cullinan 1, T Newman 1, P Burge 1, C Boyle 1
PMCID: PMC1741012  PMID: 15837849

Abstract

Background: Occupational asthma is the most frequently reported work related respiratory disease in many countries. This work was commissioned by the British Occupational Health Research Foundation to assist the Health and Safety Executive in achieving its target of reducing the incidence of occupational asthma in Great Britain by 30% by 2010.

Aim: The guidelines aim to improve the prevention, identification, and management of occupational asthma by providing evidence based recommendations on which future practice can be based.

Methods: The literature was searched systematically using Medline and Embase for articles published in all languages up to the end of June 2004. Evidence based statements and recommendations were graded according to the Royal College of General Practitioner's star system and the revised Scottish Intercollegiate Guidelines Network grading system.

Results: A total of 474 original studies were selected for appraisal from over 2500 abstracts. The systematic review produced 52 graded evidence statements and 22 recommendations based on 223 studies.

Discussion: Evidence based guidelines have become benchmarks for practice in healthcare and the process used to prepare them is well established. This evidence review and its recommendations focus on interventions and outcomes to provide a robust approach to the prevention, identification, and management of occupational asthma, based on and using the best available medical evidence. The most important action to prevent cases of occupational asthma is to reduce exposure at source. Thereafter surveillance should be performed for the early identification of symptoms, including occupational rhinitis, with additional functional and immunological tests where appropriate. Effective management of workers suspected to have occupational asthma involves the identification and investigation of symptoms suggestive of asthma immediately they occur. Those workers who are confirmed to have occupational asthma should be advised to avoid further exposure completely and early in the course of their disease to offer the best chance of recovery.

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Selected References

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  1. Agrup G., Belin L., Sjöstedt L., Skerfving S. Allergy to laboratory animals in laboratory technicians and animal keepers. Br J Ind Med. 1986 Mar;43(3):192–198. doi: 10.1136/oem.43.3.192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Allard C., Cartier A., Ghezzo H., Malo J. L. Occupational asthma due to various agents. Absence of clinical and functional improvement at an interval of four or more years after cessation of exposure. Chest. 1989 Nov;96(5):1046–1049. doi: 10.1378/chest.96.5.1046. [DOI] [PubMed] [Google Scholar]
  3. Allmers Henning, Schmengler Jörg, Skudlik Christoph. Primary prevention of natural rubber latex allergy in the German health care system through education and intervention. J Allergy Clin Immunol. 2002 Aug;110(2):318–323. doi: 10.1067/mai.2002.126461. [DOI] [PubMed] [Google Scholar]
  4. Ameille J., Pairon J. C., Bayeux M. C., Brochard P., Choudat D., Conso F., Devienne A., Garnier R., Iwatsubo Y. Consequences of occupational asthma on employment and financial status: a follow-up study. Eur Respir J. 1997 Jan;10(1):55–58. doi: 10.1183/09031936.97.10010055. [DOI] [PubMed] [Google Scholar]
  5. Ameille J., Pauli G., Calastreng-Crinquand A., Vervloët D., Iwatsubo Y., Popin E., Bayeux-Dunglas M. C., Kopferschmitt-Kubler M. C., Observatoire National des Asthmes Professionnels Reported incidence of occupational asthma in France, 1996-99: the ONAP programme. Occup Environ Med. 2003 Feb;60(2):136–141. doi: 10.1136/oem.60.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Anees W., Huggins V., Pavord I. D., Robertson A. S., Burge P. S. Occupational asthma due to low molecular weight agents: eosinophilic and non-eosinophilic variants. Thorax. 2002 Mar;57(3):231–236. doi: 10.1136/thorax.57.3.231. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Axon E. J., Beach J. R., Burge P. S. A comparison of some of the characteristics of patients with occupational and non-occupational asthma. Occup Med (Lond) 1995 Apr;45(2):109–111. doi: 10.1093/occmed/45.2.109. [DOI] [PubMed] [Google Scholar]
  8. Baker D. B., Gann P. H., Brooks S. M., Gallagher J., Bernstein I. L. Cross-sectional study of platinum salts sensitization among precious metals refinery workers. Am J Ind Med. 1990;18(6):653–664. doi: 10.1002/ajim.4700180604. [DOI] [PubMed] [Google Scholar]
  9. Balboni A., Baricordi O. R., Fabbri L. M., Gandini E., Ciaccia A., Mapp C. E. Association between toluene diisocyanate-induced asthma and DQB1 markers: a possible role for aspartic acid at position 57. Eur Respir J. 1996 Feb;9(2):207–210. doi: 10.1183/09031936.96.09020207. [DOI] [PubMed] [Google Scholar]
  10. Baldwin D. R., Gannon P., Bright P., Newton D. T., Robertson A., Venables K., Graneek B., Barker R. D., Cartier A., Malo J-L. Interpretation of occupational peak flow records: level of agreement between expert clinicians and Oasys-2. Thorax. 2002 Oct;57(10):860–864. doi: 10.1136/thorax.57.10.860. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Balmes John, Becklake Margaret, Blanc Paul, Henneberger Paul, Kreiss Kathleen, Mapp Cristina, Milton Donald, Schwartz David, Toren Kjell, Viegi Giovanni. American Thoracic Society Statement: Occupational contribution to the burden of airway disease. Am J Respir Crit Care Med. 2003 Mar 1;167(5):787–797. doi: 10.1164/rccm.167.5.787. [DOI] [PubMed] [Google Scholar]
  12. Bar-Sela S., Teichtahl H., Lutsky I. Occupational asthma in poultry workers. J Allergy Clin Immunol. 1984 Feb;73(2):271–275. doi: 10.1016/s0091-6749(84)80019-6. [DOI] [PubMed] [Google Scholar]
  13. Barker R. D., Harris J. M., Welch J. A., Venables K. M., Newman Taylor A. J. Occupational asthma caused by tetrachlorophthalic anhydride: a 12-year follow-up. J Allergy Clin Immunol. 1998 Jun;101(6 Pt 1):717–719. doi: 10.1016/s0091-6749(98)70401-4. [DOI] [PubMed] [Google Scholar]
  14. Baur X., Czuppon A. Diagnostic validation of specific IgE antibody concentrations, skin prick testing, and challenge tests in chemical workers with symptoms of sensitivity to different anhydrides. J Allergy Clin Immunol. 1995 Oct;96(4):489–494. doi: 10.1016/s0091-6749(95)70292-x. [DOI] [PubMed] [Google Scholar]
  15. Baur X., Degens P. O., Sander I. Baker's asthma: still among the most frequent occupational respiratory disorders. J Allergy Clin Immunol. 1998 Dec;102(6 Pt 1):984–997. doi: 10.1016/s0091-6749(98)70337-9. [DOI] [PubMed] [Google Scholar]
  16. Baur X., Huber H., Degens P. O., Allmers H., Ammon J. Relation between occupational asthma case history, bronchial methacholine challenge, and specific challenge test in patients with suspected occupational asthma. Am J Ind Med. 1998 Feb;33(2):114–122. doi: 10.1002/(sici)1097-0274(199802)33:2<114::aid-ajim3>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  17. Beghé B., Padoan M., Moss C. T., Barton S. J., Holloway J. W., Holgate S. T., Howell W. M., Mapp C. E. Lack of association of HLA class I genes and TNF alpha-308 polymorphism in toluene diisocyanate-induced asthma. Allergy. 2004 Jan;59(1):61–64. doi: 10.1046/j.1398-9995.2003.00352.x. [DOI] [PubMed] [Google Scholar]
  18. Bernstein D. I., Korbee L., Stauder T., Bernstein J. A., Scinto J., Herd Z. L., Bernstein I. L. The low prevalence of occupational asthma and antibody-dependent sensitization to diphenylmethane diisocyanate in a plant engineered for minimal exposure to diisocyanates. J Allergy Clin Immunol. 1993 Sep;92(3):387–396. doi: 10.1016/0091-6749(93)90117-x. [DOI] [PubMed] [Google Scholar]
  19. Bernstein David I., Karnani Ravi, Biagini Ray E., Bernstein Cheryl K., Murphy Karen, Berendts Brian, Bernstein Jonathan A., Bernstein Leonard. Clinical and occupational outcomes in health care workers with natural rubber latex allergy. Ann Allergy Asthma Immunol. 2003 Feb;90(2):209–213. doi: 10.1016/s1081-1206(10)62143-6. [DOI] [PubMed] [Google Scholar]
  20. Bernstein J. A., Munson J., Lummus Z. L., Balakrishnan K., Leikauf G. T-cell receptor V beta gene segment expression in diisocyanate-induced occupational asthma. J Allergy Clin Immunol. 1997 Feb;99(2):245–250. doi: 10.1016/s0091-6749(97)70104-0. [DOI] [PubMed] [Google Scholar]
  21. Bignon J. S., Aron Y., Ju L. Y., Kopferschmitt M. C., Garnier R., Mapp C., Fabbri L. M., Pauli G., Lockhart A., Charron D. HLA class II alleles in isocyanate-induced asthma. Am J Respir Crit Care Med. 1994 Jan;149(1):71–75. doi: 10.1164/ajrccm.149.1.8111601. [DOI] [PubMed] [Google Scholar]
  22. Blanc P. D., Toren K. How much adult asthma can be attributed to occupational factors? Am J Med. 1999 Dec;107(6):580–587. doi: 10.1016/s0002-9343(99)00307-1. [DOI] [PubMed] [Google Scholar]
  23. Botham P. A., Davies G. E., Teasdale E. L. Allergy to laboratory animals: a prospective study of its incidence and of the influence of atopy on its development. Br J Ind Med. 1987 Sep;44(9):627–632. doi: 10.1136/oem.44.9.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Brhel Petr. Occupational respiratory diseases in the Czech Republic. Ind Health. 2003 Apr;41(2):121–123. doi: 10.2486/indhealth.41.121. [DOI] [PubMed] [Google Scholar]
  25. Bright P., Newton D. T., Gannon P. F., Pantin C. F., Burge P. S. OASYS-3: improved analysis of serial peak expiratory flow in suspected occupational asthma. Monaldi Arch Chest Dis. 2001 Jun;56(3):281–288. [PubMed] [Google Scholar]
  26. Brisman J., Järvholm B., Lillienberg L. Exposure-response relations for self reported asthma and rhinitis in bakers. Occup Environ Med. 2000 May;57(5):335–340. doi: 10.1136/oem.57.5.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Brisman Jonas, Lillienberg Linnéa, Belin Lars, Ahman Mats, Järvholm Bengt. Sensitisation to occupational allergens in bakers' asthma and rhinitis: a case-referent study. Int Arch Occup Environ Health. 2002 Nov 1;76(2):167–170. doi: 10.1007/s00420-002-0396-3. [DOI] [PubMed] [Google Scholar]
  28. Burge P. S., Edge G., Hawkins R., White V., Taylor A. J. Occupational asthma in a factory making flux-cored solder containing colophony. Thorax. 1981 Nov;36(11):828–834. doi: 10.1136/thx.36.11.828. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Burge P. S. Non-specific bronchial hyper-reactivity in workers exposed to toluene di-isocyanate, diphenyl methane di-isocyanate and colophony. Eur J Respir Dis Suppl. 1982;123:91–96. [PubMed] [Google Scholar]
  30. Burge P. S., O'Brien I. M., Harries M. G. Peak flow rate records in the diagnosis of occupational asthma due to colophony. Thorax. 1979 Jun;34(3):308–316. doi: 10.1136/thx.34.3.308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Burge P. S., O'Brien I. M., Harries M. G. Peak flow rate records in the diagnosis of occupational asthma due to isocyanates. Thorax. 1979 Jun;34(3):317–323. doi: 10.1136/thx.34.3.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  32. Burge P. S. Occupational asthma in electronics workers caused by colophony fumes: follow-up of affected workers. Thorax. 1982 May;37(5):348–353. doi: 10.1136/thx.37.5.348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Butcher B. T., Jones R. N., O'Neil C. E., Glindmeyer H. W., Diem J. E., Dharmarajan V., Weill H., Salvaggio J. E. Longitudinal study of workers employed in the manufacture of toluene-diisocyanate. Am Rev Respir Dis. 1977 Sep;116(3):411–421. doi: 10.1164/arrd.1977.116.3.411. [DOI] [PubMed] [Google Scholar]
  34. Calverley A. E., Rees D., Dowdeswell R. J., Linnett P. J., Kielkowski D. Platinum salt sensitivity in refinery workers: incidence and effects of smoking and exposure. Occup Environ Med. 1995 Oct;52(10):661–666. doi: 10.1136/oem.52.10.661. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Cannon J., Cullinan P., Newman Taylor A. Consequences of occupational asthma. BMJ. 1995 Sep 2;311(7005):602–603. doi: 10.1136/bmj.311.7005.602. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Cartier A., Grammer L., Malo J. L., Lagier F., Ghezzo H., Harris K., Patterson R. Specific serum antibodies against isocyanates: association with occupational asthma. J Allergy Clin Immunol. 1989 Oct;84(4 Pt 1):507–514. doi: 10.1016/0091-6749(89)90364-3. [DOI] [PubMed] [Google Scholar]
  37. Cartier A., Malo J. L., Forest F., Lafrance M., Pineau L., St-Aubin J. J., Dubois J. Y. Occupational asthma in snow crab-processing workers. J Allergy Clin Immunol. 1984 Sep;74(3 Pt 1):261–269. doi: 10.1016/0091-6749(84)90256-2. [DOI] [PubMed] [Google Scholar]
  38. Cathcart M., Nicholson P., Roberts D., Bazley M., Juniper C., Murray P., Randell M. Enzyme exposure, smoking and lung function in employees in the detergent industry over 20 years. Medical Subcommittee of the UK Soap and Detergent Industry Association. Occup Med (Lond) 1997 Nov;47(8):473–478. doi: 10.1093/occmed/47.8.473. [DOI] [PubMed] [Google Scholar]
  39. Chan-Yeung M., Lam S., Koener S. Clinical features and natural history of occupational asthma due to western red cedar (Thuja plicata). Am J Med. 1982 Mar;72(3):411–415. doi: 10.1016/0002-9343(82)90497-1. [DOI] [PubMed] [Google Scholar]
  40. Chan-Yeung M., MacLean L., Paggiaro P. L. Follow-up study of 232 patients with occupational asthma caused by western red cedar (Thuja plicata). J Allergy Clin Immunol. 1987 May;79(5):792–796. doi: 10.1016/0091-6749(87)90212-0. [DOI] [PubMed] [Google Scholar]
  41. Chatkin J. M., Tarlo S. M., Liss G., Banks D., Broder I. The outcome of asthma related to workplace irritant exposures: a comparison of irritant-induced asthma and irritant aggravation of asthma. Chest. 1999 Dec;116(6):1780–1785. doi: 10.1378/chest.116.6.1780. [DOI] [PubMed] [Google Scholar]
  42. Cockcroft A., Edwards J., McCarthy P., Andersson N. Allergy in laboratory animal workers. Lancet. 1981 Apr 11;1(8224):827–830. doi: 10.1016/s0140-6736(81)92693-3. [DOI] [PubMed] [Google Scholar]
  43. Colt H. G., Beamis J. J., Harrell J. H., Mathur P. M. Novel flexible bronchoscope and single-use disposable-sheath endoscope system. A preliminary technology evaluation. Chest. 2000 Jul;118(1):183–187. doi: 10.1378/chest.118.1.183. [DOI] [PubMed] [Google Scholar]
  44. Cortona G., Pisati G., Dellabianca A., Moscato G. Allergopatie professionali respiratorie: l'esperienza delle Unità Operative Ospedaliere di Medicina del Lavoro in Lombardia dal 1990 al 1998. G Ital Med Lav Ergon. 2001 Jan-Mar;23(1):64–70. [PubMed] [Google Scholar]
  45. Coutts I. L., Lozewicz S., Dally M. B., Newman-Taylor A. J., Burge P. S., Flind A. C., Rogers D. J. Respiratory symptoms related to work in a factory manufacturing cimetidine tablets. Br Med J (Clin Res Ed) 1984 May 12;288(6428):1418–1418. doi: 10.1136/bmj.288.6428.1418. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Cullen M. R., Redlich C. A., Beckett W. S., Weltmann B., Sparer J., Jackson G., Ruff T., Rubinstein E., Holden W. Feasibility study of respiratory questionnaire and peak flow recordings in autobody shop workers exposed to isocyanate-containing spray paint: observations and limitations. Occup Med (Lond) 1996 Jun;46(3):197–204. doi: 10.1093/occmed/46.3.197. [DOI] [PubMed] [Google Scholar]
  47. Cullinan P., Cook A., Gordon S., Nieuwenhuijsen M. J., Tee R. D., Venables K. M., McDonald J. C., Taylor A. J. Allergen exposure, atopy and smoking as determinants of allergy to rats in a cohort of laboratory employees. Eur Respir J. 1999 May;13(5):1139–1143. doi: 10.1034/j.1399-3003.1999.13e33.x. [DOI] [PubMed] [Google Scholar]
  48. Cullinan P., Cook A., Nieuwenhuijsen M. J., Sandiford C., Tee R. D., Venables K. M., McDonald J. C., Newman Taylor A. J. Allergen and dust exposure as determinants of work-related symptoms and sensitization in a cohort of flour-exposed workers; a case-control analysis. Ann Occup Hyg. 2001 Mar;45(2):97–103. doi: 10.1016/s0003-4878(00)00028-4. [DOI] [PubMed] [Google Scholar]
  49. Cullinan P., Harris J. M., Newman Taylor A. J., Hole A. M., Jones M., Barnes F., Jolliffe G. An outbreak of asthma in a modern detergent factory. Lancet. 2000 Dec 2;356(9245):1899–1900. doi: 10.1016/s0140-6736(00)03264-5. [DOI] [PubMed] [Google Scholar]
  50. Cullinan P., Lowson D., Nieuwenhuijsen M. J., Sandiford C., Tee R. D., Venables K. M., McDonald J. C., Newman Taylor A. J. Work related symptoms, sensitisation, and estimated exposure in workers not previously exposed to flour. Occup Environ Med. 1994 Sep;51(9):579–583. doi: 10.1136/oem.51.9.579. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Côté J., Kennedy S., Chan-Yeung M. Quantitative versus qualitative analysis of peak expiratory flow in occupational asthma. Thorax. 1993 Jan;48(1):48–51. doi: 10.1136/thx.48.1.48. [DOI] [PMC free article] [PubMed] [Google Scholar]
  52. Côté J., Kennedy S., Chan-Yeung M. Sensitivity and specificity of PC20 and peak expiratory flow rate in cedar asthma. J Allergy Clin Immunol. 1990 Mar;85(3):592–598. doi: 10.1016/0091-6749(90)90098-o. [DOI] [PubMed] [Google Scholar]
  53. De Zotti R., Bovenzi M., Molinari S., Larese F., Peresson M. Sintomi respiratori e sensibilizzazioni professionali in un gruppo di allievi panificatori: risultati di un follow-up a 6 mesi. Med Lav. 1997 Mar-Apr;88(2):155–165. [PubMed] [Google Scholar]
  54. De Zotti R., Bovenzi M. Prospective study of work related respiratory symptoms in trainee bakers. Occup Environ Med. 2000 Jan;57(1):58–61. doi: 10.1136/oem.57.1.58. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. De Zotti R., Larese F., Bovenzi M., Negro C., Molinari S. Allergic airway disease in Italian bakers and pastry makers. Occup Environ Med. 1994 Aug;51(8):548–552. doi: 10.1136/oem.51.8.548. [DOI] [PMC free article] [PubMed] [Google Scholar]
  56. Di Stefano F., Siriruttanapruk S., McCoach J., Burge P. S. Glutaraldehyde: an occupational hazard in the hospital setting. Allergy. 1999 Oct;54(10):1105–1109. doi: 10.1034/j.1398-9995.1999.00239.x. [DOI] [PubMed] [Google Scholar]
  57. Docker A., Wattie J. M., Topping M. D., Luczynska C. M., Newman Taylor A. J., Pickering C. A., Thomas P., Gompertz D. Clinical and immunological investigations of respiratory disease in workers using reactive dyes. Br J Ind Med. 1987 Aug;44(8):534–541. doi: 10.1136/oem.44.8.534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  58. Douglas J. D., McSharry C., Blaikie L., Morrow T., Miles S., Franklin D. Occupational asthma caused by automated salmon processing. Lancet. 1995 Sep 16;346(8977):737–740. doi: 10.1016/s0140-6736(95)91505-2. [DOI] [PubMed] [Google Scholar]
  59. Drexler H., Schaller K. H., Nielsen J., Weber A., Weihrauch M., Welinder H., Skerfving S. Efficacy of measures of hygiene in workers sensitised to acid anhydrides and the influence of selection bias on the results. Occup Environ Med. 1999 Mar;56(3):202–205. doi: 10.1136/oem.56.3.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Droste Jos, Myny Katrien, Van Sprundel Marc, Kusters Eduard, Bulat Petar, Braeckman Lutgart, Vermeire Paul, Vanhoorne Michel. Allergic sensitization, symptoms, and lung function among bakery workers as compared with a nonexposed work population. J Occup Environ Med. 2003 Jun;45(6):648–655. doi: 10.1097/01.jom.0000071501.96740.f7. [DOI] [PubMed] [Google Scholar]
  61. El-Zein M., Malo J. L., Infante-Rivard C., Gautrin D. Incidence of probable occupational asthma and changes in airway calibre and responsiveness in apprentice welders. Eur Respir J. 2003 Sep;22(3):513–518. doi: 10.1183/09031936.03.00000903. [DOI] [PubMed] [Google Scholar]
  62. Fisher R., Saunders W. B., Murray S. J., Stave G. M. Prevention of laboratory animal allergy. J Occup Environ Med. 1998 Jul;40(7):609–613. doi: 10.1097/00043764-199807000-00005. [DOI] [PubMed] [Google Scholar]
  63. Flood D. F., Blofeld R. E., Bruce C. F., Hewitt J. I., Juniper C. P., Roberts D. M. Lung function, atopy, specific hypersensitivity, and smoking of workers in the enzyme detergent industry over 11 years. Br J Ind Med. 1985 Jan;42(1):43–50. doi: 10.1136/oem.42.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  64. Gannon P. F., Burge P. S. The SHIELD scheme in the West Midlands Region, United Kingdom. Midland Thoracic Society Research Group. Br J Ind Med. 1993 Sep;50(9):791–796. doi: 10.1136/oem.50.9.791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Gannon P. F., Newton D. T., Belcher J., Pantin C. F., Burge P. S. Development of OASYS-2: a system for the analysis of serial measurement of peak expiratory flow in workers with suspected occupational asthma. Thorax. 1996 May;51(5):484–489. doi: 10.1136/thx.51.5.484. [DOI] [PMC free article] [PubMed] [Google Scholar]
  66. Gannon P. F., Weir D. C., Robertson A. S., Burge P. S. Health, employment, and financial outcomes in workers with occupational asthma. Br J Ind Med. 1993 Jun;50(6):491–496. doi: 10.1136/oem.50.6.491. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Gautrin D., Ghezzo H., Infante-Rivard C., Malo J. L. Natural history of sensitization, symptoms and occupational diseases in apprentices exposed to laboratory animals. Eur Respir J. 2001 May;17(5):904–908. doi: 10.1183/09031936.01.17509040. [DOI] [PubMed] [Google Scholar]
  68. Gautrin D., Infante-Rivard C., Ghezzo H., Malo J. L. Incidence and host determinants of probable occupational asthma in apprentices exposed to laboratory animals. Am J Respir Crit Care Med. 2001 Mar;163(4):899–904. doi: 10.1164/ajrccm.163.4.2008011. [DOI] [PubMed] [Google Scholar]
  69. Glasziou Paul, Vandenbroucke Jan P., Chalmers Iain. Assessing the quality of research. BMJ. 2004 Jan 3;328(7430):39–41. doi: 10.1136/bmj.328.7430.39. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Gordon S. B., Curran A. D., Murphy J., Sillitoe C., Lee G., Wiley K., Morice A. H. Screening questionnaires for bakers' asthma--are they worth the effort? Occup Med (Lond) 1997 Aug;47(6):361–366. doi: 10.1093/occmed/47.6.361. [DOI] [PubMed] [Google Scholar]
  71. Grammer L. C., Shaughnessy M. A., Henderson J., Zeiss C. R., Kavich D. E., Collins M. J., Pecis K. M., Kenamore B. D. A clinical and immunologic study of workers with trimellitic-anhydride-induced immunologic lung disease after transfer to low exposure jobs. Am Rev Respir Dis. 1993 Jul;148(1):54–57. doi: 10.1164/ajrccm/148.1.54. [DOI] [PubMed] [Google Scholar]
  72. Grammer L. C., Shaughnessy M. A., Kenamore B. D. Clinical and immunologic outcome of 42 individuals with trimellitic anhydride-induced immunologic lung disease after transfer to low exposure. Allergy Asthma Proc. 2000 Nov-Dec;21(6):355–359. doi: 10.2500/108854100778249178. [DOI] [PubMed] [Google Scholar]
  73. Grammer L. C., Shaughnessy M. A., Lowenthal M., Yarnold P. R. Risk factors for immunologically mediated respiratory disease from hexahydrophthalic anhydride. J Occup Med. 1994 Jun;36(6):642–646. [PubMed] [Google Scholar]
  74. Grammer L. C., Shaughnessy M. A., Yarnold P. R. Risk factors for immunologically mediated disease in workers with respiratory symptoms when exposed to hexahydrophthalic anhydride. J Lab Clin Med. 1996 May;127(5):443–447. doi: 10.1016/s0022-2143(96)90061-x. [DOI] [PubMed] [Google Scholar]
  75. Grammer L., Shaughnessy M., Kenamore B. Utility of antibody in identifying individuals who have or will develop anhydride-induced respiratory disease. Chest. 1998 Oct;114(4):1199–1202. doi: 10.1378/chest.114.4.1199. [DOI] [PubMed] [Google Scholar]
  76. Grammer Leslie C., Ditto Anne M., Tripathi Anju, Harris Kathleen E. Prevalence and onset of rhinitis and conjunctivitis in subjects with occupational asthma caused by trimellitic anhydride (TMA). J Occup Environ Med. 2002 Dec;44(12):1179–1181. doi: 10.1097/00043764-200212000-00013. [DOI] [PubMed] [Google Scholar]
  77. Grammer Leslie C., Harris Kathleen E., Yarnold Paul R. Effect of respiratory protective devices on development of antibody and occupational asthma to an acid anhydride. Chest. 2002 Apr;121(4):1317–1322. doi: 10.1378/chest.121.4.1317. [DOI] [PubMed] [Google Scholar]
  78. Greenberg M., Milne J. F., Watt A. Survey of workers exposed to dusts containing derivatives of Bacillus subtilis. Br Med J. 1970 Jun 13;2(5710):629–633. doi: 10.1136/bmj.2.5710.629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  79. Hagmar L., Bellander T., Ranstam J., Skerfving S. Piperazine-induced airway symptoms: exposure-response relationships and selection in an occupational setting. Am J Ind Med. 1984;6(5):347–357. doi: 10.1002/ajim.4700060505. [DOI] [PubMed] [Google Scholar]
  80. Hargreave F. E., Ramsdale E. H., Pugsley S. O. Occupational asthma without bronchial hyperresponsiveness. Am Rev Respir Dis. 1984 Sep;130(3):513–515. doi: 10.1164/arrd.1984.130.3.513. [DOI] [PubMed] [Google Scholar]
  81. Heederik D., Houba R. An exploratory quantitative risk assessment for high molecular weight sensitizers: wheat flour. Ann Occup Hyg. 2001 Apr;45(3):175–185. [PubMed] [Google Scholar]
  82. Heederik D., Venables K. M., Malmberg P., Hollander A., Karlsson A. S., Renström A., Doekes G., Nieuwenhijsen M., Gordon S. Exposure-response relationships for work-related sensitization in workers exposed to rat urinary allergens: results from a pooled study. J Allergy Clin Immunol. 1999 Apr;103(4):678–684. doi: 10.1016/s0091-6749(99)70242-3. [DOI] [PubMed] [Google Scholar]
  83. Henneberger P. K., Stanbury M. J., Trimbath L. S., Kipen H. M. The use of portable peak flowmeters in the surveillance of occupational asthma. Chest. 1991 Dec;100(6):1515–1521. doi: 10.1378/chest.100.6.1515. [DOI] [PubMed] [Google Scholar]
  84. Hnizdo E., Esterhuizen T. M., Rees D., Lalloo U. G. Occupational asthma as identified by the Surveillance of Work-related and Occupational Respiratory Diseases programme in South Africa. Clin Exp Allergy. 2001 Jan;31(1):32–39. doi: 10.1046/j.1365-2222.2001.00981.x. [DOI] [PubMed] [Google Scholar]
  85. Hollander A., Heederik D., Brunekreef B. Work-related changes in peak expiratory flow among laboratory animal workers. Eur Respir J. 1998 Apr;11(4):929–936. doi: 10.1183/09031936.98.11040929. [DOI] [PubMed] [Google Scholar]
  86. Horne C., Quintana P. J., Keown P. A., Dimich-Ward H., Chan-Yeung M. Distribution of DRB1 and DQB1 HLA class II alleles in occupational asthma due to western red cedar. Eur Respir J. 2000 May;15(5):911–914. doi: 10.1034/j.1399-3003.2000.15e17.x. [DOI] [PubMed] [Google Scholar]
  87. Houba R., Heederik D. J., Doekes G., van Run P. E. Exposure-sensitization relationship for alpha-amylase allergens in the baking industry. Am J Respir Crit Care Med. 1996 Jul;154(1):130–136. doi: 10.1164/ajrccm.154.1.8680668. [DOI] [PubMed] [Google Scholar]
  88. Houba R., Heederik D., Doekes G. Wheat sensitization and work-related symptoms in the baking industry are preventable. An epidemiologic study. Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1499–1503. doi: 10.1164/ajrccm.158.5.9803055. [DOI] [PubMed] [Google Scholar]
  89. Howe W., Venables K. M., Topping M. D., Dally M. B., Hawkins R., Law J. S., Taylor A. J. Tetrachlorophthalic anhydride asthma: evidence for specific IgE antibody. J Allergy Clin Immunol. 1983 Jan;71(1 Pt 1):5–11. doi: 10.1016/0091-6749(83)90539-0. [DOI] [PubMed] [Google Scholar]
  90. Hudson P., Cartier A., Pineau L., Lafrance M., St-Aubin J. J., Dubois J. Y., Malo J. L. Follow-up of occupational asthma caused by crab and various agents. J Allergy Clin Immunol. 1985 Nov;76(5):682–688. doi: 10.1016/0091-6749(85)90671-2. [DOI] [PubMed] [Google Scholar]
  91. Jaakkola Jouni J. K., Piipari Ritva, Jaakkola Maritta S. Occupation and asthma: a population-based incident case-control study. Am J Epidemiol. 2003 Nov 15;158(10):981–987. doi: 10.1093/aje/kwg238. [DOI] [PubMed] [Google Scholar]
  92. Jeal Hayley, Draper Adrian, Jones Meinir, Harris Jessica, Welsh Ken, Taylor Anthony Newman, Cullinan Paul. HLA associations with occupational sensitization to rat lipocalin allergens: a model for other animal allergies? J Allergy Clin Immunol. 2003 Apr;111(4):795–799. doi: 10.1067/mai.2003.176. [DOI] [PubMed] [Google Scholar]
  93. Johnsen C. R., Sorensen T. B., Ingemann Larsen A., Bertelsen Secher A., Andreasen E., Kofoed G. S., Fredslund Nielsen L., Gyntelberg F. Allergy risk in an enzyme producing plant: a retrospective follow up study. Occup Environ Med. 1997 Sep;54(9):671–675. doi: 10.1136/oem.54.9.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  94. Johnson A. R., Dimich-Ward H. D., Manfreda J., Becklake M. R., Ernst P., Sears M. R., Bowie D. M., Sweet L., Chan-Yeung M. Occupational asthma in adults in six Canadian communities. Am J Respir Crit Care Med. 2000 Dec;162(6):2058–2062. doi: 10.1164/ajrccm.162.6.9805079. [DOI] [PubMed] [Google Scholar]
  95. Juniper C. P., How M. J., Goodwin B. F., Kinshott A. K. Bacillus subtilis enzymes: a 7-year clinical, epidemiological and immunological study of an industrial allergen. J Soc Occup Med. 1977 Jan;27(1):3–12. doi: 10.1093/occmed/27.1.3. [DOI] [PubMed] [Google Scholar]
  96. Karjalainen A., Kurppa K., Virtanen S., Keskinen H., Nordman H. Incidence of occupational asthma by occupation and industry in Finland. Am J Ind Med. 2000 May;37(5):451–458. doi: 10.1002/(sici)1097-0274(200005)37:5<451::aid-ajim1>3.0.co;2-u. [DOI] [PubMed] [Google Scholar]
  97. Karjalainen Antti, Kurppa Kari, Martikainen Rami, Karjalainen Jussi, Klaukka Timo. Exploration of asthma risk by occupation--extended analysis of an incidence study of the Finnish population. Scand J Work Environ Health. 2002 Feb;28(1):49–57. doi: 10.5271/sjweh.646. [DOI] [PubMed] [Google Scholar]
  98. Karjalainen Antti, Martikainen Rami, Klaukka Timo, Saarinen Kimmo, Uitti Jukka. Risk of asthma among Finnish patients with occupational rhinitis. Chest. 2003 Jan;123(1):283–288. doi: 10.1378/chest.123.1.283. [DOI] [PubMed] [Google Scholar]
  99. Kim Y. K., Son J. W., Kim H. Y., Park H. S., Lee M. H., Cho S. H., Min K. U., Kim Y. Y. New occupational allergen in citrus farmers: citrus red mite (Panonychus citri). Ann Allergy Asthma Immunol. 1999 Feb;82(2):223–228. doi: 10.1016/S1081-1206(10)62601-4. [DOI] [PubMed] [Google Scholar]
  100. Kogevinas M., Antó J. M., Soriano J. B., Tobias A., Burney P. The risk of asthma attributable to occupational exposures. A population-based study in Spain. Spanish Group of the European Asthma Study. Am J Respir Crit Care Med. 1996 Jul;154(1):137–143. doi: 10.1164/ajrccm.154.1.8680669. [DOI] [PubMed] [Google Scholar]
  101. Kogevinas M., Antó J. M., Sunyer J., Tobias A., Kromhout H., Burney P. Occupational asthma in Europe and other industrialised areas: a population-based study. European Community Respiratory Health Survey Study Group. Lancet. 1999 May 22;353(9166):1750–1754. doi: 10.1016/s0140-6736(98)07397-8. [DOI] [PubMed] [Google Scholar]
  102. Kor A. C., Lee H. S., Chee C. B., Wang Y. T. Occupational asthma in Singapore. Singapore Med J. 2001 Aug;42(8):373–377. [PubMed] [Google Scholar]
  103. Koskela Heikki, Taivainen Antti, Tukiainen Hannu, Chan Hak-Kim. Inhalation challenge with bovine dander allergens: who needs it? Chest. 2003 Jul;124(1):383–391. doi: 10.1378/chest.124.1.383. [DOI] [PubMed] [Google Scholar]
  104. Krakowiak A., Palczyñski C., Walusiak J., Wittczak T., Ruta U., Dudek W., Szulc B. Allergy to animal fur and feathers among zoo workers. Int Arch Occup Environ Health. 2002 Jul 5;75 (Suppl):S113–S116. doi: 10.1007/s00420-002-0346-0. [DOI] [PubMed] [Google Scholar]
  105. Krakowiak A., Szulc B., Górski P. Occupational respiratory diseases in laboratory animal workers: initial results. Int J Occup Med Environ Health. 1997;10(1):31–36. [PubMed] [Google Scholar]
  106. Kraw M., Tarlo S. M. Isocyanate medical surveillance: respiratory referrals from a foam manufacturing plant over a five-year period. Am J Ind Med. 1999 Jan;35(1):87–91. doi: 10.1002/(sici)1097-0274(199901)35:1<87::aid-ajim12>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  107. Kruize H., Post W., Heederik D., Martens B., Hollander A., van der Beek E. Respiratory allergy in laboratory animal workers: a retrospective cohort study using pre-employment screening data. Occup Environ Med. 1997 Nov;54(11):830–835. doi: 10.1136/oem.54.11.830. [DOI] [PMC free article] [PubMed] [Google Scholar]
  108. Laoprasert N., Swanson M. C., Jones R. T., Schroeder D. R., Yunginger J. W. Inhalation challenge testing of latex-sensitive health care workers and the effectiveness of laminar flow HEPA-filtered helmets in reducing rhinoconjunctival and asthmatic reactions. J Allergy Clin Immunol. 1998 Dec;102(6 Pt 1):998–1004. doi: 10.1016/s0091-6749(98)70338-0. [DOI] [PubMed] [Google Scholar]
  109. Larbanois A., Jamart J., Delwiche J. P., Vandenplas O. Socioeconomic outcome of subjects experiencing asthma symptoms at work. Eur Respir J. 2002 Jun;19(6):1107–1113. doi: 10.1183/09031936.02.00272202a. [DOI] [PubMed] [Google Scholar]
  110. Lemière C., Cartier A., Dolovich J., Chan-Yeung M., Grammer L., Ghezzo H., L'Archevêque J., Malo J. L. Outcome of specific bronchial responsiveness to occupational agents after removal from exposure. Am J Respir Crit Care Med. 1996 Aug;154(2 Pt 1):329–333. doi: 10.1164/ajrccm.154.2.8756802. [DOI] [PubMed] [Google Scholar]
  111. Lemière C., Cartier A., Malo J. L., Lehrer S. B. Persistent specific bronchial reactivity to occupational agents in workers with normal nonspecific bronchial reactivity. Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):976–980. doi: 10.1164/ajrccm.162.3.9910031. [DOI] [PubMed] [Google Scholar]
  112. Leroyer C., Perfetti L., Trudeau C., L'Archeveque J., Chan-Yeung M., Malo J. L. Comparison of serial monitoring of peak expiratory flow and FEV1 in the diagnosis of occupational asthma. Am J Respir Crit Care Med. 1998 Sep;158(3):827–832. doi: 10.1164/ajrccm.158.3.9707093. [DOI] [PubMed] [Google Scholar]
  113. Levy D., Allouache S., Chabane M. H., Leynadier F., Burney P. Powder-free protein-poor natural rubber latex gloves and latex sensitization. JAMA. 1999 Mar 17;281(11):988–988. doi: 10.1001/jama.281.11.988. [DOI] [PubMed] [Google Scholar]
  114. Lin F. J., Chen H., Chan-Yeung M. New method for an occupational dust challenge test. Occup Environ Med. 1995 Jan;52(1):54–56. doi: 10.1136/oem.52.1.54. [DOI] [PMC free article] [PubMed] [Google Scholar]
  115. Liss G. M., Bernstein D., Genesove L., Roos J. O., Lim J. Assessment of risk factors for IgE-mediated sensitization to tetrachlorophthalic anhydride. J Allergy Clin Immunol. 1993 Aug;92(2):237–247. doi: 10.1016/0091-6749(93)90167-e. [DOI] [PubMed] [Google Scholar]
  116. Liss G. M., Tarlo S. M. Peak expiratory flow rates in possible occupational asthma. Chest. 1991 Jul;100(1):63–69. doi: 10.1378/chest.100.1.63. [DOI] [PubMed] [Google Scholar]
  117. Lozewicz S., Assoufi B. K., Hawkins R., Taylor A. J. Outcome of asthma induced by isocyanates. Br J Dis Chest. 1987 Jan;81(1):14–22. doi: 10.1016/0007-0971(87)90103-3. [DOI] [PubMed] [Google Scholar]
  118. Maghni Karim, Lemière Catherine, Ghezzo Heberto, Yuquan Wu, Malo Jean-Luc. Airway inflammation after cessation of exposure to agents causing occupational asthma. Am J Respir Crit Care Med. 2003 Oct 24;169(3):367–372. doi: 10.1164/rccm.200309-1238OC. [DOI] [PubMed] [Google Scholar]
  119. Malo J. L., Cartier A., Ghezzo H., Chan-Yeung M. Compliance with peak expiratory flow readings affects the within- and between-reader reproducibility of interpretation of graphs in subjects investigated for occupational asthma. J Allergy Clin Immunol. 1996 Dec;98(6 Pt 1):1132–1134. doi: 10.1016/s0091-6749(96)80207-7. [DOI] [PubMed] [Google Scholar]
  120. Malo J. L., Côté J., Cartier A., Boulet L. P., L'Archevêque J., Chan-Yeung M. How many times per day should peak expiratory flow rates be assessed when investigating occupational asthma? Thorax. 1993 Dec;48(12):1211–1217. doi: 10.1136/thx.48.12.1211. [DOI] [PMC free article] [PubMed] [Google Scholar]
  121. Malo J. L., Dewitte J. D., Cartier A., Ghezzo H., L'Archevêque J., Boulet L. P., Côté J., Bédard G., Boucher S., Champagne F. Le système québécois d'indemnisation pour asthme professionnel. Description, efficacité et coûts. Rev Mal Respir. 1993;10(4):313–323. [PubMed] [Google Scholar]
  122. Malo J. L., Ghezzo H., L'Archevêque J., Lagier F., Perrin B., Cartier A. Is the clinical history a satisfactory means of diagnosing occupational asthma? Am Rev Respir Dis. 1991 Mar;143(3):528–532. doi: 10.1164/ajrccm/143.3.528. [DOI] [PubMed] [Google Scholar]
  123. Malo J. L., Lemière C., Desjardins A., Cartier A. Prevalence and intensity of rhinoconjunctivitis in subjects with occupational asthma. Eur Respir J. 1997 Jul;10(7):1513–1515. doi: 10.1183/09031936.97.10071513. [DOI] [PubMed] [Google Scholar]
  124. Malo J. L., Trudeau C., Ghezzo H., L'Archevêque J., Cartier A. Do subjects investigated for occupational asthma through serial peak expiratory flow measurements falsify their results? J Allergy Clin Immunol. 1995 Nov;96(5 Pt 1):601–607. doi: 10.1016/s0091-6749(95)70258-x. [DOI] [PubMed] [Google Scholar]
  125. Mapp C. E., Beghè B., Balboni A., Zamorani G., Padoan M., Jovine L., Baricordi O. R., Fabbri L. M. Association between HLA genes and susceptibility to toluene diisocyanate-induced asthma. Clin Exp Allergy. 2000 May;30(5):651–656. doi: 10.1046/j.1365-2222.2000.00807.x. [DOI] [PubMed] [Google Scholar]
  126. Mapp C. E., Corona P. C., De Marzo N., Fabbri L. Persistent asthma due to isocyanates. A follow-up study of subjects with occupational asthma due to toluene diisocyanate (TDI). Am Rev Respir Dis. 1988 Jun;137(6):1326–1329. doi: 10.1164/ajrccm/137.6.1326. [DOI] [PubMed] [Google Scholar]
  127. Mapp Cristina E., Fryer Anthony A., De Marzo Nicoletta, Pozzato Valeria, Padoan Michele, Boschetto Piera, Strange Richard C., Hemmingsen Anja, Spiteri Monica A. Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates. J Allergy Clin Immunol. 2002 May;109(5):867–872. doi: 10.1067/mai.2002.123234. [DOI] [PubMed] [Google Scholar]
  128. Marabini A., Brugnami G., Curradi F., Severini C., Siracusa A. Risposta al test di provocazione bronchiale specifica ed evoluzione dell'asma professionale. Studio longitudinale in soggetti con asma da toluendiisocianato (TDI). Med Lav. 1994 Mar-Apr;85(2):134–141. [PubMed] [Google Scholar]
  129. Marabini A., Dimich-Ward H., Kwan S. Y., Kennedy S. M., Waxler-Morrison N., Chan-Yeung M. Clinical and socioeconomic features of subjects with red cedar asthma. A follow-up study. Chest. 1993 Sep;104(3):821–824. doi: 10.1378/chest.104.3.821. [DOI] [PubMed] [Google Scholar]
  130. McDonald J. C., Keynes H. L., Meredith S. K. Reported incidence of occupational asthma in the United Kingdom, 1989-97. Occup Environ Med. 2000 Dec;57(12):823–829. doi: 10.1136/oem.57.12.823. [DOI] [PMC free article] [PubMed] [Google Scholar]
  131. McSharry C., Anderson K., McKay I. C., Colloff M. J., Feyerabend C., Wilson R. B., Wilkinson P. C. The IgE and IgG antibody responses to aerosols of Nephrops norvegicus (prawn) antigens: the association with clinical hypersensitivity and with cigarette smoking. Clin Exp Immunol. 1994 Sep;97(3):499–504. doi: 10.1111/j.1365-2249.1994.tb06116.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  132. Meijer E., Grobbee D. E., Heederik D. Detection of workers sensitised to high molecular weight allergens: a diagnostic study in laboratory animal workers. Occup Environ Med. 2002 Mar;59(3):189–195. doi: 10.1136/oem.59.3.189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  133. Meredith S. K., Bugler J., Clark R. L. Isocyanate exposure and occupational asthma: a case-referent study. Occup Environ Med. 2000 Dec;57(12):830–836. doi: 10.1136/oem.57.12.830. [DOI] [PMC free article] [PubMed] [Google Scholar]
  134. Meredith S. K., Taylor V. M., McDonald J. C. Occupational respiratory disease in the United Kingdom 1989: a report to the British Thoracic Society and the Society of Occupational Medicine by the SWORD project group. Br J Ind Med. 1991 May;48(5):292–298. doi: 10.1136/oem.48.5.292. [DOI] [PMC free article] [PubMed] [Google Scholar]
  135. Merget R., Dierkes A., Rueckmann A., Bergmann E. M., Schultze-Werninghaus G. Absence of relationship between degree of nonspecific and specific bronchial responsiveness in occupational asthma due to platinum salts. Eur Respir J. 1996 Feb;9(2):211–216. doi: 10.1183/09031936.96.09020211. [DOI] [PubMed] [Google Scholar]
  136. Merget R., Kulzer R., Dierkes-Globisch A., Breitstadt R., Gebler A., Kniffka A., Artelt S., Koenig H. P., Alt F., Vormberg R. Exposure-effect relationship of platinum salt allergy in a catalyst production plant: conclusions from a 5-year prospective cohort study. J Allergy Clin Immunol. 2000 Feb;105(2 Pt 1):364–370. doi: 10.1016/s0091-6749(00)90089-7. [DOI] [PubMed] [Google Scholar]
  137. Merget R., Reineke M., Rueckmann A., Bergmann E. M., Schultze-Werninghaus G. Nonspecific and specific bronchial responsiveness in occupational asthma caused by platinum salts after allergen avoidance. Am J Respir Crit Care Med. 1994 Oct;150(4):1146–1149. doi: 10.1164/ajrccm.150.4.7921450. [DOI] [PubMed] [Google Scholar]
  138. Merget R., Schulte A., Gebler A., Breitstadt R., Kulzer R., Berndt E. D., Baur X., Schultze-Werninghaus G. Outcome of occupational asthma due to platinum salts after transferral to low-exposure areas. Int Arch Occup Environ Health. 1999 Jan;72(1):33–39. doi: 10.1007/s004200050331. [DOI] [PubMed] [Google Scholar]
  139. Merget R., Schultze-Werninghaus G., Bode F., Bergmann E. M., Zachgo W., Meier-Sydow J. Quantitative skin prick and bronchial provocation tests with platinum salt. Br J Ind Med. 1991 Dec;48(12):830–837. doi: 10.1136/oem.48.12.830. [DOI] [PMC free article] [PubMed] [Google Scholar]
  140. Merget R., Schultze-Werninghaus G., Muthorst T., Friedrich W., Meier-Sydow J. Asthma due to the complex salts of platinum--a cross-sectional survey of workers in a platinum refinery. Clin Allergy. 1988 Nov;18(6):569–580. doi: 10.1111/j.1365-2222.1988.tb02908.x. [DOI] [PubMed] [Google Scholar]
  141. Meyer J. D., Holt D. L., Chen Y., Cherry N. M., McDonald J. C. SWORD '99: surveillance of work-related and occupational respiratory disease in the UK. Occup Med (Lond) 2001 May;51(3):204–208. doi: 10.1093/occmed/51.3.204. [DOI] [PubMed] [Google Scholar]
  142. Meyer J. D., Holt D. L., Cherry N. M., McDonald J. C. SWORD '98: surveillance of work-related and occupational respiratory disease in the UK. Occup Med (Lond) 1999 Nov;49(8):485–489. doi: 10.1093/occmed/49.8.485. [DOI] [PubMed] [Google Scholar]
  143. Michie Susan, Johnston Marie. Changing clinical behaviour by making guidelines specific. BMJ. 2004 Feb 7;328(7435):343–345. doi: 10.1136/bmj.328.7435.343. [DOI] [PMC free article] [PubMed] [Google Scholar]
  144. Milton D. K., Solomon G. M., Rosiello R. A., Herrick R. F. Risk and incidence of asthma attributable to occupational exposure among HMO members. Am J Ind Med. 1998 Jan;33(1):1–10. doi: 10.1002/(sici)1097-0274(199801)33:1<1::aid-ajim1>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  145. Moller D. R., Brooks S. M., McKay R. T., Cassedy K., Kopp S., Bernstein I. L. Chronic asthma due to toluene diisocyanate. Chest. 1986 Oct;90(4):494–499. doi: 10.1378/chest.90.4.494. [DOI] [PubMed] [Google Scholar]
  146. Moscato G., Dellabianca A., Perfetti L., Bramè B., Galdi E., Niniano R., Paggiaro P. Occupational asthma: a longitudinal study on the clinical and socioeconomic outcome after diagnosis. Chest. 1999 Jan;115(1):249–256. doi: 10.1378/chest.115.1.249. [DOI] [PubMed] [Google Scholar]
  147. Moscato G., Dellabianca A., Vinci G., Candura S. M., Bossi M. C. Toluene diisocyanate-induced asthma: clinical findings and bronchial responsiveness studies in 113 exposed subjects with work-related respiratory symptoms. J Occup Med. 1991 Jun;33(6):720–725. doi: 10.1097/00043764-199106000-00014. [DOI] [PubMed] [Google Scholar]
  148. Musk A. W., Venables K. M., Crook B., Nunn A. J., Hawkins R., Crook G. D., Graneek B. J., Tee R. D., Farrer N., Johnson D. A. Respiratory symptoms, lung function, and sensitisation to flour in a British bakery. Br J Ind Med. 1989 Sep;46(9):636–642. doi: 10.1136/oem.46.9.636. [DOI] [PMC free article] [PubMed] [Google Scholar]
  149. Müller-Wening D., Neuhauss M. Protective effect of respiratory devices in farmers with occupational asthma. Eur Respir J. 1998 Sep;12(3):569–572. doi: 10.1183/09031936.98.12030569. [DOI] [PubMed] [Google Scholar]
  150. Newhouse M. L., Tagg B., Pocock S. J., McEwan A. C. An epidemiological study of workers producing enzyme washing powders. Lancet. 1970 Apr 4;1(7649):689–693. doi: 10.1016/s0140-6736(70)90924-4. [DOI] [PubMed] [Google Scholar]
  151. Newill C. A., Evans R., 3rd, Khoury M. J. Preemployment screening for allergy to laboratory animals: epidemiologic evaluation of its potential usefulness. J Occup Med. 1986 Nov;28(11):1158–1164. [PubMed] [Google Scholar]
  152. Newman Taylor A. J., Cullinan P., Lympany P. A., Harris J. M., Dowdeswell R. J., du Bois R. M. Interaction of HLA phenotype and exposure intensity in sensitization to complex platinum salts. Am J Respir Crit Care Med. 1999 Aug;160(2):435–438. doi: 10.1164/ajrccm.160.2.9807065. [DOI] [PubMed] [Google Scholar]
  153. Nielsen J., Welinder H., Jönsson B., Axmon A., Rylander L., Skerfving S. Exposure to hexahydrophthalic and methylhexahydrophthalic anhydrides--dose-response for sensitization and airway effects. Scand J Work Environ Health. 2001 Oct;27(5):327–334. doi: 10.5271/sjweh.621. [DOI] [PubMed] [Google Scholar]
  154. Nieuwenhuijsen M. J., Heederik D., Doekes G., Venables K. M., Newman Taylor A. J. Exposure-response relations of alpha-amylase sensitisation in British bakeries and flour mills. Occup Environ Med. 1999 Mar;56(3):197–201. doi: 10.1136/oem.56.3.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  155. Niezborala M., Garnier R. Allergy to complex platinum salts: A historical prospective cohort study. Occup Environ Med. 1996 Apr;53(4):252–257. doi: 10.1136/oem.53.4.252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  156. Obase Y., Shimoda T., Mitsuta K., Matsuse H., Kohno S. Two patients with occupational asthma who returned to work with dust respirators. Occup Environ Med. 2000 Jan;57(1):62–64. doi: 10.1136/oem.57.1.62. [DOI] [PMC free article] [PubMed] [Google Scholar]
  157. Ortega H. G., Daroowalla F., Petsonk E. L., Lewis D., Berardinelli S., Jr, Jones W., Kreiss K., Weissman D. N. Respiratory symptoms among crab processing workers in Alaska: epidemiological and environmental assessment. Am J Ind Med. 2001 Jun;39(6):598–607. doi: 10.1002/ajim.1059. [DOI] [PubMed] [Google Scholar]
  158. Osterman K., Zetterström O., Johansson S. G. Coffee worker's allergy. Allergy. 1982 Jul;37(5):313–322. doi: 10.1111/j.1398-9995.1982.tb01917.x. [DOI] [PubMed] [Google Scholar]
  159. Padoan M., Pozzato V., Simoni M., Zedda L., Milan G., Bononi I., Piola C., Maestrelli P., Boschetto P., Mapp C. E. Long-term follow-up of toluene diisocyanate-induced asthma. Eur Respir J. 2003 Apr;21(4):637–640. doi: 10.1183/09031936.03.00060703. [DOI] [PubMed] [Google Scholar]
  160. Paggiaro P. L., Loi A. M., Rossi O., Ferrante B., Pardi F., Roselli M. G., Baschieri L. Follow-up study of patients with respiratory disease due to toluene diisocyanate (TDI). Clin Allergy. 1984 Sep;14(5):463–469. doi: 10.1111/j.1365-2222.1984.tb02230.x. [DOI] [PubMed] [Google Scholar]
  161. Paggiaro P. L., Vagaggini B., Dente F. L., Bacci E., Bancalari L., Carrara M., Di Franco A., Giannini D., Giuntini C. Bronchial hyperresponsiveness and toluene diisocyanate. Long-term change in sensitized asthmatic subjects. Chest. 1993 Apr;103(4):1123–1128. doi: 10.1378/chest.103.4.1123. [DOI] [PubMed] [Google Scholar]
  162. Park H. S., Kim Y. J., Lee M. K., Hong C. S. Occupational asthma and IgE antibodies to reactive dyes. Yonsei Med J. 1989 Sep;30(3):298–304. doi: 10.3349/ymj.1989.30.3.298. [DOI] [PubMed] [Google Scholar]
  163. Park H. S., Nahm D. H. Prognostic factors for toluene diisocyanate-induced occupational asthma after removal from exposure. Clin Exp Allergy. 1997 Oct;27(10):1145–1150. [PubMed] [Google Scholar]
  164. Park J. W., Kim C. W., Kim K. S., Choi S. Y., Kang D. B., Ko S. H., Won J. U., Yang J. Y., Hong C. S. Role of skin prick test and serological measurement of specific IgE in the diagnosis of occupational asthma resulting from exposure to vinyl sulphone reactive dyes. Occup Environ Med. 2001 Jun;58(6):411–416. doi: 10.1136/oem.58.6.411. [DOI] [PMC free article] [PubMed] [Google Scholar]
  165. Perrin B., Lagier F., L'Archevêque J., Cartier A., Boulet L. P., Côté J., Malo J. L. Occupational asthma: validity of monitoring of peak expiratory flow rates and non-allergic bronchial responsiveness as compared to specific inhalation challenge. Eur Respir J. 1992 Jan;5(1):40–48. [PubMed] [Google Scholar]
  166. Pezzini A., Riviera A., Paggiaro P., Spiazzi A., Gerosa F., Filieri M., Toma G., Tridente G. Specific IgE antibodies in twenty-eight workers with diisocyanate-induced bronchial asthma. Clin Allergy. 1984 Sep;14(5):453–461. doi: 10.1111/j.1365-2222.1984.tb02229.x. [DOI] [PubMed] [Google Scholar]
  167. Piirilä P. L., Nordman H., Keskinen H. M., Luukkonen R., Salo S. P., Tuomi T. O., Tuppurainen M. Long-term follow-up of hexamethylene diisocyanate-, diphenylmethane diisocyanate-, and toluene diisocyanate-induced asthma. Am J Respir Crit Care Med. 2000 Aug;162(2 Pt 1):516–522. doi: 10.1164/ajrccm.162.2.9909026. [DOI] [PubMed] [Google Scholar]
  168. Piirilä P., Wikman H., Luukkonen R., Käriä K., Rosenberg C., Nordman H., Norppa H., Vainio H., Hirvonen A. Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure. Pharmacogenetics. 2001 Jul;11(5):437–445. doi: 10.1097/00008571-200107000-00007. [DOI] [PubMed] [Google Scholar]
  169. Pisati G., Baruffini A., Zedda S. Toluene diisocyanate induced asthma: outcome according to persistence or cessation of exposure. Br J Ind Med. 1993 Jan;50(1):60–64. doi: 10.1136/oem.50.1.60. [DOI] [PMC free article] [PubMed] [Google Scholar]
  170. Platts-Mills T. A., Longbottom J., Edwards J., Cockroft A., Wilkins S. Occupational asthma and rhinitis related to laboratory rats: serum IgG and IgE antibodies to the rat urinary allergen. J Allergy Clin Immunol. 1987 Mar;79(3):505–515. doi: 10.1016/0091-6749(87)90369-1. [DOI] [PubMed] [Google Scholar]
  171. Prichard M. G., Ryan G., Musk A. W. Wheat flour sensitisation and airways disease in urban bakers. Br J Ind Med. 1984 Nov;41(4):450–454. doi: 10.1136/oem.41.4.450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  172. Provencher S., Labrèche F. P., De Guire L. Physician based surveillance system for occupational respiratory diseases: the experience of PROPULSE, Québec, Canada. Occup Environ Med. 1997 Apr;54(4):272–276. doi: 10.1136/oem.54.4.272. [DOI] [PMC free article] [PubMed] [Google Scholar]
  173. Quirce S., Contreras G., Dybuncio A., Chan-Yeung M. Peak expiratory flow monitoring is not a reliable method for establishing the diagnosis of occupational asthma. Am J Respir Crit Care Med. 1995 Sep;152(3):1100–1102. doi: 10.1164/ajrccm.152.3.7663790. [DOI] [PubMed] [Google Scholar]
  174. Redlich C. A., Stowe M. H., Wisnewski A. V., Eisen E. A., Karol M. H., Lemus R., Holm C. T., Chung J. S., Sparer J., Liu Y. Subclinical immunologic and physiologic responses in hexamethylene diisocyanate-exposed auto body shop workers. Am J Ind Med. 2001 Jun;39(6):587–597. doi: 10.1002/ajim.1058. [DOI] [PubMed] [Google Scholar]
  175. Reijula K., Haahtela T., Klaukka T., Rantanen J. Incidence of occupational asthma and persistent asthma in young adults has increased in Finland. Chest. 1996 Jul;110(1):58–61. doi: 10.1378/chest.110.1.58. [DOI] [PubMed] [Google Scholar]
  176. Renström A., Malmberg P., Larsson K., Sundblad B. M., Larsson P. H. Prospective study of laboratory-animal allergy: factors predisposing to sensitization and development of allergic symptoms. Allergy. 1994 Aug;49(7):548–552. doi: 10.1111/j.1398-9995.1994.tb01127.x. [DOI] [PubMed] [Google Scholar]
  177. Revsbech P., Andersen G. Diurnal variation in peak expiratory flow rate among grain elevator workers. Br J Ind Med. 1989 Aug;46(8):566–569. doi: 10.1136/oem.46.8.566. [DOI] [PMC free article] [PubMed] [Google Scholar]
  178. Ricciardi Luisa, Fedele Roberta, Saitta Salvatore, Tigano Valeria, Mazzeo Letteria, Fogliani Olga, Barber Domingo, Isola Stefania. Occupational asthma due to exposure to iroko wood dust. Ann Allergy Asthma Immunol. 2003 Oct;91(4):393–397. doi: 10.1016/S1081-1206(10)61687-0. [DOI] [PubMed] [Google Scholar]
  179. Rihs H. P., Barbalho-Krölls T., Huber H., Baur X. No evidence for the influence of HLA class II in alleles in isocyanate-induced asthma. Am J Ind Med. 1997 Nov;32(5):522–527. doi: 10.1002/(sici)1097-0274(199711)32:5<522::aid-ajim13>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  180. Romano C., Sulotto F., Piolatto G., Ciacco C., Capellaro E., Falagiani P., Constable D. W., Verga A., Scansetti G. Factors related to the development of sensitization to green coffee and castor bean allergens among coffee workers. Clin Exp Allergy. 1995 Jul;25(7):643–650. doi: 10.1111/j.1365-2222.1995.tb01112.x. [DOI] [PubMed] [Google Scholar]
  181. Rosenberg N., Garnier R., Rousselin X., Mertz R., Gervais P. Clinical and socio-professional fate of isocyanate-induced asthma. Clin Allergy. 1987 Jan;17(1):55–61. doi: 10.1111/j.1365-2222.1987.tb02319.x. [DOI] [PubMed] [Google Scholar]
  182. Ross D. J., McDonald J. C. Health and employment after a diagnosis of occupational asthma: a descriptive study. Occup Med (Lond) 1998 May;48(4):219–225. doi: 10.1093/occmed/48.4.219. [DOI] [PubMed] [Google Scholar]
  183. Sallie B. A., Ross D. J., Meredith S. K., McDonald J. C. SWORD '93. Surveillance of work-related and occupational respiratory disease in the UK. Occup Med (Lond) 1994 Sep;44(4):177–182. doi: 10.1093/occmed/44.4.177. [DOI] [PubMed] [Google Scholar]
  184. Schlünssen V., Schaumburg I., Heederik D., Taudorf E., Sigsgaard T. Indices of asthma among atopic and non-atopic woodworkers. Occup Environ Med. 2004 Jun;61(6):504–511. doi: 10.1136/oem.2003.007815. [DOI] [PMC free article] [PubMed] [Google Scholar]
  185. Sjöstedt L., Willers S., Orbaek P. A follow-up study of laboratory animal exposed workers: the influence of atopy for the development of occupational asthma. Am J Ind Med. 1993 Oct;24(4):459–469. doi: 10.1002/ajim.4700240410. [DOI] [PubMed] [Google Scholar]
  186. Sjöstedt L., Willers S., Orbaek P. Human leukocyte antigens in occupational allergy: a possible protective effect of HLA-B16 in laboratory animal allergy. Am J Ind Med. 1996 Oct;30(4):415–420. doi: 10.1002/(SICI)1097-0274(199610)30:4<415::AID-AJIM6>3.0.CO;2-U. [DOI] [PubMed] [Google Scholar]
  187. Sjöstedt L., Willers S. Predisposing factors in laboratory animal allergy: a study of atopy and environmental factors. Am J Ind Med. 1989;16(2):199–208. doi: 10.1002/ajim.4700160211. [DOI] [PubMed] [Google Scholar]
  188. Slovak A. J. Occupational asthma caused by a plastics blowing agent, azodicarbonamide. Thorax. 1981 Dec;36(12):906–909. doi: 10.1136/thx.36.12.906. [DOI] [PMC free article] [PubMed] [Google Scholar]
  189. Slovak A. J., Orr R. G., Teasdale E. L. Efficacy of the helmet respirator in occupational asthma due to laboratory animal allergy (LAA). Am Ind Hyg Assoc J. 1985 Aug;46(8):411–415. doi: 10.1080/15298668591395085. [DOI] [PubMed] [Google Scholar]
  190. Stenton S. C., Beach J. R., Avery A. J., Hendrick D. J. The value of questionnaires and spirometry in asthma surveillance programmes in the workplace. Occup Med (Lond) 1993 Nov;43(4):203–206. doi: 10.1093/occmed/43.4.203. [DOI] [PubMed] [Google Scholar]
  191. Taivainen A. I., Tukiainen H. O., Terho E. O., Husman K. R. Powered dust respirator helmets in the prevention of occupational asthma among farmers. Scand J Work Environ Health. 1998 Dec;24(6):503–507. doi: 10.5271/sjweh.375. [DOI] [PubMed] [Google Scholar]
  192. Talini D., Benvenuti A., Carrara M., Vaghetti E., Martin L. Bianchi, Paggiaro P. L. Diagnosis of flour-induced occupational asthma in a cross-sectional study. Respir Med. 2002 Apr;96(4):236–243. doi: 10.1053/rmed.2001.1259. [DOI] [PubMed] [Google Scholar]
  193. Tarlo S. M., Banks D., Liss G., Broder I. Outcome determinants for isocyanate induced occupational asthma among compensation claimants. Occup Environ Med. 1997 Oct;54(10):756–761. doi: 10.1136/oem.54.10.756. [DOI] [PMC free article] [PubMed] [Google Scholar]
  194. Tarlo S. M., Broder I. Outcome of assessments for occupational asthma. Chest. 1991 Aug;100(2):329–335. doi: 10.1378/chest.100.2.329. [DOI] [PubMed] [Google Scholar]
  195. Tarlo S. M., Easty A., Eubanks K., Parsons C. R., Min F., Juvet S., Liss G. M. Outcomes of a natural rubber latex control program in an Ontario teaching hospital. J Allergy Clin Immunol. 2001 Oct;108(4):628–633. doi: 10.1067/mai.2001.118792. [DOI] [PubMed] [Google Scholar]
  196. Tarlo S. M., Liss G. M., Dias C., Banks D. E. Assessment of the relationship between isocyanate exposure levels and occupational asthma. Am J Ind Med. 1997 Nov;32(5):517–521. doi: 10.1002/(sici)1097-0274(199711)32:5<517::aid-ajim12>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
  197. Tarlo S. M., Liss G. M., Yeung K. S. Changes in rates and severity of compensation claims for asthma due to diisocyanates: a possible effect of medical surveillance measures. Occup Environ Med. 2002 Jan;59(1):58–62. doi: 10.1136/oem.59.1.58. [DOI] [PMC free article] [PubMed] [Google Scholar]
  198. Tarlo S. M., Liss G., Corey P., Broder I. A workers' compensation claim population for occupational asthma. Comparison of subgroups. Chest. 1995 Mar;107(3):634–641. doi: 10.1378/chest.107.3.634. [DOI] [PubMed] [Google Scholar]
  199. Tee R. D., Cullinan P., Welch J., Burge P. S., Newman-Taylor A. J. Specific IgE to isocyanates: a useful diagnostic role in occupational asthma. J Allergy Clin Immunol. 1998 May;101(5):709–715. doi: 10.1016/S0091-6749(98)70181-2. [DOI] [PubMed] [Google Scholar]
  200. Torén K., Järvholm B., Brisman J., Hagberg S., Hermansson B. A., Lillienberg L. Adult-onset asthma and occupational exposures. Scand J Work Environ Health. 1999 Oct;25(5):430–435. doi: 10.5271/sjweh.456. [DOI] [PubMed] [Google Scholar]
  201. Ucgun I., Ozdemir N., Metintaş M., Metintaş S., Erginel S., Kolsuz M. Prevalence of occupational asthma among automobile and furniture painters in the center of Eskisehir (Turkey): the effects of atopy and smoking habits on occupational asthma. Allergy. 1998 Nov;53(11):1096–1100. doi: 10.1111/j.1398-9995.1998.tb03822.x. [DOI] [PubMed] [Google Scholar]
  202. Valentino M., Pizzichini M. A., Monaco F., Governa M. Latex-induced asthma in four healthcare workers in a regional hospital. Occup Med (Lond) 1994 Jul;44(3):161–164. doi: 10.1093/occmed/44.3.161. [DOI] [PubMed] [Google Scholar]
  203. Valentino M., Rapisarda V. Evoluzione dell'asma da isocianati in rapporto alla cessazione dell'esposizione: studio longitudinale su 50 soggetti. G Ital Med Lav Ergon. 2002 Jan-Mar;24(1):26–31. [PubMed] [Google Scholar]
  204. Vandenplas O., Binard-Van Cangh F., Brumagne A., Caroyer J. M., Thimpont J., Sohy C., Larbanois A., Jamart J. Occupational asthma in symptomatic workers exposed to natural rubber latex: evaluation of diagnostic procedures. J Allergy Clin Immunol. 2001 Mar;107(3):542–547. doi: 10.1067/mai.2001.113519. [DOI] [PubMed] [Google Scholar]
  205. Vandenplas O., Delwiche J. P., Depelchin S., Sibille Y., Vande Weyer R., Delaunois L. Latex gloves with a lower protein content reduce bronchial reactions in subjects with occupational asthma caused by latex. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):887–891. doi: 10.1164/ajrccm/151.3_Pt_1.887. [DOI] [PubMed] [Google Scholar]
  206. Vandenplas O., Delwiche J. P., Evrard G., Aimont P., van der Brempt X., Jamart J., Delaunois L. Prevalence of occupational asthma due to latex among hospital personnel. Am J Respir Crit Care Med. 1995 Jan;151(1):54–60. doi: 10.1164/ajrccm.151.1.7812572. [DOI] [PubMed] [Google Scholar]
  207. Vandenplas O., Delwiche J. P., Evrard G., Aimont P., van der Brempt X., Jamart J., Delaunois L. Prevalence of occupational asthma due to latex among hospital personnel. Am J Respir Crit Care Med. 1995 Jan;151(1):54–60. doi: 10.1164/ajrccm.151.1.7812572. [DOI] [PubMed] [Google Scholar]
  208. Vandenplas Olivier, Jamart Jacques, Delwiche Jean-Pierre, Evrard Geneviève, Larbanois Alexandra. Occupational asthma caused by natural rubber latex: outcome according to cessation or reduction of exposure. J Allergy Clin Immunol. 2002 Jan;109(1):125–130. doi: 10.1067/mai.2002.120760. [DOI] [PubMed] [Google Scholar]
  209. Vanhanen M., Tuomi T., Nordman H., Tupasela O., Holmberg P. C., Miettinen M., Mutanen P., Leisola M. Sensitization to industrial enzymes in enzyme research and production. Scand J Work Environ Health. 1997 Oct;23(5):385–391. doi: 10.5271/sjweh.236. [DOI] [PubMed] [Google Scholar]
  210. Vedal S., Chan-Yeung M., Enarson D. A., Chan H., Dorken E., Tse K. S. Plicatic acid-specific IgE and nonspecific bronchial hyperresponsiveness in western red-cedar workers. J Allergy Clin Immunol. 1986 Dec;78(6):1103–1109. doi: 10.1016/0091-6749(86)90257-5. [DOI] [PubMed] [Google Scholar]
  211. Venables K. M., Dally M. B., Burge P. S., Pickering C. A., Newman Taylor A. J. Occupational asthma in a steel coating plant. Br J Ind Med. 1985 Aug;42(8):517–524. doi: 10.1136/oem.42.8.517. [DOI] [PMC free article] [PubMed] [Google Scholar]
  212. Venables K. M., Dally M. B., Nunn A. J., Stevens J. F., Stephens R., Farrer N., Hunter J. V., Stewart M., Hughes E. G., Newman Taylor A. J. Smoking and occupational allergy in workers in a platinum refinery. BMJ. 1989 Oct 14;299(6705):939–942. doi: 10.1136/bmj.299.6705.939. [DOI] [PMC free article] [PubMed] [Google Scholar]
  213. Venables K. M., Davison A. G., Newman Taylor A. J. Consequences of occupational asthma. Respir Med. 1989 Sep;83(5):437–440. doi: 10.1016/s0954-6111(89)80078-2. [DOI] [PubMed] [Google Scholar]
  214. Venables K. M., Tee R. D., Hawkins E. R., Gordon D. J., Wale C. J., Farrer N. M., Lam T. H., Baxter P. J., Newman Taylor A. J. Laboratory animal allergy in a pharmaceutical company. Br J Ind Med. 1988 Oct;45(10):660–666. doi: 10.1136/oem.45.10.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  215. Venables K. M., Topping M. D., Howe W., Luczynska C. M., Hawkins R., Taylor A. J. Interaction of smoking and atopy in producing specific IgE antibody against a hapten protein conjugate. Br Med J (Clin Res Ed) 1985 Jan 19;290(6463):201–204. doi: 10.1136/bmj.290.6463.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  216. Venables K. M., Topping M. D., Nunn A. J., Howe W., Newman Taylor A. J. Immunologic and functional consequences of chemical (tetrachlorophthalic anhydride)-induced asthma after four years of avoidance of exposure. J Allergy Clin Immunol. 1987 Aug;80(2):212–218. doi: 10.1016/0091-6749(87)90131-x. [DOI] [PubMed] [Google Scholar]
  217. Venables K. M., Upton J. L., Hawkins E. R., Tee R. D., Longbottom J. L., Newman Taylor A. J. Smoking, atopy, and laboratory animal allergy. Br J Ind Med. 1988 Oct;45(10):667–671. doi: 10.1136/oem.45.10.667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  218. Weill H., Waddell L. C., Ziskind M. A study of workers exposed to detergent enzymes. JAMA. 1971 Jul 26;217(4):425–433. [PubMed] [Google Scholar]
  219. Wernfors M., Nielsen J., Schütz A., Skerfving S. Phthalic anhydride-induced occupational asthma. Int Arch Allergy Appl Immunol. 1986;79(1):77–82. doi: 10.1159/000233946. [DOI] [PubMed] [Google Scholar]
  220. Winck João C., Delgado Luís, Murta Rita, Vanzeller Manuela, Marques J. Agostinho. Cork workers' occupational asthma: lack of association with allergic sensitisation to fungi of the work environment. Int Arch Occup Environ Health. 2004 Jan 22;77(4):296–300. doi: 10.1007/s00420-003-0494-x. [DOI] [PubMed] [Google Scholar]
  221. Witmeur O., Wolf-Jürgensen P., Hoegh-Thomsen J., Rasmussen O. G., Wide L., Zachariae H. Medical experience in enzyme production. Acta Allergol. 1973 Oct;28(4):250–259. doi: 10.1111/j.1398-9995.1973.tb01445.x. [DOI] [PubMed] [Google Scholar]
  222. Young R. P., Barker R. D., Pile K. D., Cookson W. O., Taylor A. J. The association of HLA-DR3 with specific IgE to inhaled acid anhydrides. Am J Respir Crit Care Med. 1995 Jan;151(1):219–221. doi: 10.1164/ajrccm.151.1.7812558. [DOI] [PubMed] [Google Scholar]
  223. Zentner A., Jeep S., Wahl R., Kunkel G., Kleine-Tebbe J. Multiple IgE-mediated sensitizations to enzymes after occupational exposure: evaluation by skin prick test, RAST, and immunoblot. Allergy. 1997 Sep;52(9):928–934. doi: 10.1111/j.1398-9995.1997.tb01253.x. [DOI] [PubMed] [Google Scholar]
  224. Zock J. P., Brederode D., Heederik D. Between- and within-observer agreement for expert judgment of peak flow graphs from a working population. J Occup Environ Med. 1998 Nov;40(11):969–972. doi: 10.1097/00043764-199811000-00006. [DOI] [PubMed] [Google Scholar]
  225. de Bono J., Hudsmith L. Occupational asthma: a community based study. Occup Med (Lond) 1999 May;49(4):217–219. doi: 10.1093/occmed/49.4.217. [DOI] [PubMed] [Google Scholar]

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