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. 1999 Sep;75(887):521–526. doi: 10.1136/pgmj.75.887.521

Pancreatic cancer: any prospects for prevention?

A Hart 1
PMCID: PMC1741344  PMID: 10616684

Abstract

Primary prevention of pancreatic cancer and public health measures to reduce its incidence are dependent on data from epidemiological studies. Currently, the only definite risk factor is smoking, although a diet rich in fruit and vegetables may be protective. The K-ras mutation may have a role in diagnosis and screening.


Keywords: pancreatic cancer; epidemiology; risk factors; smoking; diet; alcohol

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Selected References

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  1. Alanen K. A., Joensuu H. Long-term survival after pancreatic adenocarcinoma--often a misdiagnosis? Br J Cancer. 1993 Nov;68(5):1004–1005. doi: 10.1038/bjc.1993.469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Armstrong B., Doll R. Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. Int J Cancer. 1975 Apr 15;15(4):617–631. doi: 10.1002/ijc.2910150411. [DOI] [PubMed] [Google Scholar]
  3. Bramhall S. R., Allum W. H., Jones A. G., Allwood A., Cummins C., Neoptolemos J. P. Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: an epidemiological study. Br J Surg. 1995 Jan;82(1):111–115. doi: 10.1002/bjs.1800820137. [DOI] [PubMed] [Google Scholar]
  4. Caldas C., Hahn S. A., Hruban R. H., Redston M. S., Yeo C. J., Kern S. E. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res. 1994 Jul 1;54(13):3568–3573. [PubMed] [Google Scholar]
  5. Carriaga M. T., Henson D. E. Liver, gallbladder, extrahepatic bile ducts, and pancreas. Cancer. 1995 Jan 1;75(1 Suppl):171–190. doi: 10.1002/1097-0142(19950101)75:1+<171::aid-cncr2820751306>3.0.co;2-2. [DOI] [PubMed] [Google Scholar]
  6. Doll R., Peto R., Wheatley K., Gray R., Sutherland I. Mortality in relation to smoking: 40 years' observations on male British doctors. BMJ. 1994 Oct 8;309(6959):901–911. doi: 10.1136/bmj.309.6959.901. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Everhart J., Wright D. Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis. JAMA. 1995 May 24;273(20):1605–1609. [PubMed] [Google Scholar]
  8. Farrow D. C., Davis S. Diet and the risk of pancreatic cancer in men. Am J Epidemiol. 1990 Sep;132(3):423–431. doi: 10.1093/oxfordjournals.aje.a115677. [DOI] [PubMed] [Google Scholar]
  9. Ferraroni M., Negri E., La Vecchia C., D'Avanzo B., Franceschi S. Socioeconomic indicators, tobacco and alcohol in the aetiology of digestive tract neoplasms. Int J Epidemiol. 1989 Sep;18(3):556–562. doi: 10.1093/ije/18.3.556. [DOI] [PubMed] [Google Scholar]
  10. Flanders T. Y., Foulkes W. D. Pancreatic adenocarcinoma: epidemiology and genetics. J Med Genet. 1996 Nov;33(11):889–898. doi: 10.1136/jmg.33.11.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Giovannucci E., Stampfer M. J., Colditz G., Rimm E. B., Willett W. C. Relationship of diet to risk of colorectal adenoma in men. J Natl Cancer Inst. 1992 Jan 15;84(2):91–98. doi: 10.1093/jnci/84.2.91. [DOI] [PubMed] [Google Scholar]
  12. Gordis L. Consumption of methylxanthine-containing beverages and risk of pancreatic cancer. Cancer Lett. 1990 Jun 30;52(1):1–12. doi: 10.1016/0304-3835(90)90070-e. [DOI] [PubMed] [Google Scholar]
  13. Gullo L., Pezzilli R., Morselli-Labate A. M., Italian Pancreatic Cancer Study Group Diabetes and the risk of pancreatic cancer. N Engl J Med. 1994 Jul 14;331(2):81–84. doi: 10.1056/NEJM199407143310203. [DOI] [PubMed] [Google Scholar]
  14. Hahn S. A., Schutte M., Hoque A. T., Moskaluk C. A., da Costa L. T., Rozenblum E., Weinstein C. L., Fischer A., Yeo C. J., Hruban R. H. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science. 1996 Jan 19;271(5247):350–353. doi: 10.1126/science.271.5247.350. [DOI] [PubMed] [Google Scholar]
  15. Hirayama T. Epidemiology of pancreatic cancer in Japan. Jpn J Clin Oncol. 1989 Sep;19(3):208–215. [PubMed] [Google Scholar]
  16. Howe G. R., Burch J. D. Nutrition and pancreatic cancer. Cancer Causes Control. 1996 Jan;7(1):69–82. doi: 10.1007/BF00115639. [DOI] [PubMed] [Google Scholar]
  17. Howe G. R., Friedenreich C. M., Jain M., Miller A. B. A cohort study of fat intake and risk of breast cancer. J Natl Cancer Inst. 1991 Mar 6;83(5):336–340. doi: 10.1093/jnci/83.5.336. [DOI] [PubMed] [Google Scholar]
  18. Howe G. R., Ghadirian P., Bueno de Mesquita H. B., Zatonski W. A., Baghurst P. A., Miller A. B., Simard A., Baillargeon J., de Waard F., Przewozniak K. A collaborative case-control study of nutrient intake and pancreatic cancer within the search programme. Int J Cancer. 1992 May 28;51(3):365–372. doi: 10.1002/ijc.2910510306. [DOI] [PubMed] [Google Scholar]
  19. Hruban R. H., van Mansfeld A. D., Offerhaus G. J., van Weering D. H., Allison D. C., Goodman S. N., Kensler T. W., Bose K. K., Cameron J. L., Bos J. L. K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol. 1993 Aug;143(2):545–554. [PMC free article] [PubMed] [Google Scholar]
  20. Karmody A. J., Kyle J. The association between carcinoma of the pancreas and diabetes mellitus. Br J Surg. 1969 May;56(5):362–364. doi: 10.1002/bjs.1800560512. [DOI] [PubMed] [Google Scholar]
  21. Lin R. S., Kessler I. I. A multifactorial model for pancreatic cancer in man. Epidemiologic evidence. JAMA. 1981 Jan 9;245(2):147–152. [PubMed] [Google Scholar]
  22. Lowenfels A. B., Maisonneuve P., Cavallini G., Ammann R. W., Lankisch P. G., Andersen J. R., Dimagno E. P., Andrén-Sandberg A., Domellöf L. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group. N Engl J Med. 1993 May 20;328(20):1433–1437. doi: 10.1056/NEJM199305203282001. [DOI] [PubMed] [Google Scholar]
  23. Lynch H. T., Fusaro L., Lynch J. F. Familial pancreatic cancer: a family study. Pancreas. 1992;7(5):511–515. doi: 10.1097/00006676-199209000-00001. [DOI] [PubMed] [Google Scholar]
  24. MacDermott R. P., Kramer P. Adenocarcinoma of the pancreas in four siblings. Gastroenterology. 1973 Jul;65(1):137–139. [PubMed] [Google Scholar]
  25. MacMahon B., Yen S., Trichopoulos D., Warren K., Nardi G. Coffee and cancer of the pancreas. N Engl J Med. 1981 Mar 12;304(11):630–633. doi: 10.1056/NEJM198103123041102. [DOI] [PubMed] [Google Scholar]
  26. Mack T. M., Peters J. M., Yu M. C., Hanisch R., Wright W. E., Henderson B. E. Pancreas cancer is unrelated to the workplace in Los Angeles. Am J Ind Med. 1985;7(3):253–266. doi: 10.1002/ajim.4700070307. [DOI] [PubMed] [Google Scholar]
  27. Mack T. M., Yu M. C., Hanisch R., Henderson B. E. Pancreas cancer and smoking, beverage consumption, and past medical history. J Natl Cancer Inst. 1986 Jan;76(1):49–60. [PubMed] [Google Scholar]
  28. Marshall J., Priore R., Haughey B., Rzepka T., Graham S. Spouse-subject interviews and the reliability of diet studies. Am J Epidemiol. 1980 Nov;112(5):675–683. doi: 10.1093/oxfordjournals.aje.a113040. [DOI] [PubMed] [Google Scholar]
  29. McMichael A. J., McCall M. G., Hartshorne J. M., Woodings T. L. Patterns of gastro-intestinal cancer in European migrants to Australia: the role of dietary change. Int J Cancer. 1980 Apr 15;25(4):431–437. doi: 10.1002/ijc.2910250402. [DOI] [PubMed] [Google Scholar]
  30. Mills P. K., Beeson W. L., Abbey D. E., Fraser G. E., Phillips R. L. Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists. Cancer. 1988 Jun 15;61(12):2578–2585. doi: 10.1002/1097-0142(19880615)61:12<2578::aid-cncr2820611232>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  31. Parkin D. M., Pisani P., Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985. Int J Cancer. 1993 Jun 19;54(4):594–606. doi: 10.1002/ijc.2910540413. [DOI] [PubMed] [Google Scholar]
  32. Permert J., Ihse I., Jorfeldt L., von Schenck H., Arnquist H. J., Larsson J. Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer. Br J Surg. 1993 Aug;80(8):1047–1050. doi: 10.1002/bjs.1800800841. [DOI] [PubMed] [Google Scholar]
  33. Permert J., Larsson J., Westermark G. T., Herrington M. K., Christmanson L., Pour P. M., Westermark P., Adrian T. E. Islet amyloid polypeptide in patients with pancreatic cancer and diabetes. N Engl J Med. 1994 Feb 3;330(5):313–318. doi: 10.1056/NEJM199402033300503. [DOI] [PubMed] [Google Scholar]
  34. Riboli E. Nutrition and cancer: background and rationale of the European Prospective Investigation into Cancer and Nutrition (EPIC). Ann Oncol. 1992 Dec;3(10):783–791. doi: 10.1093/oxfordjournals.annonc.a058097. [DOI] [PubMed] [Google Scholar]
  35. Rivenson A., Hoffmann D., Prokopczyk B., Amin S., Hecht S. S. Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. Cancer Res. 1988 Dec 1;48(23):6912–6917. [PubMed] [Google Scholar]
  36. Rogot E., Murray J. L. Smoking and causes of death among U.S. veterans: 16 years of observation. Public Health Rep. 1980 May-Jun;95(3):213–222. [PMC free article] [PubMed] [Google Scholar]
  37. Ross A. H., Smith M. A., Anderson J. R., Small W. P. Late mortality after surgery for peptic ulcer. N Engl J Med. 1982 Aug 26;307(9):519–522. doi: 10.1056/NEJM198208263070902. [DOI] [PubMed] [Google Scholar]
  38. Shibata A., Mack T. M., Paganini-Hill A., Ross R. K., Henderson B. E. A prospective study of pancreatic cancer in the elderly. Int J Cancer. 1994 Jul 1;58(1):46–49. doi: 10.1002/ijc.2910580109. [DOI] [PubMed] [Google Scholar]
  39. Whittemore A. S., Paffenbarger R. S., Jr, Anderson K., Halpern J. Early precursors of pancreatic cancer in college men. J Chronic Dis. 1983;36(3):251–256. doi: 10.1016/0021-9681(83)90059-0. [DOI] [PubMed] [Google Scholar]
  40. Willett W. C., Stampfer M. J., Colditz G. A., Rosner B. A., Speizer F. E. Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N Engl J Med. 1990 Dec 13;323(24):1664–1672. doi: 10.1056/NEJM199012133232404. [DOI] [PubMed] [Google Scholar]
  41. Willett W., Stampfer M. J. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol. 1986 Jul;124(1):17–27. doi: 10.1093/oxfordjournals.aje.a114366. [DOI] [PubMed] [Google Scholar]
  42. Wynder E. L., Hall N. E., Polansky M. Epidemiology of coffee and pancreatic cancer. Cancer Res. 1983 Aug;43(8):3900–3906. [PubMed] [Google Scholar]
  43. Wynder E. L., Mabuchi K., Maruchi N., Fortner J. G. Epidemiology of cancer of the pancreas. J Natl Cancer Inst. 1973 Mar;50(3):645–667. doi: 10.1093/jnci/50.3.645. [DOI] [PubMed] [Google Scholar]
  44. van den Brandt P. A., Goldbohm R. A., van 't Veer P., Volovics A., Hermus R. J., Sturmans F. A large-scale prospective cohort study on diet and cancer in The Netherlands. J Clin Epidemiol. 1990;43(3):285–295. doi: 10.1016/0895-4356(90)90009-e. [DOI] [PubMed] [Google Scholar]

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