Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1996 Jul;64(7):2804–2807. doi: 10.1128/iai.64.7.2804-2807.1996

Role of intercellular adhesion molecule 1 in pathogenesis of staphylococcal arthritis and in host defense against staphylococcal bacteremia.

M Verdrengh 1, T A Springer 1, J C Gutierrez-Ramos 1, A Tarkowski 1
PMCID: PMC174143  PMID: 8698512

Abstract

Intercellular adhesion molecule 1 (ICAM-1) is a member of the immunoglobulin superfamily that interacts with two integrins, LFA-1 and Mac-1. These interactions are critical for leukocyte extravasation into inflamed tissue. To assess the role of ICAM-1 expression in the pathogenesis of bacterial infection, homozygously mutant mice lacking the ICAM-1 gene were exposed to Staphylococcus aureus. Within 6 days after inoculation 50% of the animals in the ICAM-1(-/-) group, but none of the controls, had died. Despite the high level of mortality, ICAM-1(-/-) mice developed less frequent and less severe arthritis than their wild-type littermates. In agreement, normal mice inoculated with staphylococci and administered anti-ICAM-1 antibodies exhibited a higher frequency of mortality but less severe arthritis than the controls. Our results indicate that ICAM-1 on the one hand provides protection against systemic disease but on the other hand aggravates the local disease manifestation.

Full Text

The Full Text of this article is available as a PDF (230.7 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abdelnour A., Bremell T., Holmdahl R., Tarkowski A. Clonal expansion of T lymphocytes causes arthritis and mortality in mice infected with toxic shock syndrome toxin-1-producing staphylococci. Eur J Immunol. 1994 May;24(5):1161–1166. doi: 10.1002/eji.1830240523. [DOI] [PubMed] [Google Scholar]
  2. Abdelnour A., Bremell T., Holmdahl R., Tarkowski A. Role of T lymphocytes in experimental Staphylococcus aureus arthritis. Scand J Immunol. 1994 Apr;39(4):403–408. doi: 10.1111/j.1365-3083.1994.tb03392.x. [DOI] [PubMed] [Google Scholar]
  3. Abdelnour A., Bremell T., Tarkowski A. Toxic shock syndrome toxin 1 contributes to the arthritogenicity of Staphylococcus aureus. J Infect Dis. 1994 Jul;170(1):94–99. doi: 10.1093/infdis/170.1.94. [DOI] [PubMed] [Google Scholar]
  4. Abdelnour A., Tarkowski A. Polyclonal B-cell activation by an arthritogenic Staphylococcus aureus strain: contribution of T-cells and monokines. Cell Immunol. 1993 Apr 1;147(2):279–293. doi: 10.1006/cimm.1993.1069. [DOI] [PubMed] [Google Scholar]
  5. Bremell T., Holmdahl R., Tarkowski A. Protective role of sialophorin (CD43)-expressing cells in experimental Staphylococcus aureus infection. Infect Immun. 1994 Oct;62(10):4637–4640. doi: 10.1128/iai.62.10.4637-4640.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Bremell T., Lange S., Holmdahl R., Rydén C., Hansson G. K., Tarkowski A. Immunopathological features of rat Staphylococcus aureus arthritis. Infect Immun. 1994 Jun;62(6):2334–2344. doi: 10.1128/iai.62.6.2334-2344.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bremell T., Lange S., Svensson L., Jennische E., Gröndahl K., Carlsten H., Tarkowski A. Outbreak of spontaneous staphylococcal arthritis and osteitis in mice. Arthritis Rheum. 1990 Nov;33(11):1739–1744. doi: 10.1002/art.1780331120. [DOI] [PubMed] [Google Scholar]
  8. Bremell T., Lange S., Yacoub A., Rydén C., Tarkowski A. Experimental Staphylococcus aureus arthritis in mice. Infect Immun. 1991 Aug;59(8):2615–2623. doi: 10.1128/iai.59.8.2615-2623.1991. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Bremell T., Tarkowski A. Preferential induction of septic arthritis and mortality by superantigen-producing staphylococci. Infect Immun. 1995 Oct;63(10):4185–4187. doi: 10.1128/iai.63.10.4185-4187.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dang L. H., Michalek M. T., Takei F., Benaceraff B., Rock K. L. Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants. J Immunol. 1990 Jun 1;144(11):4082–4091. [PubMed] [Google Scholar]
  11. Davis L. S., Kavanaugh A. F., Nichols L. A., Lipsky P. E. Induction of persistent T cell hyporesponsiveness in vivo by monoclonal antibody to ICAM-1 in patients with rheumatoid arthritis. J Immunol. 1995 Apr 1;154(7):3525–3537. [PubMed] [Google Scholar]
  12. Dustin M. L., Rothlein R., Bhan A. K., Dinarello C. A., Springer T. A. Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J Immunol. 1986 Jul 1;137(1):245–254. [PubMed] [Google Scholar]
  13. Hogg N., Bates P. A., Harvey J. Structure and function of intercellular adhesion molecule-1. Chem Immunol. 1991;50:98–115. [PubMed] [Google Scholar]
  14. Iigo Y., Takashi T., Tamatani T., Miyasaka M., Higashida T., Yagita H., Okumura K., Tsukada W. ICAM-1-dependent pathway is critically involved in the pathogenesis of adjuvant arthritis in rats. J Immunol. 1991 Dec 15;147(12):4167–4171. [PubMed] [Google Scholar]
  15. Kakimoto K., Nakamura T., Ishii K., Takashi T., Iigou H., Yagita H., Okumura K., Onoue K. The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis. Cell Immunol. 1992 Jul;142(2):326–337. doi: 10.1016/0008-8749(92)90294-y. [DOI] [PubMed] [Google Scholar]
  16. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  17. Mikecz K., Brennan F. R., Kim J. H., Glant T. T. The role of adhesion molecules in the development of autoimmune arthritis. Scand J Rheumatol Suppl. 1995;101:99–106. doi: 10.3109/03009749509100908. [DOI] [PubMed] [Google Scholar]
  18. Xu H., Gonzalo J. A., St Pierre Y., Williams I. R., Kupper T. S., Cotran R. S., Springer T. A., Gutierrez-Ramos J. C. Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med. 1994 Jul 1;180(1):95–109. doi: 10.1084/jem.180.1.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Zhao Y. X., Abdelnour A., Holmdahl R., Tarkowski A. Mice with the xid B cell defect are less susceptible to developing Staphylococcus aureus-induced arthritis. J Immunol. 1995 Aug 15;155(4):2067–2076. [PubMed] [Google Scholar]
  20. Zhao Y. X., Abdelnour A., Ljungdahl A., Olsson T., Tarkowski A. Patterns of interferon-gamma mRNA expression in toxic shock syndrome toxin-1 expanded V beta 11+ T lymphocytes. Cell Immunol. 1995 Mar;161(1):28–33. doi: 10.1006/cimm.1995.1005. [DOI] [PubMed] [Google Scholar]
  21. Zhao Y. X., Tarkowski A. Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis. J Immunol. 1995 Dec 15;155(12):5736–5742. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES