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. 1996 Jul;64(7):2821–2823. doi: 10.1128/iai.64.7.2821-2823.1996

T- and B-lymphocyte-independent formation of alveolar macrophage-derived multinucleated giant cells in murine Pneumocystis carinii pneumonia.

R Hanano 1, K Reifenberg 1, S H Kaufmann 1
PMCID: PMC174147  PMID: 8698516

Abstract

Multinucleated giant cells developed in Pneumocystis carinii-diseased gene disruption mutant mice deficient in major histocompatibility complex class II molecules, T-cell receptor alpha beta cells, or all mature T and B lymphocytes. These findings demonstrate lymphocyte-independent fusion of alveolar macrophages under morbid conditions. Pulmonary parasite burden seems to be a decisive factor in multinucleation.

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Selected References

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