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. 1996 Jul;64(7):2850–2852. doi: 10.1128/iai.64.7.2850-2852.1996

Interleukin-10 protects neonatal mice from lethal group B streptococcal infection.

V Cusumano 1, F Genovese 1, G Mancuso 1, M Carbone 1, M T Fera 1, G Teti 1
PMCID: PMC174154  PMID: 8698523

Abstract

We investigated the role of interleukin-10 (IL-10) in a neonatal mouse model of lethal group B streptococci (GBS) sepsis. Plasma IL-10 levels significantly increased at 24 and 48 h after GBS inoculation. Neutralization of IL-10 with specific antibodies had no effect on lethality. Administration of recombinant IL-10 at 20 or 4 h before challenge, but not at later times, resulted in decreased tumor necrosis factor alpha levels and improved survival. IL-10 could be potentially useful for the treatment of GBS sepsis.

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Selected References

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