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. 2000 Sep;76(899):569–573. doi: 10.1136/pmj.76.899.569

Frequency of proteinuria in type 2 diabetes mellitus seen at a diabetes centre in southern India

V Mohan 1, R Meera 1, G Premalatha 1, R Deepa 1, P Miranda 1, M Rema 1
PMCID: PMC1741744  PMID: 10964123

Abstract

The frequency of proteinuria was assessed in a cohort of 1848 diabetic patients attending a diabetes centre in south India. A total of 127 (6.9%) patients had evidence of macroproteinuria and 49 (2.5%) patients had microproteinuria. Thus overall 9.4% of patients had diabetes related proteinuria. In addition, 70 patients (3.8%) had evidence of proteinuria with no evidence of retinopathy. The frequency of both microproteinuria and macroproteinuria increased linearly with duration of diabetes. Multiple logistic regression analysis showed that duration of diabetes, serum creatinine, and glycated haemoglobin were risk factors for macroproteinuria.


Keywords: diabetic nephropathy; type 2 diabetes; south India

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Selected References

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  1. Allawi J., Rao P. V., Gilbert R., Scott G., Jarrett R. J., Keen H., Viberti G. C., Mather H. M. Microalbuminuria in non-insulin-dependent diabetes: its prevalence in Indian compared with Europid patients. Br Med J (Clin Res Ed) 1988 Feb 13;296(6620):462–464. doi: 10.1136/bmj.296.6620.462. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Andersen A. R., Christiansen J. S., Andersen J. K., Kreiner S., Deckert T. Diabetic nephropathy in Type 1 (insulin-dependent) diabetes: an epidemiological study. Diabetologia. 1983 Dec;25(6):496–501. doi: 10.1007/BF00284458. [DOI] [PubMed] [Google Scholar]
  3. Borch-Johnsen K., Andersen P. K., Deckert T. The effect of proteinuria on relative mortality in type 1 (insulin-dependent) diabetes mellitus. Diabetologia. 1985 Aug;28(8):590–596. doi: 10.1007/BF00281993. [DOI] [PubMed] [Google Scholar]
  4. Burden A. C., McNally P. G., Feehally J., Walls J. Increased incidence of end-stage renal failure secondary to diabetes mellitus in Asian ethnic groups in the United Kingdom. Diabet Med. 1992 Aug-Sep;9(7):641–645. doi: 10.1111/j.1464-5491.1992.tb01860.x. [DOI] [PubMed] [Google Scholar]
  5. Collins V. R., Dowse G. K., Plehwe W. E., Imo T. T., Toelupe P. M., Taylor H. R., Zimmet P. Z. High prevalence of diabetic retinopathy and nephropathy in Polynesians of Western Samoa. Diabetes Care. 1995 Aug;18(8):1140–1149. doi: 10.2337/diacare.18.8.1140. [DOI] [PubMed] [Google Scholar]
  6. Fabre J., Balant L. P., Dayer P. G., Fox H. M., Vernet A. T. The kidney in maturity onset diabetes mellitus: a clinical study of 510 patients. Kidney Int. 1982 May;21(5):730–738. doi: 10.1038/ki.1982.90. [DOI] [PubMed] [Google Scholar]
  7. John G. T., Date A., Korula A., Jeyaseelan L., Shastry J. C., Jacob C. K. Nondiabetic renal disease in noninsulin-dependent diabetics in a south Indian Hospital. Nephron. 1994;67(4):441–443. doi: 10.1159/000188019. [DOI] [PubMed] [Google Scholar]
  8. John L., Rao P. S., Kanagasabapathy A. S. Prevalence of diabetic nephropathy in non-insulin dependent diabetics. Indian J Med Res. 1991 Feb;94:24–29. [PubMed] [Google Scholar]
  9. King H., Aubert R. E., Herman W. H. Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projections. Diabetes Care. 1998 Sep;21(9):1414–1431. doi: 10.2337/diacare.21.9.1414. [DOI] [PubMed] [Google Scholar]
  10. Klein R., Klein B. E., Moss S. E. Incidence of gross proteinuria in older-onset diabetes. A population-based perspective. Diabetes. 1993 Mar;42(3):381–389. doi: 10.2337/diab.42.3.381. [DOI] [PubMed] [Google Scholar]
  11. Krolewski A. S., Warram J. H., Christlieb A. R., Busick E. J., Kahn C. R. The changing natural history of nephropathy in type I diabetes. Am J Med. 1985 May;78(5):785–794. doi: 10.1016/0002-9343(85)90284-0. [DOI] [PubMed] [Google Scholar]
  12. Marshall S. M., Alberti K. G. Comparison of the prevalence and associated features of abnormal albumin excretion in insulin-dependent and non-insulin-dependent diabetes. Q J Med. 1989 Jan;70(261):61–71. [PubMed] [Google Scholar]
  13. Mather H. M., Chaturvedi N., Kehely A. M. Comparison of prevalence and risk factors for microalbuminuria in South Asians and Europeans with type 2 diabetes mellitus. Diabet Med. 1998 Aug;15(8):672–677. doi: 10.1002/(SICI)1096-9136(199808)15:8<672::AID-DIA648>3.0.CO;2-3. [DOI] [PubMed] [Google Scholar]
  14. McKeigue P. M., Miller G. J., Marmot M. G. Coronary heart disease in south Asians overseas: a review. J Clin Epidemiol. 1989;42(7):597–609. doi: 10.1016/0895-4356(89)90002-4. [DOI] [PubMed] [Google Scholar]
  15. Mogensen C. E. Microalbuminuria predicts clinical proteinuria and early mortality in maturity-onset diabetes. N Engl J Med. 1984 Feb 9;310(6):356–360. doi: 10.1056/NEJM198402093100605. [DOI] [PubMed] [Google Scholar]
  16. Mohan V., Premalatha G., Sastry N. G. Peripheral vascular disease in non-insulin-dependent diabetes mellitus in south India. Diabetes Res Clin Pract. 1995 Mar;27(3):235–240. doi: 10.1016/0168-8227(95)01048-i. [DOI] [PubMed] [Google Scholar]
  17. Mohan V., Ramachandran A., Snehalatha C., Mohan R., Bharani G., Viswanathan M. High prevalence of maturity-onset diabetes of the young (MODY) among Indians. Diabetes Care. 1985 Jul-Aug;8(4):371–374. doi: 10.2337/diacare.8.4.371. [DOI] [PubMed] [Google Scholar]
  18. Olsen S., Mogensen C. E. How often is NIDDM complicated with non-diabetic renal disease? An analysis of renal biopsies and the literature. Diabetologia. 1996 Dec;39(12):1638–1645. doi: 10.1007/s001250050628. [DOI] [PubMed] [Google Scholar]
  19. Ramachandran A., Jali M. V., Mohan V., Snehalatha C., Viswanathan M. High prevalence of diabetes in an urban population in south India. BMJ. 1988 Sep 3;297(6648):587–590. doi: 10.1136/bmj.297.6648.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Ramachandran A., Mohan V., Kumaravel T. S., Velmurugendran C. U., Snehalatha C., Chinnikrishnudu M., Viswanathan M. Peripheral neuropathy in tropical pancreatic diabetes. Acta Diabetol Lat. 1986 Apr-Jun;23(2):135–140. doi: 10.1007/BF02624673. [DOI] [PubMed] [Google Scholar]
  21. Ramachandran A., Snehalatha C., Latha E., Vijay V., Viswanathan M. Rising prevalence of NIDDM in an urban population in India. Diabetologia. 1997 Feb;40(2):232–237. doi: 10.1007/s001250050668. [DOI] [PubMed] [Google Scholar]
  22. Rema M., Ponnaiya M., Mohan V. Prevalence of retinopathy in non insulin dependent diabetes mellitus at a diabetes centre in southern India. Diabetes Res Clin Pract. 1996 Sep;34(1):29–36. doi: 10.1016/s0168-8227(96)01327-7. [DOI] [PubMed] [Google Scholar]
  23. Samanta A., Burden A. C., Feehally J., Walls J. Diabetic renal disease: differences between Asian and white patients. Br Med J (Clin Res Ed) 1986 Aug 9;293(6543):366–367. doi: 10.1136/bmj.293.6543.366-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Schmitz A., Vaeth M. Microalbuminuria: a major risk factor in non-insulin-dependent diabetes. A 10-year follow-up study of 503 patients. Diabet Med. 1988 Mar;5(2):126–134. doi: 10.1111/j.1464-5491.1988.tb00958.x. [DOI] [PubMed] [Google Scholar]
  25. Snehalatha C., Ramachandran A., Mohan V., Viswanathan M. Pancreatic beta cell response in insulin treated NIDDM patients limitations of a random C-peptide measurement. Diabete Metab. 1987 Feb;13(1):27–30. [PubMed] [Google Scholar]
  26. Stephenson J. M., Kenny S., Stevens L. K., Fuller J. H., Lee E. Proteinuria and mortality in diabetes: the WHO Multinational Study of Vascular Disease in Diabetes. Diabet Med. 1995 Feb;12(2):149–155. doi: 10.1111/j.1464-5491.1995.tb00446.x. [DOI] [PubMed] [Google Scholar]
  27. Tung P., Levin S. R. Nephropathy in non-insulin-dependent diabetes mellitus. Am J Med. 1988 Nov 28;85(5A):131–136. doi: 10.1016/0002-9343(88)90405-6. [DOI] [PubMed] [Google Scholar]
  28. Vijay V., Snehalatha C., Ramachandran A., Viswanathan M. Prevalence of proteinuria in non-insulin dependent diabetes. J Assoc Physicians India. 1994 Oct;42(10):792–794. [PubMed] [Google Scholar]
  29. Viswanathan M., Mohan V., Snehalatha C., Ramachandran A. High prevalence of type 2 (non-insulin-dependent) diabetes among the offspring of conjugal type 2 diabetic parents in India. Diabetologia. 1985 Dec;28(12):907–910. doi: 10.1007/BF00703134. [DOI] [PubMed] [Google Scholar]
  30. Viswanathan V. V., Snehalatha C., Ramachandran A., Viswanathan M. Proteinuria in NIDDM in south India: analysis of predictive factors. Diabetes Res Clin Pract. 1995 Apr;28(1):41–46. doi: 10.1016/0168-8227(95)01057-k. [DOI] [PubMed] [Google Scholar]
  31. Zelmanovitz T., Gross J. L., Oliveira J., de Azevedo M. J. Proteinuria is still useful for the screening and diagnosis of overt diabetic nephropathy. Diabetes Care. 1998 Jul;21(7):1076–1079. doi: 10.2337/diacare.21.7.1076. [DOI] [PubMed] [Google Scholar]

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