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. 2001 Nov;77(913):708–712. doi: 10.1136/pmj.77.913.708

Adenocarcinoma of the lung in Chinese patients: a revisit and some perspectives from the literature

B Lam 1, W Lam 1, C Lam 1, G Ooi 1, J Ho 1, M Wong 1, K Tsang 1
PMCID: PMC1742164  PMID: 11677280

Abstract

AIM—To establish an updated clinical profile of adenocarcinoma of the lung.
DESIGN—Retrospective review of clinical charts, chest radiography, and computed tomography of consecutive patients who attended Queen Mary Hospital in Hong Kong between June 1995 and December 1997.
RESULTS—In the 115 patients studied, 13% were <40 years of age (33.3% ever smokers). Haemoptysis is more common among patients with early disease, while finger clubbing was detected more commonly among smokers and ex-smokers. Most (98.3%) patients had abnormal chest radiology including presence of mass lesion, pleural effusion, collapse/consolidation, and effusion. Patients with adenocarcinoma were significantly more likely to be younger, female, in advanced disease (stage IIIB and IV), non-smoker, and symptomatic on presentation (p<0.05) than those with squamous cell lung cancer (n=128).
CONCLUSION—The clinical profile of Chinese adenocarcinoma patients should help clinicians in the diagnosis and management of these patients.


Keywords: lung cancer; adenocarcinoma; clinical profiles

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Selected References

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  1. Beamis J. F., Jr, Stein A., Andrews J. L., Jr Changing epidemiology of lung cancer. Increasing incidence in women. Med Clin North Am. 1975 Mar;59(2):315–325. doi: 10.1016/s0025-7125(16)32034-x. [DOI] [PubMed] [Google Scholar]
  2. Capewell S., Wathen C. G., Sankaran R., Sudlow M. F. Lung cancer in young patients. Respir Med. 1992 Nov;86(6):499–502. doi: 10.1016/s0954-6111(96)80010-2. [DOI] [PubMed] [Google Scholar]
  3. Chan A. S., Lam W. K., Wong M. P., Fu K. H., Lee J., Yew W. W., Chiu S. W., Lung M. L. Chromosomal 11 alterations in non-small-cell lung carcinomas in Hong Kong. Lung Cancer. 1996 Aug;15(1):51–65. doi: 10.1016/0169-5002(96)00570-3. [DOI] [PubMed] [Google Scholar]
  4. Cooper D. A., Crane A. R., Boucot K. R. Primary carcinoma of the lung in nonsmokers. Arch Environ Health. 1968 Mar;16(3):398–400. doi: 10.1080/00039896.1968.10665077. [DOI] [PubMed] [Google Scholar]
  5. Dev D., Capewell S., Sankaran R., Lamb D., Sudlow M. F. Adenocarcinoma of the lung--clinical features and survival. Respir Med. 1996 Jul;90(6):333–337. doi: 10.1016/s0954-6111(96)90128-6. [DOI] [PubMed] [Google Scholar]
  6. Doll R., Peto R. Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J. 1976 Dec 25;2(6051):1525–1536. doi: 10.1136/bmj.2.6051.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Doll R., Peto R. The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst. 1981 Jun;66(6):1191–1308. [PubMed] [Google Scholar]
  8. Ge H., Lam W. K., Lee J., Wong M. P., Fu K. H., Yew W. W., Lung M. L. Detection and evaluation of p53 intron 2 polymorphism in lung carcinomas in Hong Kong. Int J Cancer. 1996 Apr 22;69(2):120–124. doi: 10.1002/(SICI)1097-0215(19960422)69:2<120::AID-IJC9>3.0.CO;2-2. [DOI] [PubMed] [Google Scholar]
  9. Ge H., Lam W. K., Lee J., Wong M. P., Yew W. W., Lung M. L. Analysis of L-myc and GSTM1 genotypes in Chinese non-small cell lung carcinoma patients. Lung Cancer. 1996 Nov;15(3):355–366. doi: 10.1016/0169-5002(95)00598-6. [DOI] [PubMed] [Google Scholar]
  10. Ge H., Wong M. P., Lam W. K., Lee J., Fu K. H., Yew W. W., Lung M. L. p53 intron 2 genotypes detected in normal specimens and lung carcinomas in Hong Kong. Oncol Rep. 1998 Sep-Oct;5(5):1265–1267. doi: 10.3892/or.5.5.1265. [DOI] [PubMed] [Google Scholar]
  11. Kabat G. C., Wynder E. L. Lung cancer in nonsmokers. Cancer. 1984 Mar 1;53(5):1214–1221. doi: 10.1002/1097-0142(19840301)53:5<1214::aid-cncr2820530532>3.0.co;2-8. [DOI] [PubMed] [Google Scholar]
  12. Kennedy A. Relationship between cigarette smoking and histological type of lung cancer in women. Thorax. 1973 Mar;28(2):204–208. doi: 10.1136/thx.28.2.204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kit L. W. Why is lung cancer common in non-smoking women in Hong Kong: from epidemiologic to molecular studies. Chin Med J (Engl) 1997 Jun;110(6):420–424. [PubMed] [Google Scholar]
  14. Koo L. C., Ho J. H., Saw D., Ho C. Y. Measurements of passive smoking and estimates of lung cancer risk among non-smoking Chinese females. Int J Cancer. 1987 Feb 15;39(2):162–169. doi: 10.1002/ijc.2910390207. [DOI] [PubMed] [Google Scholar]
  15. Lam K. Y., Fu K. H., Wong M. P., Wang E. P. Significant changes in the distribution of histologic types of lung cancer in Hong Kong. Pathology. 1993 Apr;25(2):103–105. doi: 10.3109/00313029309084779. [DOI] [PubMed] [Google Scholar]
  16. Lam T. H., Kung I. T., Wong C. M., Lam W. K., Kleevens J. W., Saw D., Hsu C., Seneviratne S., Lam S. Y., Lo K. K. Smoking, passive smoking and histological types in lung cancer in Hong Kong Chinese women. Br J Cancer. 1987 Nov;56(5):673–678. doi: 10.1038/bjc.1987.264. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Lam W. K., Hawkins B. R., Kung I. T., So S. Y. No association between HLA antigens and adenocarcinoma of the lung in non-smoking Chinese women in Hong Kong. Br J Dis Chest. 1986 Oct;80(4):370–374. doi: 10.1016/0007-0971(86)90090-2. [DOI] [PubMed] [Google Scholar]
  18. Lam W. K., So S. Y., Yu D. Y. Clinical features of bronchogenic carcinoma in Hong Kong. Review of 480 patients. Cancer. 1983 Jul 15;52(2):369–376. doi: 10.1002/1097-0142(19830715)52:2<369::aid-cncr2820520231>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
  19. Landis S. H., Murray T., Bolden S., Wingo P. A. Cancer statistics, 1999. CA Cancer J Clin. 1999 Jan-Feb;49(1):8-31, 1. doi: 10.3322/canjclin.49.1.8. [DOI] [PubMed] [Google Scholar]
  20. Lung M. L., Wong M. P., Skaanild M. T., Fok C. L., Lam W. K., Yew W. W. p53 mutations in non-small cell lung carcinomas in Hong Kong. Chest. 1996 Mar;109(3):718–726. doi: 10.1378/chest.109.3.718. [DOI] [PubMed] [Google Scholar]
  21. Lung M. L., Wong M., Lam W. K., Lau K. S., Kwan S., Fu K. H., Cheung H., Yew W. W. Incidence of ras oncogene activation in lung carcinomas in Hong Kong. Cancer. 1992 Aug 15;70(4):760–763. doi: 10.1002/1097-0142(19920815)70:4<760::aid-cncr2820700407>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
  22. McDuffie H. H., Klaassen D. J., Dosman J. A. Characteristics of patients with primary lung cancer diagnosed at age of 50 years or younger. Chest. 1989 Dec;96(6):1298–1301. doi: 10.1378/chest.96.6.1298. [DOI] [PubMed] [Google Scholar]
  23. Putnam J. S. Lung carcinoma in young adults. JAMA. 1977 Jul 4;238(1):35–36. [PubMed] [Google Scholar]
  24. Rostad H., Vale J. R., Nesthus I. Lung cancer. Symptoms, signs and diagnostic criteria. Scand J Respir Dis. 1979 Aug;60(4):184–190. [PubMed] [Google Scholar]
  25. Wynder E. L., Berg J. W. Cancer of the lung among nonsmokers. Special reference to histologic patterns. Cancer. 1967 Jul;20(7):1161–1172. doi: 10.1002/1097-0142(196707)20:7<1161::aid-cncr2820200720>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  26. Yesner R., Gelfman N. A., Feinstein A. R. A reappraisal of histopathology in lung cancer and correlation of cell types with antecedent cigarette smoking. Am Rev Respir Dis. 1973 May;107(5):790–797. doi: 10.1164/arrd.1973.107.5.790. [DOI] [PubMed] [Google Scholar]
  27. Yesner R. Pathogenesis and pathology. Clin Chest Med. 1993 Mar;14(1):17–30. [PubMed] [Google Scholar]
  28. el-Torky M., el-Zeky F., Hall J. C. Significant changes in the distribution of histologic types of lung cancer. A review of 4928 cases. Cancer. 1990 May 15;65(10):2361–2367. doi: 10.1002/1097-0142(19900515)65:10<2361::aid-cncr2820651034>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]

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