Abstract
For patients with suboptimal relief from lifestyle modifications, acid suppressive therapy remains a cornerstone of treatment for gastro-oesophageal reflux disease (GORD). While a great deal of attention is focused on complications of GORD, adequate symptom relief remains an important and practical therapeutic goal. Adequate symptom relief is an achievable and easily measurable endpoint that both restores quality of life and prevents many potential complications.
Full Text
The Full Text of this article is available as a PDF (113.0 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- An evidence-based appraisal of reflux disease management--the Genval Workshop Report. Gut. 1999 Apr;44 (Suppl 2):S1–16. doi: 10.1136/gut.44.2008.s1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barbezat G. O., Schlup M., Lubcke R. Omeprazole therapy decreases the need for dilatation of peptic oesophageal strictures. Aliment Pharmacol Ther. 1999 Aug;13(8):1041–1045. doi: 10.1046/j.1365-2036.1999.00582.x. [DOI] [PubMed] [Google Scholar]
- Bardhan K. D., Müller-Lissner S., Bigard M. A., Bianchi Porro G., Ponce J., Hosie J., Scott M., Weir D. G., Gillon K. R., Peacock R. A. Symptomatic gastro-oesophageal reflux disease: double blind controlled study of intermittent treatment with omeprazole or ranitidine. The European Study Group. BMJ. 1999 Feb 20;318(7182):502–507. doi: 10.1136/bmj.318.7182.502. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blustein P. K., Beck P. L., Meddings J. B., Van Rosendaal G. M., Bailey R. J., Lalor E., Thomson A. B., Verhoef M. J., Sutherland L. R. The utility of endoscopy in the management of patients with gastroesophageal reflux symptoms. Am J Gastroenterol. 1998 Dec;93(12):2508–2512. doi: 10.1111/j.1572-0241.1998.00594.x. [DOI] [PubMed] [Google Scholar]
- Carlsson R., Dent J., Watts R., Riley S., Sheikh R., Hatlebakk J., Haug K., de Groot G., van Oudvorst A., Dalväg A. Gastro-oesophageal reflux disease in primary care: an international study of different treatment strategies with omeprazole. International GORD Study Group. Eur J Gastroenterol Hepatol. 1998 Feb;10(2):119–124. [PubMed] [Google Scholar]
- Chiba N. Proton pump inhibitors in acute healing and maintenance of erosive or worse esophagitis: a systematic overview. Can J Gastroenterol. 1997 Sep;11 (Suppl B):66B–73B. [PubMed] [Google Scholar]
- Dimenäs E. Methodological aspects of evaluation of Quality of Life in upper gastrointestinal diseases. Scand J Gastroenterol Suppl. 1993;199:18–21. [PubMed] [Google Scholar]
- Farley A., Wruble L. D., Humphries T. J. Rabeprazole versus ranitidine for the treatment of erosive gastroesophageal reflux disease: a double-blind, randomized clinical trial. Raberprazole Study Group. Am J Gastroenterol. 2000 Aug;95(8):1894–1899. doi: 10.1111/j.1572-0241.2000.02233.x. [DOI] [PubMed] [Google Scholar]
- Glise H., Hallerbäck B., Johansson B. Quality of Life assessments in the evaluation of gastroesophageal reflux and peptic ulcer disease before, during and after treatment. Scand J Gastroenterol Suppl. 1995;208:133–135. doi: 10.3109/00365529509107775. [DOI] [PubMed] [Google Scholar]
- Hatlebakk J. G., Berstad A., Carling L., Svedberg L. E., Unge P., Ekström P., Halvorsen L., Stallemo A., Hovdenak N., Trondstad R. Lansoprazole versus omeprazole in short-term treatment of reflux oesophagitis. Results of a Scandinavian multicentre trial. Scand J Gastroenterol. 1993 Mar;28(3):224–228. doi: 10.3109/00365529309096076. [DOI] [PubMed] [Google Scholar]
- Howden C. W., Henning J. M., Huang B., Lukasik N., Freston J. W. Management of heartburn in a large, randomized, community-based study: comparison of four therapeutic strategies. Am J Gastroenterol. 2001 Jun;96(6):1704–1710. doi: 10.1111/j.1572-0241.2001.03861.x. [DOI] [PubMed] [Google Scholar]
- Johannessen T., Kristensen P. On-demand therapy in gastroesophageal reflux disease: a comparison of the early effects of single doses of fast-dissolving famotidine wafers and ranitidine tablets. Clin Ther. 1997 Jan-Feb;19(1):73–81. doi: 10.1016/s0149-2918(97)80074-4. [DOI] [PubMed] [Google Scholar]
- Lagergren J., Bergström R., Lindgren A., Nyrén O. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med. 1999 Mar 18;340(11):825–831. doi: 10.1056/NEJM199903183401101. [DOI] [PubMed] [Google Scholar]
- Levin T. R., Schmittdiel J. A., Kunz K., Henning J. M., Henke C. J., Colby C. J., Selby J. V. Costs of acid-related disorders to a health maintenance organization. Am J Med. 1997 Dec;103(6):520–528. doi: 10.1016/s0002-9343(97)00308-2. [DOI] [PubMed] [Google Scholar]
- Lind T., Havelund T., Lundell L., Glise H., Lauritsen K., Pedersen S. A., Anker-Hansen O., Stubberöd A., Eriksson G., Carlsson R. On demand therapy with omeprazole for the long-term management of patients with heartburn without oesophagitis--a placebo-controlled randomized trial. Aliment Pharmacol Ther. 1999 Jul;13(7):907–914. doi: 10.1046/j.1365-2036.1999.00564.x. [DOI] [PubMed] [Google Scholar]
- McDougall N. I., Johnston B. T., Kee F., Collins J. S., McFarland R. J., Love A. H. Natural history of reflux oesophagitis: a 10 year follow up of its effect on patient symptomatology and quality of life. Gut. 1996 Apr;38(4):481–486. doi: 10.1136/gut.38.4.481. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Mee A. S., Rowley J. L. Rapid symptom relief in reflux oesophagitis: a comparison of lansoprazole and omeprazole. Aliment Pharmacol Ther. 1996 Oct;10(5):757–763. doi: 10.1046/j.1365-2036.1996.56198000.x. [DOI] [PubMed] [Google Scholar]
- Schindlbeck N. E., Klauser A. G., Voderholzer W. A., Müller-Lissner S. A. Empiric therapy for gastroesophageal reflux disease. Arch Intern Med. 1995 Sep 11;155(16):1808–1812. [PubMed] [Google Scholar]
- de Boer W. A., Tytgat G. N. Review article: drug therapy for reflux oesophagitis. Aliment Pharmacol Ther. 1994 Apr;8(2):147–157. doi: 10.1111/j.1365-2036.1994.tb00272.x. [DOI] [PubMed] [Google Scholar]