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. 2003 Apr;79(930):201–203. doi: 10.1136/pmj.79.930.201

Impact of respiratory viral infections on cystic fibrosis

D Wat
PMCID: PMC1742676  PMID: 12743335

Abstract

The life expectancy for patients with cystic fibrosis has improved remarkably over the last 20 years. Progressive deterioration of pulmonary function continues despite the aggressive use of antimicrobials. The absence of fever, neutrophilia, and systemic symptoms suggest that during pulmonary exacerbations other non-bacterial factors may have played a part. Some have suggested respiratory viruses as main suspects. So far, few data have illustrated the relationship of respiratory viruses and cystic fibrosis. By gaining further knowledge of this relationship, one may change future clinical practice and boost the survival of these patients.

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Selected References

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  1. Abman S. H., Ogle J. W., Butler-Simon N., Rumack C. M., Accurso F. J. Role of respiratory syncytial virus in early hospitalizations for respiratory distress of young infants with cystic fibrosis. J Pediatr. 1988 Nov;113(5):826–830. doi: 10.1016/s0022-3476(88)80008-8. [DOI] [PubMed] [Google Scholar]
  2. Accurso F. J., Sokol R. J., Hammond K. B., Abman S. H. Early respiratory course in infants with cystic fibrosis: relevance to newborn screening. Pediatr Pulmonol Suppl. 1991;7:42–45. doi: 10.1002/ppul.1950110709. [DOI] [PubMed] [Google Scholar]
  3. Armstrong D. S., Grimwood K., Carlin J. B., Carzino R., Gutièrrez J. P., Hull J., Olinsky A., Phelan E. M., Robertson C. F., Phelan P. D. Lower airway inflammation in infants and young children with cystic fibrosis. Am J Respir Crit Care Med. 1997 Oct;156(4 Pt 1):1197–1204. doi: 10.1164/ajrccm.156.4.96-11058. [DOI] [PubMed] [Google Scholar]
  4. Armstrong D., Grimwood K., Carlin J. B., Carzino R., Hull J., Olinsky A., Phelan P. D. Severe viral respiratory infections in infants with cystic fibrosis. Pediatr Pulmonol. 1998 Dec;26(6):371–379. doi: 10.1002/(sici)1099-0496(199812)26:6<371::aid-ppul1>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  5. Barasch J., al-Awqati Q. Defective acidification of the biosynthetic pathway in cystic fibrosis. J Cell Sci Suppl. 1993;17:229–233. doi: 10.1242/jcs.1993.supplement_17.32. [DOI] [PubMed] [Google Scholar]
  6. Collinson J., Nicholson K. G., Cancio E., Ashman J., Ireland D. C., Hammersley V., Kent J., O'Callaghan C. Effects of upper respiratory tract infections in patients with cystic fibrosis. Thorax. 1996 Nov;51(11):1115–1122. doi: 10.1136/thx.51.11.1115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Elborn J. S., Shale D. J., Britton J. R. Cystic fibrosis: current survival and population estimates to the year 2000. Thorax. 1991 Dec;46(12):881–885. doi: 10.1136/thx.46.12.881. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Freymuth F., Vabret A., Brouard J., Toutain F., Verdon R., Petitjean J., Gouarin S., Duhamel J. F., Guillois B. Detection of viral, Chlamydia pneumoniae and Mycoplasma pneumoniae infections in exacerbations of asthma in children. J Clin Virol. 1999 Aug;13(3):131–139. doi: 10.1016/S1386-6532(99)00030-X. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Freymuth F., Vabret A., Galateau-Salle F., Ferey J., Eugene G., Petitjean J., Gennetay E., Brouard J., Jokik M., Duhamel J. F. Detection of respiratory syncytial virus, parainfluenzavirus 3, adenovirus and rhinovirus sequences in respiratory tract of infants by polymerase chain reaction and hybridization. Clin Diagn Virol. 1997 May;8(1):31–40. doi: 10.1016/s0928-0197(97)00060-3. [DOI] [PubMed] [Google Scholar]
  10. Gern J. E., Busse W. W. Association of rhinovirus infections with asthma. Clin Microbiol Rev. 1999 Jan;12(1):9–18. doi: 10.1128/cmr.12.1.9. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Ireland D. C., Kent J., Nicholson K. G. Improved detection of rhinoviruses in nasal and throat swabs by seminested RT-PCR. J Med Virol. 1993 Jun;40(2):96–101. doi: 10.1002/jmv.1890400204. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Johnston S. L., Pattemore P. K., Sanderson G., Smith S., Lampe F., Josephs L., Symington P., O'Toole S., Myint S. H., Tyrrell D. A. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995 May 13;310(6989):1225–1229. doi: 10.1136/bmj.310.6989.1225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Kim H. W., Canchola J. G., Brandt C. D., Pyles G., Chanock R. M., Jensen K., Parrott R. H. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol. 1969 Apr;89(4):422–434. doi: 10.1093/oxfordjournals.aje.a120955. [DOI] [PubMed] [Google Scholar]
  14. Mahadeva R., Webb K., Westerbeek R. C., Carroll N. R., Dodd M. E., Bilton D., Lomas D. A. Clinical outcome in relation to care in centres specialising in cystic fibrosis: cross sectional study. BMJ. 1998 Jun 13;316(7147):1771–1775. doi: 10.1136/bmj.316.7147.1771. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Niederman M. S., Merrill W. W., Ferranti R. D., Pagano K. M., Palmer L. B., Reynolds H. Y. Nutritional status and bacterial binding in the lower respiratory tract in patients with chronic tracheostomy. Ann Intern Med. 1984 Jun;100(6):795–800. doi: 10.7326/0003-4819-100-6-795. [DOI] [PubMed] [Google Scholar]
  16. Petersen N. T., Høiby N., Mordhorst C. H., Lind K., Flensborg E. W., Bruun B. Respiratory infections in cystic fibrosis patients caused by virus, chlamydia and mycoplasma--possible synergism with Pseudomonas aeruginosa. Acta Paediatr Scand. 1981 Sep;70(5):623–628. doi: 10.1111/j.1651-2227.1981.tb05757.x. [DOI] [PubMed] [Google Scholar]
  17. Ramsey B. W., Gore E. J., Smith A. L., Cooney M. K., Redding G. J., Foy H. The effect of respiratory viral infections on patients with cystic fibrosis. Am J Dis Child. 1989 Jun;143(6):662–668. doi: 10.1001/archpedi.1989.02150180040017. [DOI] [PubMed] [Google Scholar]
  18. Ramsey B. W., Pepe M. S., Quan J. M., Otto K. L., Montgomery A. B., Williams-Warren J., Vasiljev-K M., Borowitz D., Bowman C. M., Marshall B. C. Intermittent administration of inhaled tobramycin in patients with cystic fibrosis. Cystic Fibrosis Inhaled Tobramycin Study Group. N Engl J Med. 1999 Jan 7;340(1):23–30. doi: 10.1056/NEJM199901073400104. [DOI] [PubMed] [Google Scholar]
  19. Ratjen F. Changes in strategies for optimal antibacterial therapy in cystic fibrosis. Int J Antimicrob Agents. 2001 Feb;17(2):93–96. doi: 10.1016/s0924-8579(00)00333-2. [DOI] [PubMed] [Google Scholar]
  20. Riordan J. R., Rommens J. M., Kerem B., Alon N., Rozmahel R., Grzelczak Z., Zielenski J., Lok S., Plavsic N., Chou J. L. Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science. 1989 Sep 8;245(4922):1066–1073. doi: 10.1126/science.2475911. [DOI] [PubMed] [Google Scholar]
  21. Smith C. B., Golden C., Klauber M. R., Kanner R., Renzetti A. Interactions between viruses and bacteria in patients with chronic bronchitis. J Infect Dis. 1976 Dec;134(6):552–561. doi: 10.1093/infdis/134.6.552. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Smyth A. R., Smyth R. L., Tong C. Y., Hart C. A., Heaf D. P. Effect of respiratory virus infections including rhinovirus on clinical status in cystic fibrosis. Arch Dis Child. 1995 Aug;73(2):117–120. doi: 10.1136/adc.73.2.117. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Wang E. E., Prober C. G., Manson B., Corey M., Levison H. Association of respiratory viral infections with pulmonary deterioration in patients with cystic fibrosis. N Engl J Med. 1984 Dec 27;311(26):1653–1658. doi: 10.1056/NEJM198412273112602. [DOI] [PubMed] [Google Scholar]
  24. Wright P. F., Khaw K. T., Oxman M. N., Shwachman H. Evaluation of the safety of amantadine-HC1 and the role of respiratory viral infections in children with cystic fibrosis. J Infect Dis. 1976 Aug;134(2):144–149. doi: 10.1093/infdis/134.2.144. [DOI] [PubMed] [Google Scholar]
  25. Wright P. F., Khaw K. T., Oxman M. N., Shwachman H. Evaluation of the safety of amantadine-HC1 and the role of respiratory viral infections in children with cystic fibrosis. J Infect Dis. 1976 Aug;134(2):144–149. doi: 10.1093/infdis/134.2.144. [DOI] [PubMed] [Google Scholar]

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