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. 1996 Sep;64(9):3893–3896. doi: 10.1128/iai.64.9.3893-3896.1996

The hemagglutinin of Staphylococcus saprophyticus is a major adhesin for uroepithelial cells.

H G Meyer 1, U Wengler-Becker 1, S G Gatermann 1
PMCID: PMC174308  PMID: 8751944

Abstract

The 160-kDa hemagglutinin of Staphylococcus saprophyticus also serves as a fibronectin-binding protein, and the two activities may be present on different parts of the molecule. Bacteria expressing the 160-kDa hemagglutinin bound in large numbers to histological sections of human ureters, whereas nonhemagglutinating bacteria did not bind. Binding was decreased by an antiserum to the 160-kDa protein and by a preparation of sheep erythrocyte membranes. Fibronectin had no effect. We therefore conclude that binding of S. saprophyticus to uroepithelial cells is mediated by the hemagglutinating activity of the 160-kDa surface protein.

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Selected References

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