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. 2005 Mar;81(953):155–160. doi: 10.1136/pgmj.2004.024737

Placebo

H McQuay 1, R Moore 1
PMCID: PMC1743225  PMID: 15749790

Abstract

Placebo, used here to mean an inert treatment given as if it was a real treatment, means lots of different things to different people. The structure of the article is that it begins by talking about the technical use of placebos in clinical trials, and the extent of the placebo response, then about the mechanism—"How does the placebo work?"—and last about the ethics of placebo in the contexts of research and in everyday practice.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aronson J. Please, please me . BMJ. 1999 Mar 13;318(7185):716–716. doi: 10.1136/bmj.318.7185.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COBB L. A., THOMAS G. I., DILLARD D. H., MERENDINO K. A., BRUCE R. A. An evaluation of internal-mammary-artery ligation by a double-blind technic. N Engl J Med. 1959 May 28;260(22):1115–1118. doi: 10.1056/NEJM195905282602204. [DOI] [PubMed] [Google Scholar]
  3. Fedele L., Marchini M., Acaia B., Garagiola U., Tiengo M. Dynamics and significance of placebo response in primary dysmenorrhea. Pain. 1989 Jan;36(1):43–47. doi: 10.1016/0304-3959(89)90110-3. [DOI] [PubMed] [Google Scholar]
  4. Horng Sam, Miller Franklin G. Is placebo surgery unethical? N Engl J Med. 2002 Jul 11;347(2):137–139. doi: 10.1056/NEJMsb021025. [DOI] [PubMed] [Google Scholar]
  5. Kalso E., Moore R. A. Five easy pieces on evidence-based medicine (2). Eur J Pain. 2000;4(3):321–324. doi: 10.1053/eujp.2000.0191. [DOI] [PubMed] [Google Scholar]
  6. McQuay H., Carroll D., Moore A. Variation in the placebo effect in randomised controlled trials of analgesics: all is as blind as it seems. Pain. 1996 Feb;64(2):331–335. doi: 10.1016/0304-3959(95)00116-6. [DOI] [PubMed] [Google Scholar]
  7. Moore R. A., Gavaghan D., Tramèr M. R., Collins S. L., McQuay H. J. Size is everything--large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects. Pain. 1998 Dec;78(3):209–216. doi: 10.1016/S0304-3959(98)00140-7. [DOI] [PubMed] [Google Scholar]
  8. Moseley J. Bruce, O'Malley Kimberly, Petersen Nancy J., Menke Terri J., Brody Baruch A., Kuykendall David H., Hollingsworth John C., Ashton Carol M., Wray Nelda P. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med. 2002 Jul 11;347(2):81–88. doi: 10.1056/NEJMoa013259. [DOI] [PubMed] [Google Scholar]
  9. Petrovic Predrag, Kalso Eija, Petersson Karl Magnus, Ingvar Martin. Placebo and opioid analgesia-- imaging a shared neuronal network. Science. 2002 Feb 7;295(5560):1737–1740. doi: 10.1126/science.1067176. [DOI] [PubMed] [Google Scholar]
  10. Sinclair J. C., Bracken M. B. Clinically useful measures of effect in binary analyses of randomized trials. J Clin Epidemiol. 1994 Aug;47(8):881–889. doi: 10.1016/0895-4356(94)90191-0. [DOI] [PubMed] [Google Scholar]
  11. Tramèr M., Moore A., McQuay H. Omitting nitrous oxide in general anaesthesia: meta-analysis of intraoperative awareness and postoperative emesis in randomized controlled trials. Br J Anaesth. 1996 Feb;76(2):186–193. doi: 10.1093/bja/76.2.186. [DOI] [PubMed] [Google Scholar]
  12. Tramèr M., Moore A., McQuay H. Prevention of vomiting after paediatric strabismus surgery: a systematic review using the numbers-needed-to-treat method. Br J Anaesth. 1995 Nov;75(5):556–561. doi: 10.1093/bja/75.5.556. [DOI] [PubMed] [Google Scholar]
  13. Wager Tor D., Rilling James K., Smith Edward E., Sokolik Alex, Casey Kenneth L., Davidson Richard J., Kosslyn Stephen M., Rose Robert M., Cohen Jonathan D. Placebo-induced changes in FMRI in the anticipation and experience of pain. Science. 2004 Feb 20;303(5661):1162–1167. doi: 10.1126/science.1093065. [DOI] [PubMed] [Google Scholar]
  14. Walsh B. Timothy, Seidman Stuart N., Sysko Robyn, Gould Madelyn. Placebo response in studies of major depression: variable, substantial, and growing. JAMA. 2002 Apr 10;287(14):1840–1847. doi: 10.1001/jama.287.14.1840. [DOI] [PubMed] [Google Scholar]
  15. de Craen A. J., Tijssen J. G., de Gans J., Kleijnen J. Placebo effect in the acute treatment of migraine: subcutaneous placebos are better than oral placebos. J Neurol. 2000 Mar;247(3):183–188. doi: 10.1007/s004150050560. [DOI] [PubMed] [Google Scholar]

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