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. 2005 May;81(955):292–298. doi: 10.1136/pgmj.2004.026625

Congenital heart disease in pregnancy

C Head 1, S Thorne 1
PMCID: PMC1743261  PMID: 15879040

Abstract

Congenital heart disease is now more prevalent than acquired in pregnancy in the developed world. In pregnancy the fall in systemic vascular resistance and increase in blood volume and cardiac output can cause functional deterioration in certain conditions. A minimally symptomatic woman with good ventricular function, normal oxygen saturation, and no left heart obstruction should tolerate pregnancy well. Women with pulmonary hypertension or dilated aortic root (pre-replacement) should be counselled against pregnancy and given appropriate contraceptive advice. The optimum management of a pregnant woman with a metallic prosthetic valve remains to be determined.

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Selected References

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  1. Avila W. S., Grinberg M., Snitcowsky R., Faccioli R., Da Luz P. L., Bellotti G., Pileggi F. Maternal and fetal outcome in pregnant women with Eisenmenger's syndrome. Eur Heart J. 1995 Apr;16(4):460–464. doi: 10.1093/oxfordjournals.eurheartj.a060936. [DOI] [PubMed] [Google Scholar]
  2. Avila Walkiria S., Rossi Eduardo G., Grinberg Max, Ramires José A. F. Influence of pregnancy after bioprosthetic valve replacement in young women: a prospective five-year study. J Heart Valve Dis. 2002 Nov;11(6):864–869. [PubMed] [Google Scholar]
  3. Beauchesne L. M., Connolly H. M., Ammash N. M., Warnes C. A. Coarctation of the aorta: outcome of pregnancy. J Am Coll Cardiol. 2001 Nov 15;38(6):1728–1733. doi: 10.1016/s0735-1097(01)01617-5. [DOI] [PubMed] [Google Scholar]
  4. Burn J., Brennan P., Little J., Holloway S., Coffey R., Somerville J., Dennis N. R., Allan L., Arnold R., Deanfield J. E. Recurrence risks in offspring of adults with major heart defects: results from first cohort of British collaborative study. Lancet. 1998 Jan 31;351(9099):311–316. doi: 10.1016/s0140-6736(97)06486-6. [DOI] [PubMed] [Google Scholar]
  5. Canobbio M. M., Mair D. D., van der Velde M., Koos B. J. Pregnancy outcomes after the Fontan repair. J Am Coll Cardiol. 1996 Sep;28(3):763–767. doi: 10.1016/0735-1097(96)00234-3. [DOI] [PubMed] [Google Scholar]
  6. Chan W. S., Anand S., Ginsberg J. S. Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature. Arch Intern Med. 2000 Jan 24;160(2):191–196. doi: 10.1001/archinte.160.2.191. [DOI] [PubMed] [Google Scholar]
  7. Clarkson P. M., Wilson N. J., Neutze J. M., North R. A., Calder A. L., Barratt-Boyes B. G. Outcome of pregnancy after the Mustard operation for transposition of the great arteries with intact ventricular septum. J Am Coll Cardiol. 1994 Jul;24(1):190–193. doi: 10.1016/0735-1097(94)90562-2. [DOI] [PubMed] [Google Scholar]
  8. Cutforth R., MacDonald C. B. Heart sounds and murmurs in pregnancy. Am Heart J. 1966 Jun;71(6):741–747. doi: 10.1016/0002-8703(66)90594-1. [DOI] [PubMed] [Google Scholar]
  9. Dajani A. S., Taubert K. A., Wilson W., Bolger A. F., Bayer A., Ferrieri P., Gewitz M. H., Shulman S. T., Nouri S., Newburger J. W. Prevention of bacterial endocarditis. Recommendations by the American Heart Association. Circulation. 1997 Jul 1;96(1):358–366. doi: 10.1161/01.cir.96.1.358. [DOI] [PubMed] [Google Scholar]
  10. Genoni M., Jenni R., Hoerstrup S. P., Vogt P., Turina M. Pregnancy after atrial repair for transposition of the great arteries. Heart. 1999 Mar;81(3):276–277. doi: 10.1136/hrt.81.3.276. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gill Harinder K., Splitt Miranda, Sharland Gurleen K., Simpson John M. Patterns of recurrence of congenital heart disease: an analysis of 6,640 consecutive pregnancies evaluated by detailed fetal echocardiography. J Am Coll Cardiol. 2003 Sep 3;42(5):923–929. doi: 10.1016/s0735-1097(03)00853-2. [DOI] [PubMed] [Google Scholar]
  12. Immer Franz F., Bansi Anne G., Immer-Bansi Alexsandra S., McDougall Jane, Zehr Kenton J., Schaff Hartzell V., Carrel Thierry P. Aortic dissection in pregnancy: analysis of risk factors and outcome. Ann Thorac Surg. 2003 Jul;76(1):309–314. doi: 10.1016/s0003-4975(03)00169-3. [DOI] [PubMed] [Google Scholar]
  13. Lalchandani S., Wingfield M. Pregnancy in women with Marfan's Syndrome. Eur J Obstet Gynecol Reprod Biol. 2003 Oct 10;110(2):125–130. doi: 10.1016/s0301-2115(03)00151-9. [DOI] [PubMed] [Google Scholar]
  14. Perloff J. K. Congenital heart disease in adults. A new cardiovascular subspecialty. Circulation. 1991 Nov;84(5):1881–1890. doi: 10.1161/01.cir.84.5.1881. [DOI] [PubMed] [Google Scholar]
  15. Pitkin R. M., Perloff J. K., Koos B. J., Beall M. H. Pregnancy and congenital heart disease. Ann Intern Med. 1990 Mar 15;112(6):445–454. doi: 10.7326/0003-4819-76-3-112-6-445. [DOI] [PubMed] [Google Scholar]
  16. Presbitero P., Somerville J., Stone S., Aruta E., Spiegelhalter D., Rabajoli F. Pregnancy in cyanotic congenital heart disease. Outcome of mother and fetus. Circulation. 1994 Jun;89(6):2673–2676. doi: 10.1161/01.cir.89.6.2673. [DOI] [PubMed] [Google Scholar]
  17. Silversides Candice K., Colman Jack M., Sermer Mathew, Farine Dan, Siu Samuel C. Early and intermediate-term outcomes of pregnancy with congenital aortic stenosis. Am J Cardiol. 2003 Jun 1;91(11):1386–1389. doi: 10.1016/s0002-9149(03)00340-0. [DOI] [PubMed] [Google Scholar]
  18. Siu S. C., Sermer M., Colman J. M., Alvarez A. N., Mercier L. A., Morton B. C., Kells C. M., Bergin M. L., Kiess M. C., Marcotte F. Prospective multicenter study of pregnancy outcomes in women with heart disease. Circulation. 2001 Jul 31;104(5):515–521. doi: 10.1161/hc3001.093437. [DOI] [PubMed] [Google Scholar]
  19. Vitale N., De Feo M., De Santo L. S., Pollice A., Tedesco N., Cotrufo M. Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves. J Am Coll Cardiol. 1999 May;33(6):1637–1641. doi: 10.1016/s0735-1097(99)00044-3. [DOI] [PubMed] [Google Scholar]
  20. Weiss B. M., Hess O. M. Pulmonary vascular disease and pregnancy: current controversies, management strategies, and perspectives. Eur Heart J. 2000 Jan;21(2):104–115. doi: 10.1053/euhj.1999.1701. [DOI] [PubMed] [Google Scholar]
  21. Weiss B. M., von Segesser L. K., Alon E., Seifert B., Turina M. I. Outcome of cardiovascular surgery and pregnancy: a systematic review of the period 1984-1996. Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1643–1653. doi: 10.1016/s0002-9378(98)70039-0. [DOI] [PubMed] [Google Scholar]
  22. Wren C., O'Sullivan J. J. Survival with congenital heart disease and need for follow up in adult life. Heart. 2001 Apr;85(4):438–443. doi: 10.1136/heart.85.4.438. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Yentis S. M., Steer P. J., Plaat F. Eisenmenger's syndrome in pregnancy: maternal and fetal mortality in the 1990s. Br J Obstet Gynaecol. 1998 Aug;105(8):921–922. doi: 10.1111/j.1471-0528.1998.tb10240.x. [DOI] [PubMed] [Google Scholar]
  24. Yentis Steve, Gatzoulis Michael A., Steer Philip. Pregnancy and coarctation of the aorta. J R Soc Med. 2003 Sep;96(9):471–471. doi: 10.1258/jrsm.96.9.471. [DOI] [PMC free article] [PubMed] [Google Scholar]

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