Abstract
Dupuytren's disease (DD) is a common progressive fibrotic condition affecting the palmar and digital fascia. Although its management is undertaken by hand surgeons, it is commonly seen by other doctors as an incidental finding. In many cases it is believed to be associated with other medical conditions, although the evidence for such associations is not always clear. This review considers the evidence behind these associations and discusses the aetiology of DD. By doing so, it is hoped that this review will permit a better understanding of the relevance of DD as a clinical sign.
Full Text
The Full Text of this article is available as a PDF (92.4 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arafa M., Noble J., Royle S. G., Trail I. A., Allen J. Dupuytren's and epilepsy revisited. J Hand Surg Br. 1992 Apr;17(2):221–224. doi: 10.1016/0266-7681(92)90095-j. [DOI] [PubMed] [Google Scholar]
- Arafa M., Steingold R. F., Noble J. The incidence of Dupuytren's disease in patients with rheumatoid arthritis. J Hand Surg Br. 1984 Jun;9(2):165–166. [PubMed] [Google Scholar]
- Arkkila P. E., Kantola I. M., Viikari J. S. Dupuytren's disease: association with chronic diabetic complications. J Rheumatol. 1997 Jan;24(1):153–159. [PubMed] [Google Scholar]
- Arkkila P. E., Kantola I. M., Viikari J. S., Rönnemaa T., Vähätalo M. A. Dupuytren's disease in type 1 diabetic patients: a five-year prospective study. Clin Exp Rheumatol. 1996 Jan-Feb;14(1):59–65. [PubMed] [Google Scholar]
- Attali P., Ink O., Pelletier G., Vernier C., Jean F., Moulton L., Etienne J. P. Dupuytren's contracture, alcohol consumption, and chronic liver disease. Arch Intern Med. 1987 Jun;147(6):1065–1067. [PubMed] [Google Scholar]
- Bower M., Nelson M., Gazzard B. G. Dupuytren's contractures in patients infected with HIV. BMJ. 1990 Jan 20;300(6718):164–165. doi: 10.1136/bmj.300.6718.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carrieri M. P., Serraino D., Palmiotto F., Nucci G., Sasso F. A case-control study on risk factors for Peyronie's disease. J Clin Epidemiol. 1998 Jun;51(6):511–515. doi: 10.1016/s0895-4356(98)00015-8. [DOI] [PubMed] [Google Scholar]
- Carson J., Clarke C. Dupuytren's contracture in pensioners at the Royal Hospital Chelsea. J R Coll Physicians Lond. 1993 Jan;27(1):25–27. [PMC free article] [PubMed] [Google Scholar]
- Critchley E. M., Vakil S. D., Hayward H. W., Owen V. M. Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants. J Neurol Neurosurg Psychiatry. 1976 May;39(5):498–503. doi: 10.1136/jnnp.39.5.498. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DAVIDSON C. S., SUMMERSKILL W. H., WOLFE S. J. Thickening and contraction of the palmar fascia (Dupuytren's contracture) associated with alcoholism and hepatic cirrhosis. N Engl J Med. 1956 Sep 20;255(12):559–563. doi: 10.1056/NEJM195609202551204. [DOI] [PubMed] [Google Scholar]
- Elliot D. The early history of contracture of the palmar fascia. Part 1: The origin of the disease: the curse of the MacCrimmons: the hand of benediction: Cline's contracture. J Hand Surg Br. 1988 Aug;13(3):246–253. doi: 10.1016/0266-7681_88_90078-2. [DOI] [PubMed] [Google Scholar]
- GORDON S. Dupuytren's contracture: the significance of various factors in its etiology. Ann Surg. 1954 Nov;140(5):683–686. doi: 10.1097/00000658-195411000-00007. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gudmundsson K. G., Arngrímsson R., Sigfússon N., Björnsson A., Jónsson T. Epidemiology of Dupuytren's disease: clinical, serological, and social assessment. The Reykjavik Study. J Clin Epidemiol. 2000 Mar 1;53(3):291–296. doi: 10.1016/s0895-4356(99)00145-6. [DOI] [PubMed] [Google Scholar]
- HERZOG E. G. The aetiology of Dupuytren's contracture. Lancet. 1951 Jun 16;1(6668):1305–1306. doi: 10.1016/s0140-6736(51)91775-8. [DOI] [PubMed] [Google Scholar]
- Heathcote J. G., Cohen H., Noble J. Dupuytren's disease and diabetes mellitus. Lancet. 1981 Jun 27;1(8235):1420–1420. doi: 10.1016/s0140-6736(81)92594-0. [DOI] [PubMed] [Google Scholar]
- Hueston J. T. Dupuytren's contracture and specific injury. Med J Aust. 1968 Jun 22;1(25):1084–1085. doi: 10.5694/j.1326-5377.1968.tb29329.x. [DOI] [PubMed] [Google Scholar]
- LING R. S. THE GENETIC FACTOR IN DUPUYTREN'S DISEASE. J Bone Joint Surg Br. 1963 Nov;45(4):709–718. [PubMed] [Google Scholar]
- Larkin J. G., Frier B. M. Limited joint mobility and Dupuytren's contracture in diabetic, hypertensive, and normal populations. Br Med J (Clin Res Ed) 1986 Jun 7;292(6534):1494–1494. doi: 10.1136/bmj.292.6534.1494. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lawson P. M., Maneschi F., Kohner E. M. The relationship of hand abnormalities to diabetes and diabetic retinopathy. Diabetes Care. 1983 Mar-Apr;6(2):140–143. doi: 10.2337/diacare.6.2.140. [DOI] [PubMed] [Google Scholar]
- Lennox I. A., Murali S. R., Porter R. A study of the repeatability of the diagnosis of Dupuytren's contracture and its prevalence in the grampian region. J Hand Surg Br. 1993 Apr;18(2):258–261. doi: 10.1016/0266-7681(93)90124-x. [DOI] [PubMed] [Google Scholar]
- MOORHEAD J. J. Dupuytren's contracture; review of the disputed etiology; 1831-1956. N Y State J Med. 1956 Dec 1;56(23):3686–3703. [PubMed] [Google Scholar]
- Mikkelsen O. A., Høyeraal H. M., Sandvik L. Increased mortality in Dupuytren's disease. J Hand Surg Br. 1999 Oct;24(5):515–518. doi: 10.1054/jhsb.1999.0229. [DOI] [PubMed] [Google Scholar]
- Murrell G. A. An insight into Dupuytren's contracture. Ann R Coll Surg Engl. 1992 May;74(3):156–161. [PMC free article] [PubMed] [Google Scholar]
- Murrell G. A., Francis M. J., Howlett C. R. Dupuytren's contracture. Fine structure in relation to aetiology. J Bone Joint Surg Br. 1989 May;71(3):367–373. doi: 10.1302/0301-620X.71B3.2722922. [DOI] [PubMed] [Google Scholar]
- Murrell G. A., Hueston J. T. Aetiology of Dupuytren's contracture. Aust N Z J Surg. 1990 Apr;60(4):247–252. doi: 10.1111/j.1445-2197.1990.tb07362.x. [DOI] [PubMed] [Google Scholar]
- Nazari B. Dupuytren's contracture associated with liver disease. J Mt Sinai Hosp N Y. 1966 Jan-Feb;33(1):69–72. [PubMed] [Google Scholar]
- Noble J., Heathcote J. G., Cohen H. Diabetes mellitus in the aetiology of Dupuytren's disease. J Bone Joint Surg Br. 1984 May;66(3):322–325. doi: 10.1302/0301-620X.66B3.6725338. [DOI] [PubMed] [Google Scholar]
- Pojer J., Radivojevic M., Williams T. F. Dupuytren's disease. Its association with abnormal liver function in alcoholism and epilepsy. Arch Intern Med. 1972 Apr;129(4):561–566. doi: 10.1001/archinte.129.4.561. [DOI] [PubMed] [Google Scholar]
- SUMMERSKILL W. H., DAVIDSON C. S., DIBLE J. H., MALLORY G. K., SHERLOCK S., TURNER M. D., WOLFE S. J. Cirrhosis of the liver: a study of alcoholic and nonalcoholic patients in Boston and London. N Engl J Med. 1960 Jan 7;262:1–9. doi: 10.1056/NEJM196001072620101. [DOI] [PubMed] [Google Scholar]
- Saboeiro A. P., Porkorny J. J., Shehadi S. I., Virgo K. S., Johnson F. E. Racial distribution of Dupuytren's disease in Department of Veterans Affairs patients. Plast Reconstr Surg. 2000 Jul;106(1):71–75. doi: 10.1097/00006534-200007000-00013. [DOI] [PubMed] [Google Scholar]
- Su C. K., Patek A. J., Jr Dupuytren's contracture. Its association with alcoholism and cirrhosis. Arch Intern Med. 1970 Aug;126(2):278–281. doi: 10.1001/archinte.126.2.278. [DOI] [PubMed] [Google Scholar]
- Verheyden C. N. The history of Dupuytren's contracture. Clin Plast Surg. 1983 Oct;10(4):619–625. [PubMed] [Google Scholar]
- YOST J., WINTERS T., FETT H. C., Sr Dupuytren's contracture; a statistical study. Am J Surg. 1955 Oct;90(4):568–571. doi: 10.1016/0002-9610(55)90537-7. [DOI] [PubMed] [Google Scholar]