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. 2005 Aug;81(958):526–529. doi: 10.1136/pgmj.2004.030825

Polymorphisms of CD14 gene and TLR4 gene are not associated with ulcerative colitis in Chinese patients

Q Guo 1, B Xia 1, Y Jiang 1, S Morre 1, L Cheng 1, J Li 1, J Crusius 1, A Pena 1
PMCID: PMC1743318  PMID: 16085746

Abstract

Background and aims: Toll-like receptor 4 and CD14 are the components of the lipopolysaccharide receptor complex. The aim of this study was to investigate the associations between polymorphisms TLR4 Asp299Gly and CD14 C-260T and Chinese patients with ulcerative colitis (UC).

Methods: Using a polymerase chain reaction based restriction fragment length polymorphism, the study genotyped polymorphisms TLR4 Asp299Gly and CD14 C-260T in 114 patients with UC and 160 healthy controls in the Chinese Han population. Moreover a comparison was made with 170 healthy Dutch white subjects.

Results: No TLR4 Asp299Gly mutation was detected in any patients or healthy controls in the Chinese Han population, which was similar to Japanese subjects, but the mutation occurred in 10% of the Dutch white subjects. There were no significant differences of CD14 genotypes between healthy controls and the patients with UC.

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Selected References

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