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Postgraduate Medical Journal logoLink to Postgraduate Medical Journal
. 2005 Sep;81(959):e12. doi: 10.1136/pgmj.2004.029611

Gastrointestinal involvement in POEMS syndrome: a novel clinical manifestation

S Dogan, Y Beyazit, A Shorbagi, S Koklu, S Ustunel, N Guler, A Uner
PMCID: PMC1743357  PMID: 16143676

Abstract

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes) is characterised by a rare multisystem disorder of unknown pathogenesis. Although its pathophysiology is not well understood, overexpression of proinflammatory cytokines has been implicated. Gastrointestinal system disorders have not been reported among the components of the syndrome. A case is reported of POEMS syndrome with gastrointestinal involvement shown by gastrointestinal endoscopy.

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