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. 2005 Nov;81(961):715–718. doi: 10.1136/pgmj.2004.031203

Epidemiology, clinical characteristics, and management of adults referred to a teaching hospital first seizure clinic

D Breen 1, M Dunn 1, R Davenport 1, A Gray 1
PMCID: PMC1743386  PMID: 16272236

Abstract

Background: There are scarce data describing the epidemiology, clinical characteristics, and management of adults who suffer a suspected first seizure.

Aim: To describe the epidemiology, clinical characteristics, and management of adults with a suspected first seizure who are referred to a teaching hospital first seizure clinic over a one year period.

Design: Prospective descriptive study.

Methods: Data were collected on consecutive adults referred to the Royal Infirmary of Edinburgh between 4 February 2003 and 10 February 2004.

Results: 232 patients were referred to the first seizure clinic. Median age was 32 years; 53% of patients were male. Lower socioeconomic groups were more likely to present with a suspected first seizure. Nineteen per cent of patients were admitted to hospital after their suspected seizure episode. Appropriate driving advice was reported in 64% of cases. Seventy two per cent of patients were offered a first seizure clinic appointment within six weeks of referral. Nine per cent of patients had a subsequent seizure while awaiting review. Fifty two per cent of patients were confirmed as having a first seizure at the clinic, of which 56% were provoked by alcohol, recreational drugs, or sleep deprivation. Electroencephalography and computed tomography of the brain were the most common investigations ordered at the first seizure clinic (22% and 22% of patients respectively).

Conclusion: Adults who suffer a suspected first seizure, and who make a full neurological recovery, can be safely managed as an outpatient. Around half of these patients will have a specialist diagnosis of first seizure and alcohol will be a common precipitating factor.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Berg A. T., Shinnar S. The risk of seizure recurrence following a first unprovoked seizure: a quantitative review. Neurology. 1991 Jul;41(7):965–972. doi: 10.1212/wnl.41.7.965. [DOI] [PubMed] [Google Scholar]
  2. Capes S. E., Hunt D., Malmberg K., Pathak P., Gerstein H. C. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001 Oct;32(10):2426–2432. doi: 10.1161/hs1001.096194. [DOI] [PubMed] [Google Scholar]
  3. Dunn M. J. G., Breen D. P., Davenport R. J., Gray A. J. Early management of adults with an uncomplicated first generalised seizure. Emerg Med J. 2005 Apr;22(4):237–242. doi: 10.1136/emj.2004.015651. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Edmondstone W. M. How do we manage the first seizure in adults? J R Coll Physicians Lond. 1995 Jul-Aug;29(4):289–294. [PMC free article] [PubMed] [Google Scholar]
  5. Forsgren L., Bucht G., Eriksson S., Bergmark L. Incidence and clinical characterization of unprovoked seizures in adults: a prospective population-based study. Epilepsia. 1996 Mar;37(3):224–229. doi: 10.1111/j.1528-1157.1996.tb00017.x. [DOI] [PubMed] [Google Scholar]
  6. Hauser W. A., Annegers J. F., Kurland L. T. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia. 1993 May-Jun;34(3):453–468. doi: 10.1111/j.1528-1157.1993.tb02586.x. [DOI] [PubMed] [Google Scholar]
  7. Henneman P. L., DeRoos F., Lewis R. J. Determining the need for admission in patients with new-onset seizures. Ann Emerg Med. 1994 Dec;24(6):1108–1114. doi: 10.1016/s0196-0644(94)70240-3. [DOI] [PubMed] [Google Scholar]
  8. King M. A., Newton M. R., Jackson G. D., Fitt G. J., Mitchell L. A., Silvapulle M. J., Berkovic S. F. Epileptology of the first-seizure presentation: a clinical, electroencephalographic, and magnetic resonance imaging study of 300 consecutive patients. Lancet. 1998 Sep 26;352(9133):1007–1011. doi: 10.1016/S0140-6736(98)03543-0. [DOI] [PubMed] [Google Scholar]
  9. Morgan J., Cullen W., Bury G., Turner M. J. Profile of attendance at a maternity hospital emergency room. Ir J Med Sci. 2000 Apr-Jun;169(2):122–124. doi: 10.1007/BF03166914. [DOI] [PubMed] [Google Scholar]
  10. Morrison A. D., McAlpine C. H. The management of first seizures in adults in a district general hospital. Scott Med J. 1997 Jun;42(3):73–75. doi: 10.1177/003693309704200303. [DOI] [PubMed] [Google Scholar]
  11. Powers R. D. Serum chemistry abnormalities in adult patients with seizures. Ann Emerg Med. 1985 May;14(5):416–420. doi: 10.1016/s0196-0644(85)80284-5. [DOI] [PubMed] [Google Scholar]
  12. Round A. Emergency medical admissions to hospital--the influence of supply factors. Public Health. 1997 Jul;111(4):221–224. doi: 10.1038/sj.ph.1900369. [DOI] [PubMed] [Google Scholar]
  13. Ryan J., Nash S., Lyndon J. Epilepsy in the accident and emergency department--developing a code of safe practice for adult patients. South East and South West Thames Accident and Emergency Specialty Sub-committees. J Accid Emerg Med. 1998 Jul;15(4):237–243. doi: 10.1136/emj.15.4.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Turnbull T. L., Vanden Hoek T. L., Howes D. S., Eisner R. F. Utility of laboratory studies in the emergency department patient with a new-onset seizure. Ann Emerg Med. 1990 Apr;19(4):373–377. doi: 10.1016/s0196-0644(05)82337-6. [DOI] [PubMed] [Google Scholar]

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