Abstract
Background: There are scarce data describing the epidemiology, clinical characteristics, and management of adults who suffer a suspected first seizure.
Aim: To describe the epidemiology, clinical characteristics, and management of adults with a suspected first seizure who are referred to a teaching hospital first seizure clinic over a one year period.
Design: Prospective descriptive study.
Methods: Data were collected on consecutive adults referred to the Royal Infirmary of Edinburgh between 4 February 2003 and 10 February 2004.
Results: 232 patients were referred to the first seizure clinic. Median age was 32 years; 53% of patients were male. Lower socioeconomic groups were more likely to present with a suspected first seizure. Nineteen per cent of patients were admitted to hospital after their suspected seizure episode. Appropriate driving advice was reported in 64% of cases. Seventy two per cent of patients were offered a first seizure clinic appointment within six weeks of referral. Nine per cent of patients had a subsequent seizure while awaiting review. Fifty two per cent of patients were confirmed as having a first seizure at the clinic, of which 56% were provoked by alcohol, recreational drugs, or sleep deprivation. Electroencephalography and computed tomography of the brain were the most common investigations ordered at the first seizure clinic (22% and 22% of patients respectively).
Conclusion: Adults who suffer a suspected first seizure, and who make a full neurological recovery, can be safely managed as an outpatient. Around half of these patients will have a specialist diagnosis of first seizure and alcohol will be a common precipitating factor.
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Selected References
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- Berg A. T., Shinnar S. The risk of seizure recurrence following a first unprovoked seizure: a quantitative review. Neurology. 1991 Jul;41(7):965–972. doi: 10.1212/wnl.41.7.965. [DOI] [PubMed] [Google Scholar]
- Capes S. E., Hunt D., Malmberg K., Pathak P., Gerstein H. C. Stress hyperglycemia and prognosis of stroke in nondiabetic and diabetic patients: a systematic overview. Stroke. 2001 Oct;32(10):2426–2432. doi: 10.1161/hs1001.096194. [DOI] [PubMed] [Google Scholar]
- Dunn M. J. G., Breen D. P., Davenport R. J., Gray A. J. Early management of adults with an uncomplicated first generalised seizure. Emerg Med J. 2005 Apr;22(4):237–242. doi: 10.1136/emj.2004.015651. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Edmondstone W. M. How do we manage the first seizure in adults? J R Coll Physicians Lond. 1995 Jul-Aug;29(4):289–294. [PMC free article] [PubMed] [Google Scholar]
- Forsgren L., Bucht G., Eriksson S., Bergmark L. Incidence and clinical characterization of unprovoked seizures in adults: a prospective population-based study. Epilepsia. 1996 Mar;37(3):224–229. doi: 10.1111/j.1528-1157.1996.tb00017.x. [DOI] [PubMed] [Google Scholar]
- Hauser W. A., Annegers J. F., Kurland L. T. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935-1984. Epilepsia. 1993 May-Jun;34(3):453–468. doi: 10.1111/j.1528-1157.1993.tb02586.x. [DOI] [PubMed] [Google Scholar]
- Henneman P. L., DeRoos F., Lewis R. J. Determining the need for admission in patients with new-onset seizures. Ann Emerg Med. 1994 Dec;24(6):1108–1114. doi: 10.1016/s0196-0644(94)70240-3. [DOI] [PubMed] [Google Scholar]
- King M. A., Newton M. R., Jackson G. D., Fitt G. J., Mitchell L. A., Silvapulle M. J., Berkovic S. F. Epileptology of the first-seizure presentation: a clinical, electroencephalographic, and magnetic resonance imaging study of 300 consecutive patients. Lancet. 1998 Sep 26;352(9133):1007–1011. doi: 10.1016/S0140-6736(98)03543-0. [DOI] [PubMed] [Google Scholar]
- Morgan J., Cullen W., Bury G., Turner M. J. Profile of attendance at a maternity hospital emergency room. Ir J Med Sci. 2000 Apr-Jun;169(2):122–124. doi: 10.1007/BF03166914. [DOI] [PubMed] [Google Scholar]
- Morrison A. D., McAlpine C. H. The management of first seizures in adults in a district general hospital. Scott Med J. 1997 Jun;42(3):73–75. doi: 10.1177/003693309704200303. [DOI] [PubMed] [Google Scholar]
- Powers R. D. Serum chemistry abnormalities in adult patients with seizures. Ann Emerg Med. 1985 May;14(5):416–420. doi: 10.1016/s0196-0644(85)80284-5. [DOI] [PubMed] [Google Scholar]
- Round A. Emergency medical admissions to hospital--the influence of supply factors. Public Health. 1997 Jul;111(4):221–224. doi: 10.1038/sj.ph.1900369. [DOI] [PubMed] [Google Scholar]
- Ryan J., Nash S., Lyndon J. Epilepsy in the accident and emergency department--developing a code of safe practice for adult patients. South East and South West Thames Accident and Emergency Specialty Sub-committees. J Accid Emerg Med. 1998 Jul;15(4):237–243. doi: 10.1136/emj.15.4.237. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Turnbull T. L., Vanden Hoek T. L., Howes D. S., Eisner R. F. Utility of laboratory studies in the emergency department patient with a new-onset seizure. Ann Emerg Med. 1990 Apr;19(4):373–377. doi: 10.1016/s0196-0644(05)82337-6. [DOI] [PubMed] [Google Scholar]
