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. 1996 Oct;64(10):4385–4389. doi: 10.1128/iai.64.10.4385-4389.1996

Induction of Th1 cytokine responses by mycobacterial antigens in leprosy.

H M Dockrell 1, S K Young 1, K Britton 1, P J Brennan 1, B Rivoire 1, M F Waters 1, S B Lucas 1, F Shahid 1, M Dojki 1, T J Chiang 1, Q Ehsan 1, K P McAdam 1, R Hussain 1
PMCID: PMC174386  PMID: 8926118

Abstract

Twelve mycobacterial antigens were compared for induction of gamma interferon (IFN-gamma) secretion by human blood mononuclear cells of patients with leprosy. Fractionated Mycobacterium leprae antigens containing cell wall proteins or cytosolic and membrane proteins induced good IFN-gamma responses in tuberculoid leprosy patients. Lipoarabinomannan from M. tuberculosis Erdman and M. leprae mycolylarabinogalactan peptidoglycan were the poorest IFN-gamma inducers.

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Selected References

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