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. 1996 Nov;64(11):4574–4579. doi: 10.1128/iai.64.11.4574-4579.1996

Role of nonspecific cross-reacting antigen, a CD66 cluster antigen, in activation of human granulocytes.

M L Klein 1, S A McGhee 1, J Baranian 1, L Stevens 1, S A Hefta 1
PMCID: PMC174415  PMID: 8890209

Abstract

Nonspecific cross-reacting antigen (NCA) is the name of a family of highly glycosylated bacterial-binding receptors found on human granulocytes and other tissues. These glycoproteins are members of the immunoglobulin supergene family and are related structurally to carcinoembryonic antigen. In this study, we demonstrate that ligation of granulocyte NCA results in the activation of the cells, as measured by degranulation and the flux of intracellular calcium. These studies further the proposition that NCA has a function in the immune response of granulocytes against bacterial infections.

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Selected References

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